Results 71 to 80 of about 893,574 (181)

Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis

Frontiers in Cellular and Infection Microbiology, 2023
Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis.
Chenchen Song, Xuan Sun, Xuan Sun, Yao Wang, Leif Bülow, Michael Mecklenburg, Changxin Wu, Qinglai Meng, Bin Xie   +8 more
doaj   +1 more source

Restoring Meropenem Activity Against VIM‐1‐Producing Klebsiella pneumoniae Through Zinc‐Binding Ligands

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
Approved zinc‐binding drugs and newly synthesized HisPyr ligands were evaluated as adjuvants to meropenem against metallo‐β‐lactamase‐producing Klebsiella pneumoniae. Chlorpropamide and D‐penicillamine restored meropenem activity against the VIM‐1‐producing strain, while computational analyses supported interactions with the enzyme's binuclear zinc ...
Chiara Ragusa, Ruqaiya Khalil, Valentina Giglio, Kaveh Eskandari, Fraser J. Scott, Attilio V. Vargiu, Graziella Vecchio   +6 more
wiley   +1 more source

Combination of Oral Doxycycline and Rifampin for Pan‐Drug Resistant Klebsiella pneumoniae Infection: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Pan‐drug resistant Klebsiella pneumoniae is a major therapeutic challenge, particularly when standard last‐line agents are unavailable or contraindicated. We report a 45‐year‐old man with multifocal osteomyelitis and persistent purulent wound discharge despite broad‐spectrum antibiotics, repeated debridement, and two sequential amputations ...
Ali Akbar Heydari, Sepideh Elyasi, Farshad Abedi   +2 more
wiley   +1 more source

Detection of OXA‐23 Among Carbapenem‐Resistant Acinetobacter baumannii Isolated From Intensive Care Units of a Tertiary Care Hospital in Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Graphical Abstract of the Experimental Workflow for CRAB Isolate Characterization. ABSTRACT Carbapenem‐resistant Acinetobacter baumannii (CRAB) has been designated a top‐priority critical pathogen by the World Health Organization, and the CDC has also classified it as a serious and immediate public health threat. The Cross‐sectional study was conducted
Hafsa Waseem, Ihsan Ullah, Shahzad Ahmad, Irfan Ali Mirza, Benish Aleem, Shazia Iqbal   +5 more
wiley   +1 more source

Phenotypic detection of Metallo- and AmpC β-lactamases producing strains of P. aeruginosa in the state of Himachal Pradesh (India) [PDF]

Al Ameen Journal of Medical Sciences, 2015
Background: A prospective study was undertaken to detect metallo-β-lactamases (MBLs) and AmpC β-lactamases in Pseudomonas aeruginosa isolates recovered from patients at Indira Gandhi Medical College, Shimla (H.P).
Naveen Minhas, Prakash Chand Sharma
doaj  

Genomic Epidemiology of Multidrug‐Resistant Clinical Klebsiella pneumoniae From Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Study design and bioinformatics workflow. Cohort selection and uniform workflow. ABSTRACT Background Antimicrobial‐resistant Klebsiella pneumoniae is a major clinical threat in Pakistan and the wider South Asian region, where genomic surveillance remains limited. We analyzed 122 publicly available human clinical K.
Hakeem Zada, Muhammad Qasim, Mubashir Hussain, Abdul Rehman, Hassan Naveed, Noor Bahadar, Najibullah Anwari   +6 more
wiley   +1 more source

Metallo-β-lactamases: a last frontier for β-lactams?

, 2011
Metallo-β-lactamases are resistance determinants of increasing clinical relevance in Gram-negative bacteria. Because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all β ...
CORNAGLIA, Giuseppe, Rossolini GM, ROSSOLINI G. M., CORNAGLIA G., GIAMARELLOU H., Giamarellou H   +5 more
core   +1 more source

The characterization of a new stabilized lactonase from the endophytic fungi Aspergillus pseudonomiae with anti‐bacterial and anti‐fungal properties

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microorganisms use diverse small‐molecule signals to coordinate behavior, supporting interspecies and interkingdom communication. These chemical dialogs shape fundamental biological processes and define interactions from cooperation to antagonism.
Dor Ben Tovim, Olena Trofimyuk, Elon Yariv, Gali Prag, Livnat Afriat‐Jurnou   +4 more
wiley   +1 more source

Vibrio Community Structure Shapes the Diversity of Carbenicillin‐Hydrolysing Class A β‐Lactamase Circulating in European Coastal Environments

Environmental Microbiology, Volume 28, Issue 8, August 2026.
Vibrio communities shape carbenicillinase diversity in European coasts. Sediments serve as reservoirs of antibiotic‐resistant Vibrio alginolyticus, which can move into the water column and accumulate in bivalves. This spreads β‐lactamase resistance and raises human exposure risks to antibiotic‐resistant pathogenic Vibrio, especially as higher seawater ...
Berenice Reggiardo, Jamal Saad, Marie‐Agnès Travers, Yannick Labreuche, David Goudenège, Eve Toulza, Coralie Broquard, Karl B. Andree, Julia Mougin, Nicolas Argenta, Gaëlle Courtay, Juliette Pouzadoux, Océane Romatif, Audrey Caro, Dolors Furones, Luigi Vezzulli, Gianluca Corno, Andrea Di Cesare, Ignasi Gairin, Bruno Petton, K. Mathias Wegner, Caroline Montagnani, Viviane Boulo, Delphine Destoumieux‐Garzón   +23 more
wiley   +1 more source

Environmental species from theTelluria group as the putative origin of bifunctionalβ-lactamases

Microbiology Spectrum
β-Lactamases comprise two structurally and evolutionarily well-defined groups: serine- (SBL) and metallo-β-lactamases (MBL). To date, clinically relevant β-lactamases are typically monofunctional DD-peptidases, containing a single active site cavity per ...
Pedro Penzotti, Gabriel Gutkind, Rachel A. Powers, Pablo Power   +3 more
doaj   +1 more source