Results 61 to 70 of about 34,488 (237)

Current challenges in antimicrobial chemotherapy: focus on beta-lactamase inhibition. [PDF]

, 2010
peer reviewedThe use of the three classical beta-lactamase inhibitors (clavulanic acid, tazobactam, sulbactam) in combination with beta-lactam antibiotics is currently the most successful strategy to combat the beta-lactamase mediated resistance. However,
Lassaux, Patricia, Sohier, Jean, Vercheval, Lionel, Galleni, Moreno, Bebrone, Carine, Sauvage, Eric, Jehaes, Adrien   +6 more
core   +1 more source

Various Extracts of Some Medicinal Plants as Inhibitors for Beta-lactamase Activity

مجلة بغداد للعلوم, 2021
The inhibitory effect of acetone, ethanol, and aqueous extracts of ten medicinal plants on β-lactamase from Staphylococcus sciuri and Klebsiella pneumoniae was investigated in vitro by starch-iodine agar plate method.
Huda S. A. Al-Hayanni, Hamed El-Shora
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Discovery of Boronic Acids-Based β-Lactamase Inhibitors Through In Situ Click Chemistry [PDF]

In this study, we evaluated in situ click chemistry as a platform for discovering boronic acid-based β-lactamase inhibitors (BLIs). Unlike conventional drug discovery approaches requiring multi-step synthesis, protection strategies, and extensive ...
Emilia Caselli, Mariagrazia Perilli, Alessandra Piccirilli, Fabio Prati, Robert A. Bonomo, Federico Corsini, Magdalena A. Taracila, Francesco Fini, Nicolò Santi   +8 more
core   +1 more source

New leads of metallo-beta-lactamase inhibitors from structure-based pharmacophore design [PDF]

, 2006
We have applied pharmacophore generation, database searching, docking methodologies, and experimental enzyme kinetics to discover new structures for design of di-zinc metallo-beta-lactamase inhibitors. Based on crystal structures of class B1 metallo-beta-
Adolph, Hans-Werner, Olsen, Lars, Jost, Sandra, Jørgensen, Flemming Steen, Hemmingsen, Lars, Pettersson, Ingrid   +5 more
core   +1 more source

Identification of group specific motifs in Beta-lactamase family of proteins

Journal of Biomedical Science, 2009
Background Beta-lactamases are one of the most serious threats to public health. In order to combat this threat we need to study the molecular and functional diversity of these enzymes and identify signatures specific to these enzymes.
Saxena Akansha, Singh Reema, Singh Harpreet   +2 more
doaj   +1 more source

Management of clinical infections of Escherichia coli by new β-lactam/ β-lactamase inhibitor combinations

Iranian Journal of Microbiology, 2022
Background and Objectives: Escherichia coli (E. coli) is an important member of Enterobacteriaceae family involved in severe infections. The increased rate of resistance towards different classes of antibiotics limits their treatment options. The aim of
Ashraf Ahmed Kadry, May Ayman El-Antrawy, Amira Mohammed El-Ganiny   +2 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, EarlyView.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

A Tripeptide Deletion in the Class C beta-Lactamase FOX-4 Enzyme Impairs Cefoxitin Hydrolysis and Slightly Increases Susceptibility to beta-Lactamase Inhibitors [PDF]

, 2010
peer reviewedOBJECTIVES: A natural variant of the AmpC enzyme from Escherichia coli HKY28 with a tripeptide deletion (Gly-286/Ser-287/Asp-288) was recently described.
Kerff, Frédéric, Fernández-Moreira, Esteban, Galleni, Moreno, Pérez-Llarena, Francisco J., Mallo, Susana, Soares, Nelson C., Bou, German   +6 more
core   +1 more source