Results 31 to 40 of about 2,543,810 (186)

How Clavulanic Acid Inhibits Serine β‐Lactamases [PDF]

Clavulanic acid is a medicinally important inhibitor of serine β‐lactamases (SBLs). We report studies on the mechanisms by which clavulanic acid inhibits representative Ambler class A (TEM‐116), C (Escherichia coli AmpC), and D (OXA‐10) SBLs using ...
de Munnik, Mariska, Oluwole, Abraham O., Robinson, Carol V., Schofield, Christopher J., Claridge, Timothy D. W., Brem, Jürgen, Lang, Pauline A.   +6 more
core   +1 more source

Amoxicillin+clavulanic acid in community acquired pneumonia: Past, present, and future from an Indian perspective

Asian Journal of Medical Sciences, 2022
Community acquired pneumonia (CAP) is a major health problem in India with high morbidity and mortality. The threat posed by this infection is further intensified by the continued emergence of resistance to the currently available antibiotics.
Sandeep Budhiraja , Akhil Agarwal , Yashpal Chugh , Alap Gandhi , Bhavesh Kotak   +4 more
doaj   +1 more source

Clavulanic Acid Overproduction: A Review of Environmental Conditions, Metabolic Fluxes, and Strain Engineering in Streptomyces clavuligerus

Fermentation
Clavulanic acid is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus, widely used in combination with β-lactam antibiotics to combat antimicrobial resistance.
David Gómez-Ríos, Luisa María Gómez-Gaona, Howard Ramírez-Malule   +2 more
doaj   +1 more source

Successful treatment with amoxicillin-clavulanic acid: cutaneous nocardiosis caused by Nocardia brasiliensis

Journal of Dermatological Treatment, 2023
Aim To emphasize the role of non-sulfonamides in the treatment of Nocardia infection and reduce the adverse reactions caused by sulfonamides. Methods We retrospectively analyzed a case of cutaneous nocardiosis in an immunocompetent individual.
Youqi Ji, Fang Su, Xin Hong, Mengyuan Chen, Yongze Zhu, Dongqing Cheng, Yumei Ge   +6 more
doaj   +1 more source

Structural Variabilities in β-Lactamase (blaA) of Different Biovars of Yersinia enterocolitica: Implications for β-Lactam Antibiotic and β-Lactamase Inhibitor Susceptibilities. [PDF]

PLoS ONE, 2014
Yersiniosis caused by Yersinia enterocolitica has been reported from all continents. The bacterial species is divided into more than fifty serovars and six biovars viz.
Neelja Singhal, Abhishikha Srivastava, Manish Kumar, Jugsharan Singh Virdi   +3 more
doaj   +1 more source

Increase of Clavulanic acid production by using recombinant Streptomyces clavuligerus strain including claR gene

Biological Journal of Microorganism, 2014
Introduction : Clavulanic acid is a major β-lactam antibiotic which is produced by Streptomyces clavuligerus. Clavulanic acid is used in combination of strong but sensitive to β-lactamase antibiotics.
Maryam Kay, zohreh Hojati, Majid Motovali-Bashi   +2 more
doaj  

Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight Into Specialized Metabolism

Frontiers in Microbiology, 2019
Clavulanic acid is a bacterial specialized metabolite, which inhibits certain serine β-lactamases, enzymes that inactivate β-lactam antibiotics to confer resistance.
Nader F. AbuSara, Brandon M. Piercey, Marcus A. Moore, Arshad Ali Shaikh, Louis-Félix Nothias, Santosh K. Srivastava, Pablo Cruz-Morales, Pieter C. Dorrestein, Francisco Barona-Gómez, Kapil Tahlan   +9 more
doaj   +1 more source

In vitro activity of amoxycillin plus clavulanic acid and ticarcillin plus clavulanic acid compared with that of other antibiotics against anaerobic bacteria

, 1989
peer reviewedThe activity of amoxycillin/clavulanic acid (Augmentin) and ticarcillin/clavulanic acid (Timentin) was tested against 303 unselected clinical anaerobic isolates recently collected in seven Belgian university hospitals and compared with that ...
Glupczynski, Y., Delmée, Michel, Struelens, Marc, Pattyn, Stephan R, Verschraegen, G., De Meyer, A., Melin, Pierrette, Pierard, Denis, Lauwers, Sabine, Rossell, P.   +9 more
core   +1 more source

Amoxicillin/Clavulanic Acid for the Treatment of Odontogenic Infections: A Randomised Study Comparing Efficacy and Tolerability versus Clindamycin

International Journal of Dentistry, 2015
Background. Treatment of odontogenic infections includes surgical drainage and adjunctive antibiotics. This study was designed to generate efficacy and safety data to support twice daily dosing of amoxicillin/clavulanic acid compared to clindamycin in ...
Archiel Launch Tancawan, Maria Noemi Pato, Khamiza Zainol Abidin, A. S. Mohd Asari, Tran Xuan Thong, Puja Kochhar, Chandra Muganurmath, Monique Twynholm, Keith Barker   +8 more
doaj   +1 more source

Amoxycillin-Clavulanic Acid-Induced Esophageal Ulcer: An Unusual Cause

Case Reports in Gastroenterology, 2020
Pill-induced esophagitis or esophageal ulcers are considered when patients have retrosternal chest pain or odynophagia following the ingestion of suspicious medications. Various drugs have been reported to induce esophageal ulcers.
Apichat Kaewdech, Tanawat Pattarapuntakul, Pimsiri Sripongpun   +2 more
doaj   +1 more source