Results 51 to 60 of about 827,661 (196)

Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan

BMC Research Notes, 2019
Objectives Gram-negative bacilli are the common causative agents for community-acquired, nosocomial and opportunistic infections. The recent upsurge of biofilm, as well as beta-lactamases producing strains, have synergistically led to the extensive ...
Rabina Dumaru, Ratna Baral, Lok Bahadur Shrestha   +2 more
doaj   +1 more source

Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1

, 2017
Background. The emergence of bacterial strains resistant to available antibiotic armamentarium is nowadays a pressing issue in clinical therapy. Among the several mechanisms of bacterial resistance, the rapid evolution and spread of carbapenemases, β ...
Cross, Simon, Perilli, Mariagrazia, Celenza, Giuseppe, Cendron, Laura, TONDI, Donatella, Bellio, Pierangelo, SPYRAKIS, FRANCESCA, Marcoccia, Francesca   +7 more
core  

Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Nature Communications, 2020
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al.
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony   +8 more
doaj   +1 more source

Massive culture-based approach for the screening of AmpC, ESBL, and carbapenemase producers from rectal swabs

Microbiology Spectrum
Gram-negative bacilli-producing beta-lactamases are major causes of difficult-to-treat infections, especially the AmpC, extended-spectrum beta-lactamases (ESBL), and carbapenemase types. Their spread within and outside hospital settings demands effective
Gabriel Taddeucci-Rocha, Victoria de Oliveira Costa, Sarah Vitória Martins da Silva, Jéssica Britto Gonçalves, Natalia Chilinque Zambão da Silva, Marcia Maiolino Garnica, Renata Cristina Picão   +6 more
doaj   +1 more source

Identification of extended spectrum beta lactamases, AmpC and carbapenemase production among isolates of Escherichia coli in North Indian tertiary care centre

Avicenna Journal of Medicine, 2018
Introduction: Identification of Extended spectrum beta lactamases (ESBL), AmpC production and carbapenemase production among isolates of Escherichia coli, helps clinician to rationalize the choice of antibiotics.
Uma Chaudhary, Shipra Agarwal, Kausalya Raghuraman   +2 more
doaj   +1 more source

Bacterial TEM-type serine beta-lactamases: structure and analysis of mutations

, 2017
Beta-lactamases (EC 3.5.2.6) represent a superfamily containing more than 2,000 members: it includes genetically and functionally different bacterial enzymes capable to destroy the beta-lactam antibiotics.
I.V. Uporov, I.P. Andreeva, V.G. Grigorenko, A.V. Veselovsky, A.M. Egorov, M.Yu. Rubtsova, I.V. Ishtubaev, D.S. Shcherbinin   +7 more
core   +1 more source

Phenotypic Detection of Beta-Lactamases Production in Enterobacteriaceae [PDF]

, 2014
Introduction Beta-lactam antibiotics are the most commonly used antibacterial drugs. However, many bacteria have developed resistance to these antibiotics, and the most common form of resistance. is the production of beta-lactamase enzymes.
Ćirković, Ivana, Kostić, Katarina, Konstantinović, Neda M., Đukić, Slobodanka, Pavlović, Ljiljana, Jovanović, Snežana   +5 more
core   +1 more source

Identification of 76 novel B1 metallo-beta-lactamases through large-scale screening of genomic and metagenomic data [PDF]

, 2017
Background: Metallo-beta-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and
Österlund, Tobias, Fanny Berglund, Carl-Fredrik Flach, Berglund, Fanny, D G Joakim Larsson, Larsson, D. G. Joakim, Kotsakis, Stathis,, Nachiket P. Marathe, Berglund, Fanny,, Kotsakis, S., Kristiansson, Erik,, Bengtsson Palme, Johan,, Kristiansson, Erik, Marathe, Nachiket,, Marathe, Nachiket, Flach, Carl-Fredrik,, Österlund, Tobias,, Bengtsson-Palme, Johan,, Erik Kristiansson, Johan Bengtsson-Palme, 6sterlund, Tobias, Larsson, D. G. Joakim,, Tobias Österlund, Bengtsson-Palme, Johan, Stathis Kotsakis, Flach, Carl-Fredrik   +25 more
core   +1 more source

Evaluation of phenotypic tests for the detection of AmpC beta-lactamase in clinical isolates of Escherichia coli

Indian Journal of Pathology and Microbiology, 2013
Background: AmpC beta lactamases are cephalosporinases that confer resistance to a wide range of beta lactam drugs thereby causing serious therapeautic problem.
Deepika Handa, Anita Pandey, Ashish Kumar Asthana, Ashutosh Rawat, Seemant Handa, Bhaskar Thakuria   +5 more
doaj   +1 more source

Phenotypic characterization of beta-lactamases producing Gram-negative bacteria in a tertiary hospital, Nepal

Nepal Journal of Biotechnology, 2019
Infections caused by beta-lactamases producing Gram-negative bacteria are increasing, thus posing a challenge to the management of such infections.
Elina Maharjan, Pooja Shakya, Balkrishna Bhattachan, Bharat Prasad Baral, Dhiraj Shrestha   +4 more
doaj   +1 more source