Results 61 to 70 of about 1,344 (153)

Bibliometric Analysis of Global Research on Clavulanic Acid

Antibiotics, 2018
Clavulanic acid (CA), a potent inhibitor of the β-lactam, ase enzyme, is frequently co-formulated with a broad spectrum of antibiotics to treat infections caused by β-lactamase-producing pathogens.
Howard Ramirez-Malule
doaj   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

The Roles of Carbon‐Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Systematic media optimization in Amycolatopsis orientalis identified maltodextrin, soy‐based nitrogen sources, and phosphate regulation as key drivers of vancomycin yield. Knockout and feeding trials demonstrated essential nutrient roles, offering a cost‐effective, scalable strategy for enhanced antibiotic production.
Vineeth Mani, Sivakamavalli Jeyachandran, Mohammed Aman   +2 more
wiley   +1 more source

In silico approach for potential antimicrobial agents through antiviral, molecular docking, molecular dynamics, pharmacokinetic and bioactivity predictions of galactopyranoside derivatives

Arab Journal of Basic and Applied Sciences, 2022
Carbohydrates derivatives played an important and vital role in a large part to design new potential drug against various pathogens, in medicinal chemistry.
Sarkar M. A. Kawsar, Mohammed A. Hosen, Youness El Bakri, Sajjad Ahmad, Sopi T. Affi, Souraya Goumri-Said   +5 more
doaj   +1 more source

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. [PDF]

PLoS ONE, 2012
Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance.
Pep Charusanti, Nicole L Fong, Harish Nagarajan, Alban R Pereira, Howard J Li, Elisa A Abate, Yongxuan Su, William H Gerwick, Bernhard O Palsson   +8 more
doaj   +1 more source

Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus [PDF]

Antimicrobial Agents and Chemotherapy, 1978
Cephalosporin production by Streptomyces clavuligerus is regulated by some type of carbon catabolite control. Increasing concentrations of preferred carbon sources, such as glycerol and maltose, decreased production of the antibiotics.
Y, Aharonowitz, A L, Demain
openaire   +2 more sources

Production of the Sesquiterpene Bisabolene From One‐ and Two‐Carbon Compounds in Engineered Methanosarcina acetivorans

Microbial Biotechnology, Volume 18, Issue 2, February 2025.
Despite the versatile metabolic capacities of methanogenic archaea, they are currently only employed in biotechnology for their methane generating ability. We engineered Methanosarcina acetivorans to produce the sesquiterpene bisabolene from Abies grandis from methanol or from carbon monoxide.
Andrea Mentrup, Luca V. Scheitz, Theo Wallenfang, Michael Rother   +3 more
wiley   +1 more source

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

Synthetic and Systems Biotechnology, 2021
Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of ...
Xiaofan Niu, Jian Zhang, Xianli Xue, Depei Wang, Lin Wang, Qiang Gao   +5 more
doaj   +1 more source

Simultaneous state‐estimator tuning and parameter estimation for systems with nonstationary disturbances, multi‐rate data, and measurement delays

The Canadian Journal of Chemical Engineering, Volume 103, Issue 1, Page 323-338, January 2025.
Abstract Model‐based monitoring and control of chemical and biochemical processes rely on state estimators such as extended Kalman filters (EKFs) to ensure accurate online model predictions. Accurate predictions depend on appropriate model parameters and suitable state‐estimator tuning factors.
Qiujun A. Liu, Kimberley B. McAuley
wiley   +1 more source