Results 81 to 90 of about 1,344 (153)
Angewandte Chemie, Volume 136, Issue 6, February 5, 2024.19‐nor‐Geranylgeranyldiphosphat mit entfernter Methylgruppe wurde synthetisiert und mit 20 Diterpensynthasen in Diterpenanaloga umgewandelt. In einigen Fällen wurden nur die Desmethylderivate der natürlichen Enzymprodukte erhalten, bei einigen Enzymen wurde jedoch eine dramatische Veränderung der Reaktivität beobachtet. Die neu eröffneten Reaktionswege
Kizerbo A. Taizoumbe +2 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 63, Issue 6, February 5, 2024.19‐nor‐Geranylgeranyldiphosphate (with a methyl group removed) has been synthesised and converted into diterpene analogues with 20 diterpene synthases. In some cases only the desmethyl derivatives of the natural enzyme products were obtained, but with several enzymes a dramatic change in the reactivity was observed.
Kizerbo A. Taizoumbe +2 more
wiley +1 more source
Microbial Biotechnology, Volume 17, Issue 1, January 2024.Our findings clarify the molecular mechanisms underlying functions of regulatory proteins AfsR and AfsS in Streptomyces antibiotic production and development, which are based on direct control of their target genes associated with these two important biological processes.
Yi Hao +3 more
wiley +1 more source
Dyna, 2018 The clinical and industrial importance of clavulanic acid (CA) promotes the search for novel strategies to boost productivity at lower costs. In this contribution, the production of CA was evaluated in two reference strains of Streptomyces clavuligerus ...
Laura Pinilla +4 more
doaj +1 more source
Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus, PTCC 1709 [PDF]
Cell Journal, 2011 Objective: The clavulanic acid regulatory gene (claR) is in the clavulanic acid biosyntheticgene cluster that encodes ClaR. This protein is a putative regulator of the late steps ofclavulanic acid biosynthesis.
Hasan Korbekandi +4 more
doaj
SYNTHESIS OF BENZYLPENICILLIN BY CELL-FREE EXTRACTS FROM STREPTOMYCES CLAVULIGERUS
The Journal of Antibiotics, 1986 Cell-free enzyme concentrates from Streptomyces clavuligerus were found to convert phenylacetyl-L-cysteinyl-D-valine (PCV) directly into benzylpenicillin when incubated under reaction conditions which support the activity of isopenicillin N synthetase.
S E, Jensen +4 more
openaire +3 more sources
Overproduction of clavulanic acid by extractive fermentation
Electronic Journal of Biotechnology, 2015 Background: Clavulanic acid is an important beta-lactamase inhibitor produced as a secondary metabolite by the actinomycete Streptomyces clavuligerus. Clavulanic acid is chemically unstable; therefore, it is degraded during bacterial cultivation. In this
Cecília Ladeira Lopes Costa +1 more
doaj +1 more source
Frontiers in MicrobiologyAcyl-homoserine lactones (AHLs), mediating pivotal physiological activities through quorum sensing (QS), have conventionally been considered limited to Gram-negative bacteria.
Amir Salehi-Najafabadi +6 more
doaj +1 more source
Preparation and characterization of PCL-PEG-PCL polymersomes for delivery of clavulanic acid
Cogent Medicine, 2016 The Clavulanic acid (CLV) is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. In the present study, a reliable drug delivery system using poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) (PCL-PEG ...
Hossein Danafar
doaj +1 more source
FermentationClavulanic acid is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus, widely used in combination with β-lactam antibiotics to combat antimicrobial resistance.
David Gómez-Ríos +2 more
doaj +1 more source