Results 91 to 100 of about 52,332 (219)

Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis

Frontiers in Cellular and Infection Microbiology, 2023
Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis.
Chenchen Song, Xuan Sun, Xuan Sun, Yao Wang, Leif Bülow, Michael Mecklenburg, Changxin Wu, Qinglai Meng, Bin Xie   +8 more
doaj   +1 more source

Asp-120 Locates Zn2 for Optimal Metallo-β-lactamase Activity [PDF]

, 2007
Metallo-β-lactamases are zinc-dependent hydrolases that inactivate β-lactam antibiotics, rendering bacteria resistant to them. Asp-120 is fully conserved in all metallo-β-lactamases and is central to catalysis.
Bennett, Brian, Fabiane, Stella M., Kowalski, Jason M., Llarrull, Leticia l., Sutton, Brian J., Vila, Alejandro J.   +5 more
core   +1 more source

MOESM1 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 1: Table S1. Antimicrobial susceptibility profiles of C. indologenes J31.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Performance of the BioFire FilmArray Pneumonia Panel Plus Compared to Standard Microbiology in Lung Transplant Donor and Recipient Samples: A Prospective Cohort Study

Transplant Infectious Disease, EarlyView.
A prospective study demonstrating that the BioFire Pneumonia Panel Plus shows substantial concordance with culture in donor samples and moderate concordance in recipient samples, supporting its potential role in guiding perioperative antibiotic prophylaxis in lung transplantation.
Andrea Lombardi, Giulia Renisi, Lorenzo Rosso, Letizia Morlacchi, Jacopo Fumagalli, Lisa Cariani, Ilaria Righi, Valeria Rossetti, Arianna Liparoti, Cecilia Azzarà, Davide Mangioni, Laura Alagna, Paola Saltini, Maria Francesca Liporace, Chiara Abbruzzese, Annapaola Callegaro, Francesco Blasi, Giacomo Grasselli, Mario Nosotti, Alessandra Bandera   +19 more
wiley   +1 more source

Contamination of Hospital Water Supplies in Gilan, Iran, with Legionella pneumophila, Escherichia coli, and Pseudomonas aeruginosa

Interdisciplinary Perspectives on Infectious Diseases, 2015
This study is designed to determine the contamination degree of hospital water supplies with Pseudomonas aeruginosa, Legionella pneumophila, and E. coli in Gilan, Iran.
Masoumeh Ahmadi Jalali Moghadam, Hamidreza Honarmand, Sajad Asfaram Meshginshahr   +2 more
doaj   +1 more source

Metallo β-lactamases: A perspective and implications

Medical Journal of Dr. D.Y. Patil University, 2012
The emergence of Carbapenem-resistant organisms from the family Enterobacteriaceae is a major challenge in the intensive care facilities. They produce carbapenemases which inhibit carbapenems belonging to the Ambler classification group B and they depend
Rabindra N Misra
doaj   +1 more source

Evidence for a Dinuclear Active Site in the Metallo-β-lactamase BcII with Substoichiometric Co(II): A New Model for Uptake [PDF]

, 2007
Metallo-β-lactamases are zinc-dependent enzymes that constitute one of the main resistance mechanisms to β-lactam antibiotics. Metallo-β-lactamases have been characterized both in mono- and dimetallic forms.
Bennett, Brian, Kowalski, Jason M., Llarrull, Leticia l., Tioni, Mariana F., Vila, Alejandro J.   +4 more
core   +1 more source

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes [PDF]

, 2016
Metallo-β-lactamases (MBLs) hydrolyze almost all β-lactam antibiotics and are unaffected by clinically available β-lactamase inhibitors (βLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of βLIs ...
Bonomo, Robert A., Castillo, Valerie, Gonzalez, Javier M., Gonzalez, Mariano M., Hinchliffe, Philip, Kosmopoulou, Magda, Llarrull, Leticia, Mahler, Graciela, Mojica, Maria F., Saiz, Cecilia, Spencer, Jim, Tooke, Catherine, Villa, Alejandro J.   +12 more
core   +3 more sources

MOESM2 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 2: Table S2. Numerous antibiotic resistance genes predicted in the C. indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Phenotypic and Genotypic Study of Antibiotic Resistance blaPER‐1, blaVEB, and blaSHV‐1 Genes in Clinical Isolates of Pseudomonas aeruginosa

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Pseudomonas aeruginosa is a non‐fermentative, opportunistic Gram‐negative bacterium that causes 10%–15% of nosocomial and burn wound infections worldwide. This bacterium is resistant to various antibiotics through multiple mechanisms, including acquisition of resistance genes.
Milad Gholampour Matin, Reza Shapouri, Mohammadreza Nahaei, Mojtaba Mohammadi Roknabadi, Rasoul Shokri   +4 more
wiley   +1 more source