Results 11 to 20 of about 52,332 (219)

Drug development concerning metallo-β-lactamases in gram-negative bacteria [PDF]

Frontiers in Microbiology, 2022
β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production of serine- and metallo-β-
Xiuyun Li, Jing Zhao, Bin Zhang, Xuexia Duan, Jin Jiao, Weiwei Wu, Yuxia Zhou, Hefeng Wang   +7 more
doaj   +3 more sources

Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution [PDF]

Antibiotics, 2014
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able
María-Rocío Meini, Leticia I. Llarrull, Alejandro J. Vila   +2 more
doaj   +5 more sources

Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

Microbiome, 2017
Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund, Nachiket P. Marathe, Tobias Österlund, Johan Bengtsson-Palme, Stathis Kotsakis, Carl-Fredrik Flach, D G Joakim Larsson, Erik Kristiansson   +7 more
doaj   +2 more sources

Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors

Communications Chemistry
Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics ...
Kinga Virág Gulyás, Liping Zhou, Daniel Salamonsen, Andreas Prester, Kim Bartels, Robert Bosman, Paul Haffke, Jintian Li, Viola Tamási, Fritz Deufel, Johannes Thoma, Anna Andersson Rasmussen, Miklós Csala, Hanna-Kirsti Schroder Leiros, Zhijian Xu, Mikael Widersten, Holger Rohde, Eike C. Schulz, Weiliang Zhu, Máté Erdélyi   +19 more
doaj   +6 more sources

Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context [PDF]

EBioMedicine
Summary: Background: The global emergence and spread of carbapenem-resistant Enterobacteriaceae in clinical settings have driven the search for inhibitors that can counteract carbapenemases.
Yan Zhang, Siyuan Yang, Zhaoju Deng, Huangwei Song, Ning Xie, Yunrui Tian, Shangshang Qin, Jifeng Liu, Yong Guo, Dongli Wang, Junfeng Liu, Congming Wu, Jianzhong Shen, Shizhen Ma, Yang Wang, Dejun Liu   +15 more
doaj   +2 more sources

Protein determinants of dissemination and host specificity of metallo-β-lactamases

Nature Communications, 2019
Metallo-β-lactamases (MBLs) confer resistance to carbapenem antibiotics. Here, López et al. show that the host range of MBLs depends on the efficiency of MBL signal peptide processing and secretion into outer membrane vesicles, which affects bacterial ...
Carolina López, Juan A. Ayala, Robert A. Bonomo, Lisandro J. González, Alejandro J. Vila   +4 more
doaj   +2 more sources

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Nature Communications, 2017
Carbapenem-resistant bacteria pose a major health threat by expressing metallo-β-lactamases (MβLs), enzymes able to hydrolyse these life-saving drugs. Here the authors use biophysical and computational methods and show that different MβLs share the same ...
María-Natalia Lisa, Antonela R. Palacios, Mahesh Aitha, Mariano M. González, Diego M. Moreno, Michael W. Crowder, Robert A. Bonomo, James Spencer, David L. Tierney, Leticia I. Llarrull, Alejandro J. Vila   +10 more
doaj   +2 more sources

Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria

Scientific Reports, 2017
NDM-1 and its variants are the most prevalent types of metallo-β-lactamases, hydrolyze almost all antibiotics of β-lactam group leading to multiple-drug resistance in bacteria.
Asad U. Khan, Abid Ali, Danishuddin, Gaurava Srivastava, Ashok Sharma   +4 more
doaj   +2 more sources

A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases.

PLoS ONE, 2019
The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their ...
Nazmul H Khan, Anthony A Bui, Yang Xiao, R Bryan Sutton, Robert W Shaw, Benjamin J Wylie, Michael P Latham   +6 more
doaj   +2 more sources

Deciphering the evolution of metallo-β-lactamases: A journey from the test tube to the bacterial periplasm. [PDF]

J Biol Chem, 2022
Understanding the evolution of metallo-β-lactamases (MBLs) is fundamental to deciphering the mechanistic basis of resistance to carbapenems in pathogenic and opportunistic bacteria.
López C, Delmonti J, Bonomo RA, Vila AJ.   +3 more
europepmc   +2 more sources