Results 31 to 40 of about 729,044 (285)

Higher Prevalence of PldA, a Pseudomonas aeruginosa Trans-Kingdom H2-Type VI Secretion System Effector, in Clinical Isolates Responsible for Acute Infections and in Multidrug Resistant Strains

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa can manipulate eukaryotic host cells using secreted effectors delivered by the type III or the type VI Secretion Systems (T3SS and T6SS). The T3SS allows the injection of bacterial effectors (Exo toxins) into eukaryotic cell.
Thibaud Boulant, Yves-Marie Boudehen, Alain Filloux, Patrick Plesiat, Thierry Naas, Thierry Naas, Thierry Naas, Laurent Dortet, Laurent Dortet, Laurent Dortet, Laurent Dortet   +10 more
doaj   +1 more source

Transcriptional Landscape of a blaKPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10

Frontiers in Microbiology, 2018
The diffusion of KPC-2 carbapenemase is closely related to the spread of Klebsiella pneumoniae of the clonal-group 258 and linked to IncFIIK plasmids. Little is known about the biology of multi-drug resistant plasmids and the reasons of their successful ...
Agnès B. Jousset, Agnès B. Jousset, Agnès B. Jousset, Agnès B. Jousset, Isabelle Rosinski-Chupin, Isabelle Rosinski-Chupin, Julie Takissian, Julie Takissian, Philippe Glaser, Philippe Glaser, Rémy A. Bonnin, Rémy A. Bonnin, Rémy A. Bonnin, Thierry Naas, Thierry Naas, Thierry Naas, Thierry Naas   +16 more
doaj   +1 more source

Phenotypic and Molecular Detection of Extended Spectrum Beta-Lactamases Producing-Bacteria Isolated From Pregnant Women With Genital Tract Infection in Duhok Governorate

Science Journal of University of Zakho, 2021
Beta-lactamase producing bacteria have a worldwide distribution with a high degree of prevalence in both community and hospital. Furthermore, multidrug resistant (MDR) and extended spectrum β-lactamases (ESBL) producing bacterial isolates from women ...
Sozan M. Nerway, Muna S. Al-Delaimi
doaj   +1 more source

Mutation of serine residue 318 in the class C β-lactamase ofEnterobacter cloacae908R [PDF]

FEMS Microbiology Letters, 1992
The involvement of the serine residue 318 in the specificity of a class C β-lactamase was investigated. Multiple site-directed mutants at this position were generated using a polymerase chain reaction technique. These mutants were then probed for their activity towards various β-lactam compounds.
Christine Jacobs, Alain Dubus, Didier Monnaie, Staffan Normark, Jean-Marie Frère   +4 more
openaire   +1 more source

Isolation and preliminary characterization of β-lactamase excretory mutants ofEscherichia coliK-12 [PDF]

FEMS Microbiology Letters, 1984
Abstract Escherichia coli exc mutants able to release the plasmid pBR322-encoded β-lactamase (EC 3.5.2.6) into the extracellular medium have been isolated using a new in situ plate assay. A preliminary characterization of the exc mutants was carried out: the presence of exc mutations was associated with a specific or pleiotropic pattern of ...
Nicole Fognini-Lefebvre, Raymond Portalier   +1 more
openaire   +1 more source

β-Lactamase is encoded on plasmid pACK3 inStaphylococcus simulansbiovarstaphylolyticus [PDF]

FEMS Microbiology Letters, 1991
Abstract Staphylococcus simulans biovar staphylolyticus , the lysostaphin-producing organism, contains five plasmids designated pACK1 through pACK5. Hybridization analysis using cloned β-lactamase gene ( bla ) as probe and characterization of cured strains revealed that bla resides on pACK3 rather than on the lysostaphin endopeptidase plasmid ...
Harry E. Heath, Lucie S. Heath, Karen E. Rose, Gary L. Sloan   +3 more
openaire   +1 more source

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

mBio, 2019
Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as ...
Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo   +16 more
doaj   +1 more source

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

, 2019
The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1 and ...
Philip Hinchliffe (1483897), Karina Calvopiña (4923838), Pauline A. Lang (7314608), Tharindi D. Panduwawala (7388438), Jos J. A. G. Kamps (6436754), Jürgen Brem (1300083), Jonathan M. Tyrrell (7388441), James Spencer (554121), Christopher J. Schofield (233097), Alen Krajnc (7388435), Emma Widlake (7388444), Benjamin G. Saward (7388447), Timothy R. Walsh (5217941)   +12 more
core   +2 more sources

β-lactamases (bla TEM, bla SHV, bla CTXM-1, bla VEB, bla OXA-1) and class C β-lactamases gene frequency in Pseudomonas aeruginosa isolated from various clinical specimens in Khartoum State, Sudan: a cross sectional study [version 2; peer review: 2 approved]

F1000Research, 2020
Background: Pseudomonas aeruginosa is a pathogenic bacterium, causing nosocomial infections with intrinsic and acquired resistance mechanisms to a large group of antibiotics, including β-lactams.
Dina N. Abdelrahman, Aya A. Taha, Mazar M. Dafaallah, Alaa Abdelgafoor Mohammed, Abdel Rahim M. El Hussein, Ahmed I. Hashim, Yousif F. Hamedelnil, Hisham N. Altayb   +7 more
doaj   +1 more source

SUSCEPTIBILITY AND DETECTION OF EXTENDED SPECTRUM β-LACTAMASE ENZYMES FROM OTITIS MEDIA PATHOGENS [PDF]

American Journal of Infectious Diseases, 2013
Otitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults.
openaire   +1 more source