Results 51 to 60 of about 781,021 (270)
Advanced Science, EarlyView.High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld +5 more
wiley +1 more source
Inhibitors of metallo-beta-lactamases
, 2020 The present invention relates to compounds that function as inhibitors of metallo-beta-lactamases (MBL). The present invention also relates to pharmaceutical compositions comprising such MBL inhibitors, and uses thereof in the treatment of bacterial ...
Legru, Alice +4 more
core +2 more sources
Journal of Applied Oral Science, 2007 Endodontic infections are mixed aerobic-anaerobic infections and several microbial groups associated to these pathologies are also involved in orofacial infections. The goal of this study was to evaluate the susceptibility of microorganisms isolated from
Elerson Gaetti-Jardim Júnior +4 more
doaj +1 more source
Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. [PDF]
, 2011 peer reviewedThe metallo-β-lactamase (MBL) GOB-1 was expressed via a T7 expression system in Escherichia coli BL21(DE3). The MBL was purified to homogeneity and shown to exhibit a broad substrate profile, hydrolyzing all the tested β-lactam compounds ...
Nathalie Selevsek +26 more
core +1 more source
Advanced Science, EarlyView.Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao +6 more
wiley +1 more source
Exposure assessment of extended-spectrum beta-lactamases/AmpC beta-lactamases-producing in meat in Denmark [PDF]
, 2013 Extended-Spectrum Beta-Lactamases (ESBL) and AmpC Beta-Lactamases (AmpC) are of great concern because of their ability to cause antimicrobial resistance in Enterobacteriaceae hampering the effect of treatment with beta-lactam antibiotics.
da Costa, P. +3 more
core +1 more source
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved.
Yasir F. Muhsin +2 more
doaj +1 more source
Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases [PDF]
, 1999 peer reviewedThe most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders of magnitude.
Valladares, M. H. +19 more
core +1 more source
Advanced Science, EarlyView.Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair +3 more
wiley +1 more source