Results 71 to 80 of about 52,332 (219)

A blaVIM-2 Plasmid Disseminating in Extensively Drug-Resistant Clinical Pseudomonas aeruginosa and Serratia marcescens Isolates [PDF]

, 2014
Infections caused by carbapenem-resistant Enterobacteriaceae isolates are an issue of major global concern (1). Genes coding for metallo-β-lactamases (MβLs) identified in clinical isolates are associated with mobile elements and subject to horizontal ...
Centron, Daniela, Deraspe, Maxime, Famiglietti, Angela María Rosa, Kovensky, Jaime, Pistorio, Mariano, Quiroga, Cecilia, Raymond, Frédéric, Rodriguez, Hernan Bernardo, Roy, Paul H., Vilacoba, Elisabet   +9 more
core   +2 more sources

AMA overcomes antibiotic resistance by NDM and VIM metallo-β-lactamases

Nature, 2014
The emergence and spread of carbapenem-resistant Gram-negative pathogens is a global public health problem. The acquisition of metallo-β-lactamases (MBLs) such as NDM-1 is a principle contributor to the emergence of carbapenem-resistant Gram-negative ...
Andrew M. Q. King, Sarah A. Reid-Yu, Wenliang Wang, D. King, Gianfranco De Pascale, N. Strynadka, T. Walsh, B. Coombes, Gerard D. Wright   +8 more
semanticscholar   +1 more source

Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are ...
Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi   +2 more
doaj   +1 more source

Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China. [PDF]

, 2019
BACKGROUND: Carbapenems are β-lactam antibiotics which are used to treat severe infections caused by multidrug resistant Enterobacteriacea. The recent emergence and rapid spread of Enterobacteriaceae resistant to carbapenems is a global concern.
Ding, Y, Heath, PT, Hsia, Y, Sharland, M, Wang, Y   +4 more
core   +1 more source

MOESM5 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 5: Table S4. Potential Virulence factors identified in the Chryseobacterium indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Naringin inhibits the biofilms of metallo-β-lactamases (MβLs) producing Pseudomonas species isolated from camel meat

Saudi Journal of Biological Sciences, 2020
Food producing animals harbouring bacteria carrying drug resistance genes especially the metallo-beta-lactamase (MBL) pose high risk for the human population.
F. Husain, K. Perveen, F. A. Qais, I. Ahmad, A. Alfarhan, M. El-Sheikh   +5 more
semanticscholar   +1 more source

Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae

Frontiers in Pharmacology
The development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infections of extended ...
Wesam H. Abdulaal, Nabil A. Alhakamy, Nabil A. Alhakamy, Nabil A. Alhakamy, Amer H. Asseri, Amer H. Asseri, Mohamed F. Radwan, Tarek S. Ibrahim, Solomon Z. Okbazghi, Hisham A. Abbas, Basem Mansour, Aly A. Shoun, Wael A. H. Hegazy, Wael A. H. Hegazy, Mahmoud Saad Abdel-Halim   +14 more
doaj   +1 more source

Additional file 2: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Updated Charlson index score. (DOCX 14 kb)
Persoon, Marjolein, Holt, Anne Voor In, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, JuliĂŤtte Severin   +6 more
openaire   +1 more source

β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources

Pharmaceuticals, 2022
β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the increasing emergence of resistance to them, developed by bacteria producing β-lactamase enzymes (BLEs), is becoming one of the major warnings to the global public health.
Silvana Alfei, Anna Maria Schito
doaj   +1 more source

New antimicrobials [PDF]

, 2017
Since 2010 the new antimicrobials introduced have activity against resistant Gram negative bacteria, long half-lives against Gram positive bacteria, better activity against Clostridium difficile, and safer antifungal properties. Limiting factors to using
Roland, Will
core   +1 more source