Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 [PDF]
Brazilian Journal of Pharmaceutical SciencesHealthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance.
Giuliana Amanda de Oliveira +1 more
doaj +1 more source
Supra and subgingival application of antiseptics or antibiotics during periodontal therapy
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero +5 more
wiley +1 more source
Antibiotics, 2023 Background: Avibactam, relebactam and vaborbactam are β-lactamase inhibitors that proved their efficiency against KPC-producing Enterobacterales. Regarding their inhibitor activity towards Ambler’s class A extended spectrum β-lactamases (ESBL) and Ambler’
Rémy A. Bonnin +6 more
doaj +1 more source
Phenotypic and in silico studies for a series of synthetic thiosemicarbazones as New Delhi metallo-beta-lactamase carbapenemase inhibitors [PDF]
, 2021 The past two decades have been marked by a global spread of bacterial resistance to β-lactam drugs and carbapenems derivatives are the ultimate treatment against multidrug-resistant bacteria.
Joice Neves Reis (9437127) +6 more
core +1 more source
Beta-Lactamase-Mediated Antibiotic Resistance in Urinary Tract Infections: Mechanisms and Therapeutic Strategies [PDF]
Urogenital Tract InfectionUrinary tract infections (UTIs) are among the most prevalent bacterial infections globally, and are primarily caused by Escherichia and Klebsiella. The overprescription and inappropriate use of antibiotics have accelerated the emergence of multidrug ...
Fanglin Shao +7 more
doaj +1 more source
Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching
Angewandte Chemie, EarlyView.Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless +5 more
wiley +2 more sources
Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors. [PDF]
, 2008 The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM.
Lassaux, Patricia +12 more
core +1 more source
Piperacillin–tazobactam as alternative to carbapenems for ICU patients
Annals of Intensive Care, 2017 Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-related infections in non-ICU ...
Benoit Pilmis +4 more
doaj +1 more source
Biomedicines, 2022 The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/carbapenemase inhibitor combinations.
Maria V. Golikova +7 more
doaj +1 more source
β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources [PDF]
, 2022 β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the increasing emergence of resistance to them, developed by bacteria producing β-lactamase enzymes (BLEs), is becoming one of the major warnings to the global ...
Silvana Alfei +3 more
core +1 more source