Results 71 to 80 of about 38,235 (184)

In silico approach for potential antimicrobial agents through antiviral, molecular docking, molecular dynamics, pharmacokinetic and bioactivity predictions of galactopyranoside derivatives

Arab Journal of Basic and Applied Sciences, 2022
Carbohydrates derivatives played an important and vital role in a large part to design new potential drug against various pathogens, in medicinal chemistry.
Sarkar M. A. Kawsar, Mohammed A. Hosen, Youness El Bakri, Sajjad Ahmad, Sopi T. Affi, Souraya Goumri-Said   +5 more
doaj   +1 more source

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. [PDF]

PLoS ONE, 2012
Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance.
Pep Charusanti, Nicole L Fong, Harish Nagarajan, Alban R Pereira, Howard J Li, Elisa A Abate, Yongxuan Su, William H Gerwick, Bernhard O Palsson   +8 more
doaj   +1 more source

Production of the Sesquiterpene Bisabolene From One‐ and Two‐Carbon Compounds in Engineered Methanosarcina acetivorans

Microbial Biotechnology, Volume 18, Issue 2, February 2025.
Despite the versatile metabolic capacities of methanogenic archaea, they are currently only employed in biotechnology for their methane generating ability. We engineered Methanosarcina acetivorans to produce the sesquiterpene bisabolene from Abies grandis from methanol or from carbon monoxide.
Andrea Mentrup, Luca V. Scheitz, Theo Wallenfang, Michael Rother   +3 more
wiley   +1 more source

Análisis transcriptómico de cepas derivadas de Streptomyces clavuligerus ATCC 27064: expresión heteróloga de genes y activación de compuestos bioactivos = Transcriptomic analysis of strains obtained from Streptomyces clavuligerus atcc 27064: Heterologous gene expression and activation of bioactive compounds

, 2016
498 p.Streptomyces clavuligerus es un actinomiceto conocido por ser el productor industrial de ácido clavulánico, un potente inhibidor de β-lactamasas que se administra en combinación con antibióticos β-lactámicos para el tratamiento de diversas ...
Martínez Burgo, Yolanda
core   +1 more source

Biochemical and growth responses of mungbean to actinobacterial inoculation under water stress

Scientific Reports
Drought severely limits mungbean growth by disrupting osmotic balance, photosynthetic function, and oxidative homeostasis. This study evaluated five actinobacterial inoculants in mungbean seedlings under water deficit to clarify how microbial treatments ...
Mrugesh M. Patel, N. K. Singh, Rudra B. Parmar, Bhavesh M. Joshi, Anurag Yadav   +4 more
doaj   +1 more source

Deacetoxycephalosporin C synthase (expandase): Research progress and application potential

Synthetic and Systems Biotechnology, 2021
Cephalosporins play an indispensable role against bacterial infections. Deacetyloxycephalosporin C synthase (DAOCS), also called expandase, is a key enzyme in cephalosporin biosynthesis that epoxides penicillin to form the hexavalent thiazide ring of ...
Xiaofan Niu, Jian Zhang, Xianli Xue, Depei Wang, Lin Wang, Qiang Gao   +5 more
doaj   +1 more source

Simultaneous state‐estimator tuning and parameter estimation for systems with nonstationary disturbances, multi‐rate data, and measurement delays

The Canadian Journal of Chemical Engineering, Volume 103, Issue 1, Page 323-338, January 2025.
Abstract Model‐based monitoring and control of chemical and biochemical processes rely on state estimators such as extended Kalman filters (EKFs) to ensure accurate online model predictions. Accurate predictions depend on appropriate model parameters and suitable state‐estimator tuning factors.
Qiujun A. Liu, Kimberley B. McAuley
wiley   +1 more source

Taxonomy, purification and chemical characterization of four bioactive compounds from new Streptomyces sp. TN256 strain [PDF]

, 2011
A new actinomycete strain designated TN256, producing antimicrobial activity against pathogenic bacteria and fungi, was isolated from a Tunisian Saharan soil.
Karray-Rebai, Ines, Mathieu, Florence, F. Mathieu, L. Elleuch, Elleuch, Lobna, Merlina, Georges, Coppel, Yannick, Y. Coppel, G. Merlina, Mellouli, Lofti, S. Smaoui, Smaoui, Slim, I. Karray-Rebai, L. Mellouli   +13 more
core   +1 more source

Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus

Brazilian Archives of Biology and Technology, 2005
The aim of the present work was to compare CA production in continuous culture with and without cell recycling and in batch process by Streptomyces clavuligerus.
Álvaro Baptista-Neto, Juliana Conceição Teodoro, Luiz Claudio Macedo Cassiano Filho, Alberto Colli Badino, Carlos Osamu Hokka   +4 more
doaj   +1 more source