Results 101 to 110 of about 893,574 (181)

A Novel β-lactam/β-lactamase Inhibitor: Ceftolozane/tazobactam

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2019
Ceftolozane/tazobactam is a novel generation cephalosporin and β-lactamase inhibitor combination antibiotic. It was approved for the treatment of adults (18 years and older) with complicated intraabdominal infections used in combination with ...
Kıvanç ŞEREFHANOĞLU
doaj   +1 more source

Zinc and antibiotic resistance: metallo-β-lactamases and their synthetic analogues

, 2008
Antibiotic resistance to clinically employed β-lactam antibiotics currently poses a very serious threat to the clinical community. The origin of this resistance is the expression of several β-lactamases that effectively hydrolyze the amide bond in β ...
Mugesh, Govindasamy, Tamilselvi, A.
core   +1 more source

Post-Transplant Fecal Carriage of Antibiotic Resistant and β-Lactamases-Producing Enterobacteriales among Renal Transplant Recipients

Journal of Nepal Health Research Council
Background: The intestinal colonization and transmission of antibiotic-resistant Enterobacteriales to renal transplant recipients may pose a threat to them because they are profoundly immunocompromised and vulnerable to infection.
Bindira Joshi, Santosh Kumar Yadav, Manju Shree Shakya Hada, Sabina Shrestha, Kalpana Kumari Shrestha, Pukar Chandra Shrestha, Bal Krishna Awal   +6 more
doaj   +1 more source

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Nature Communications, 2017
Carbapenem-resistant bacteria pose a major health threat by expressing metallo-β-lactamases (MβLs), enzymes able to hydrolyse these life-saving drugs. Here the authors use biophysical and computational methods and show that different MβLs share the same ...
María-Natalia Lisa, Antonela R. Palacios, Mahesh Aitha, Mariano M. González, Diego M. Moreno, Michael W. Crowder, Robert A. Bonomo, James Spencer, David L. Tierney, Leticia I. Llarrull, Alejandro J. Vila   +10 more
doaj   +1 more source

An overview of the production of AmpC and Metallo-β-Lactamase enzymes in Escherichia coli [PDF]

Medical Laboratory Journal
Escherichia coli is a Gram-negative, rod-shaped bacterium, responsible for 90% of all community-acquired infections and 50% of hospital-acquired infections, with opportunistic infections found in intensive care unit (ICU) patients.
Kirandeep Kaur
doaj  

The role of aztreonam in rational antibacterial therapy of resistant nosocomial gram-negative infections. The new life for a well-known β-lactam

Медицина неотложных состояний
Background. The situation regarding the prevalence of resistant pathogens, types of β-lactamase products, and, accordingly, the justification of rational approaches to antibacterial therapy in Ukraine remains insufficiently studied.
V.A. Korsunov, M.A. Georgiyants, N.I. Zozulia, I.Yu. Odynets, M.B. Pushkar, M.V. Lyzogub, N.M. Bohuslavska, O.L. Onikiienko   +7 more
doaj   +1 more source

N‑Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Drug-resistant pathogens pose a global challenge to public health as they cause diseases that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc-containing enzymes that catalyze the hydrolysis of β-lactam drugs ...
Marco J. Rotter (12114333), Rolf W. Hartmann (124550), Ewgenij Proschak (34926), Samir Yahiaoui (1284564), Jelena Konstantinović (1320018), Anastasia Andreas (8985119), Anna K. H. Hirsch (7491110), Steffen Brunst (7391504), Jörg Haupenthal (1716625), Lilia Weizel (1373694), Jan S. Kramer (4677838), Rolf Müller (1426348), Cansu Kaya (12114330), Thomas A. Wichelhaus (11127528), Andreas M. Kany (4403344), Denia Frank (1613254)   +15 more
core   +2 more sources

Assay Platform for Clinically Relevant Metallo-β-lactamases

, 2015
Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate ...
James Spencer (554121), Christopher J. Schofield (233097), Anil Verma (268301), Anna M. Rydzik (765319), Raymond J. Owens (1300074), Colin W. G. Fishwick (659781), Sander S. van Berkel (1300080), Ramya Salimraj (1300077), Ricky Cain (1300071), Jürgen Brem (1300083)   +9 more
core   +1 more source

Strategies to Name Metallo-β-Lactamases and Number Their Amino Acid Residues. [PDF]

Antibiotics (Basel), 2023
Oelschlaeger P, Kaadan H, Dhungana R.
europepmc   +1 more source

Urinary tract infections caused by Gram-negative bacteria in elderly hospitalized patients: Epidemiology, clinical features and outcomes in the era of antimicrobial resistance

Journal of Global Antimicrobial Resistance
Objective: Urinary tract infections (UTI) are among the most common infections in elderly hospitalized patients, often caused by multi-drug resistant (MDR) organisms and characterized by poor clinical outcomes.
Gabriele Giuliano, Giulia Hankache, Margherita Sambo, Maria Grazia Cusi, Pietro Enea Lazzerini, Luigi Gennari, Massimiliano Fabbiani, Francesca Montagnani, Mario Tumbarello   +8 more
doaj   +1 more source