Results 51 to 60 of about 893,574 (181)

MOESM5 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 5: Table S4. Potential Virulence factors identified in the Chryseobacterium indologenes J31 genome.
Wang, Tingting, Jiang, Xiawei, Feng, Chunyan, Li, Ang, Dong, Huihui, Wu, Shaoqiang, Zheng, Beiwen   +6 more
openaire   +1 more source

Redirecting pantoprazole as a metallo-beta-lactamase inhibitor in carbapenem-resistant Klebsiella pneumoniae

Frontiers in Pharmacology
The development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infections of extended ...
Wesam H. Abdulaal, Nabil A. Alhakamy, Nabil A. Alhakamy, Nabil A. Alhakamy, Amer H. Asseri, Amer H. Asseri, Mohamed F. Radwan, Tarek S. Ibrahim, Solomon Z. Okbazghi, Hisham A. Abbas, Basem Mansour, Aly A. Shoun, Wael A. H. Hegazy, Wael A. H. Hegazy, Mahmoud Saad Abdel-Halim   +14 more
doaj   +1 more source

Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are ...
Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi   +2 more
doaj   +1 more source

MOESM6 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 6: Table S5. Four conjugative transposon gene clusters in the Chryseobacterium indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

, 2019
The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1 and ...
Philip Hinchliffe (1483897), Karina Calvopiña (4923838), Pauline A. Lang (7314608), Tharindi D. Panduwawala (7388438), Jos J. A. G. Kamps (6436754), Jürgen Brem (1300083), Jonathan M. Tyrrell (7388441), James Spencer (554121), Christopher J. Schofield (233097), Alen Krajnc (7388435), Emma Widlake (7388444), Benjamin G. Saward (7388447), Timothy R. Walsh (5217941)   +12 more
core   +2 more sources

MOESM7 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 7: Table S6. List of genome accessions used in whole-genome phylogenetic analysis.
Wang, Tingting, Jiang, Xiawei, Feng, Chunyan, Li, Ang, Dong, Huihui, Wu, Shaoqiang, Zheng, Beiwen   +6 more
openaire   +1 more source

MOESM1 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 1: Table S1. Antimicrobial susceptibility profiles of C. indologenes J31.
Wang, Tingting, Jiang, Xiawei, Feng, Chunyan, Li, Ang, Dong, Huihui, Wu, Shaoqiang, Zheng, Beiwen   +6 more
openaire   +1 more source

β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources

Pharmaceuticals, 2022
β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the increasing emergence of resistance to them, developed by bacteria producing β-lactamase enzymes (BLEs), is becoming one of the major warnings to the global public health.
Silvana Alfei, Anna Maria Schito
doaj   +1 more source

MOESM2 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 2: Table S2. Numerous antibiotic resistance genes predicted in the C. indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source