Results 91 to 100 of about 893,574 (181)

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Draft genome sequence of Elizabethkingia meningoseptica isolated from a traumatic wound [PDF]

, 2014
We report the draft genome assembly of Elizabethkingia meningoseptica strain 502. The sample was isolated from the wound of a repatriated military serviceperson who suffered major trauma from an improvised explosive device (IED), resulting in wounds with
Quick, Joshua, Loman, Nicholas J, Oppenheim, Beryl, Constantinidou, Chrystala, Pallen, Mark J, Pallen, Mark J., Loman, Nicholas J.   +6 more
core   +1 more source

"Golden Era of Antibiotics" - Coming to an end !!!

SRM Journal of Research in Dental Sciences, 2012
Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini, T S Subashini, K S Sridevi Sangeetha, R Shivakumar, Nafeesa Iqbal   +4 more
doaj  

Resistance to ceftazidime–avibactam and other new β-lactams in Pseudomonas aeruginosa clinical isolates: a multi-center surveillance study

Microbiology Spectrum
New β-lactam–β-lactamase inhibitor combinations represent last-resort antibiotics to treat infections caused by multidrug-resistant Pseudomonas aeruginosa.
Felice Valzano, Gianfranco La Bella, Teresa Lopizzo, Anna Curci, Laura Lupo, Elisabetta Morelli, Adriana Mosca, Marianna Marangi, Raffaela Melfitano, Tiziana Rollo, Rosella De Nittis, Fabio Arena   +11 more
doaj   +1 more source

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

Nature Communications, 2017
New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme ...
Han Feng, Xuehui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang, Wei Liu   +5 more
doaj   +1 more source

Assay platform for clinically relevant metallo-β-lactamases. [PDF]

, 2013
Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate ...
Fishwick, CWG, Rydzik, AM, Salimraj, R, van Berkel, SS, Owens, Raymond, Owens, RJ, Fishwick, CW, Verma, A, Cain, R, Schofield, CJ, Brem, J, Spencer, J, Schofield, Christopher   +12 more
core   +1 more source

Zinc-Bound Thiolate−Disulfide Exchange:  A Strategy for Inhibiting Metallo-β-lactamases

, 2016
The mononuclear zinc thiolate complexes [(TpPhMe)Zn(S-R)], where TpPhMe is hydrotris((3-methyl-5-phenyl)pyrazolyl)borate and (S-R) is benzyl thiolate, 4-nitrophenylthiolate, 4-trifluoromethylphenylthiolate, 4-chlorophenylthiolate, phenylthiolate, 2 ...
Heidi Boerzel (2967024), Weiming Bu (184333), Stephen J. Lippard (1233759), Bernhard Spingler (1507018), Margery Koeckert (2967021)   +4 more
core   +2 more sources

Detection of metallo-β-lactamases-encoding genes among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital, Kathmandu, Nepal

BMC Research Notes, 2017
Objectives This study was carried out to determine the prevalence of metallo-β-lactamases (MBLs) producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to detect MBL-encoding genes among MBLs-positive isolates.
Mahesh Acharya, Prabhu R. Joshi, Kamal Thapa, Rajan Aryal, Trishna Kakshapati, Supriya Sharma   +5 more
doaj   +1 more source

Hydrolysis of β-Lactam Antibiotics Catalyzed by Dinuclear Zinc(II) Complexes:  Functional Mimics of Metallo-β-lactamases

, 2016
Three stable dinuclear zinc(II) complexes, [Zn2L1(μ-NO3)(NO3)2] and [Zn2L1(μ-OMe)(NO3)2], where L1 is 2,6-bis{[N-(2-dimethylaminoethyl)-N-methyl]aminomethyl}-4-methylphenolate, and [Zn2L2(NO3)3], where L2 is 2-{[N-(2-dimethylaminoethyl)-N-methyl ...
Natalia V. Kaminskaia (2961330), Stephen J. Lippard (1233759), Bernhard Spingler (1507018)   +2 more
core   +3 more sources

Protein determinants of dissemination and host specificity of metallo-β-lactamases

Nature Communications, 2019
Metallo-β-lactamases (MBLs) confer resistance to carbapenem antibiotics. Here, López et al. show that the host range of MBLs depends on the efficiency of MBL signal peptide processing and secretion into outer membrane vesicles, which affects bacterial ...
Carolina López, Juan A. Ayala, Robert A. Bonomo, Lisandro J. González, Alejandro J. Vila   +4 more
doaj   +1 more source