Results 31 to 40 of about 62,950 (317)
β-Lactamase is encoded on plasmid pACK3 inStaphylococcus simulansbiovarstaphylolyticus [PDF]
FEMS Microbiology Letters, 1991 Abstract Staphylococcus simulans biovar staphylolyticus , the lysostaphin-producing organism, contains five plasmids designated pACK1 through pACK5. Hybridization analysis using cloned β-lactamase gene ( bla ) as probe and characterization of cured strains revealed that bla resides on pACK3 rather than on the lysostaphin endopeptidase plasmid ...
Harry E. Heath +3 more
openaire +1 more source
Antibiotics, 2014 The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae.
Nuno T. Antunes, Jed F. Fisher
doaj +1 more source
A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]
, 2014 peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D. +4 more
core +1 more source
SUSCEPTIBILITY AND DETECTION OF EXTENDED SPECTRUM β-LACTAMASE ENZYMES FROM OTITIS MEDIA PATHOGENS [PDF]
American Journal of Infectious Diseases, 2013 Otitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults.
openaire +1 more source
mBio, 2019 Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as ...
Melissa D. Barnes +16 more
doaj +1 more source
Imipenem resistance in clinical Escherichia coli from Qom, Iran [PDF]
, 2018 OBJECTIVE: The emergence of metallo-\u3b2-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and ...
Esmkhani, M. +5 more
core +1 more source
Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria
Memorias do Instituto Oswaldo Cruz, 2018 β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was
Melise Chaves Silveira +2 more
doaj +1 more source
F1000Research, 2020 Background: Pseudomonas aeruginosa is a pathogenic bacterium, causing nosocomial infections with intrinsic and acquired resistance mechanisms to a large group of antibiotics, including β-lactams.
Dina N. Abdelrahman +7 more
doaj +1 more source
Mutation of serine residue 318 in the class C β-lactamase ofEnterobacter cloacae908R [PDF]
FEMS Microbiology Letters, 1992 The involvement of the serine residue 318 in the specificity of a class C β-lactamase was investigated. Multiple site-directed mutants at this position were generated using a polymerase chain reaction technique. These mutants were then probed for their activity towards various β-lactam compounds.
Christine Jacobs +4 more
openaire +1 more source
Could β-Lactam Antibiotics Block Humoral Immunity?
Frontiers in Immunology, 2021 It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination.
Cléa Melenotte +13 more
doaj +1 more source