Results 111 to 120 of about 52,332 (219)

Prevalence of Clinically Isolated Metallo-beta-lactamase-producing Pseudomonas aeruginosa, Coding Genes, and Possible Risk Factors in Iran [PDF]

, 2018
Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria.
Ghasemian, Abdolmajid., Nojoomi, Farshad., Rajabi Vardanjani, Hassan., Salimian Rizi, Kobra.   +3 more
core  

Prevalência e evolução clínica de episódios de pneumonia associada à ventilação mecânica causada por Pseudomonas aeruginosa resistente a imipenem produtoras e não-produtoras de SPM-1 [PDF]

, 2011
INTRODUCTION: Pseudomonas aeruginosa is a leading cause of ventilator-associated pneumonia (VAP) and exhibits high rates of resistance to several antimicrobial drugs. The carbapenens are usually the drugs of choice against this microorganism.
Furtado, Guilherme Henrique Campos, Gales, Ana Cristina, Medeiros, Eduardo Alexandrino Servolo de, Perdiz, Luciana Baria, Santos, Anderson Fernandes   +4 more
core   +2 more sources

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

Biochemistry, 2018
There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs), enzymes that hydrolyze β-lactam antibiotics and confer resistance to Gram-negative bacteria. Here we present 6-phosphonomethylpyridine-2-carboxylates (PMPCs) as potent
P. Hinchliffe, Carol A Tanner, Anthony P Krismanich, G. Labbé, V. Goodfellow, L. Marrone, Ahmed Y. Desoky, Karina Calvopiña, Emily E. Whittle, Fanxing Zeng, M. Avison, N. Bols, Stefan Siemann, J. Spencer, G. Dmitrienko   +14 more
semanticscholar   +1 more source

The Evaluation of Machine Learning Models Using Matrix‐Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI–TOF–MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Machine learning models developed from matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry spectra can rapidly predict antimicrobial resistance in Klebsiella pneumoniae. By transforming routine spectral data into accurate resistance profiles within minutes, this approach could reduce diagnostic delays and support earlier ...
Stephen Mark Edward Fordham
wiley   +1 more source

A close look onto structural models and primary ligands of metallo-β-lactamases.

Drug resistance updates, 2018
β-Lactamases are hydrolytic enzymes capable of opening the β-lactam ring of antibiotics such as penicillin, thus endowing the bacteria that produce them with antibiotic resistance.
J. Raczynska, I. Shabalin, W. Minor, A. Wlodawer, M. Jaskólski   +4 more
semanticscholar   +1 more source

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases

Pharmaceuticals, 2020
The emergence of bacteria that co-express serine- and metallo- carbapenemases is a threat to the efficacy of the available β-lactam antibiotic armamentarium.
P. Linciano, E. Gianquinto, M. Montanari, L. Maso, P. Bellio, E. Cebrián-Sastre, G. Celenza, J. Blázquez, L. Cendron, F. Spyrakis, D. Tondi   +10 more
semanticscholar   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

bZIP63.5 Regulates a Zinc‐Finger Mediated Detoxification Network in Trichoderma Harzianum for Enhanced Biocontrol of Alternaria alternata

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
The bZIP63.5 transcription factor, activated by Alternaria alternata stress, directly upregulates zinc‐finger transcription factors (Zn2CyS6 and C2H2 types), which in turn enhance the expression of downstream detoxification and defence‐related genes, collectively improving the biocontrol efficacy of Trichoderma harzianum.
Yongfeng Yang, Huifang Zhang, Bin Liu, Jing Han, Ning Kong, Jingwen Gao, Zhihua Liu   +6 more
wiley   +1 more source

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Clonal diversity of Acinetobacter baumannii from diabetic patients in Saudi Arabian hospitals [PDF]

, 2014
Carbapenem-resistant Acinetobacter baumannii (CR-AB) represents a major health-care problem causing high rates of morbidity and mortality. This study investigated the clonality of CR-AB isolated from diabetic patients from different regions in Saudi ...
Abdalhamid, Abdulrahman A. Alsultan, Baadani, Benjamin A. Evans, Dijkshoorn, Elsayed Aboulmagd, Lambiase, Miranda, Mohajeri, Sebastian G. B. Amyes, Shahcheraghi, Souli   +11 more
core   +2 more sources