Results 1 to 10 of about 45,681 (215)

The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers [PDF]

Engineering
This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum activity against ...
Zhuoren Ling, Kate Cook, Jordan Mathias   +2 more
exaly   +6 more sources

Revisiting the Checkerboard to Inform Development of β-Lactam/β-Lactamase Inhibitor Combinations [PDF]

Antibiotics
A two-dimensional “checkerboard” array employing systematic titration (e.g., serial two-fold dilutions) is a well-established in vitro method for exploring the antibacterial effects of novel drug combinations.
Darren J. Bentley
doaj   +3 more sources

New β-Lactam/β-Lactamase Inhibitor Combination Antibiotics [PDF]

Pathogens
The growing problem of infections due to pathogens with antimicrobial resistance, especially Gram-negative bacteria, has led to the development of new β-lactam/β-lactamase inhibitor combination antibiotics.
Maria Sargianou, Panagiotis Stathopoulos, Christos Vrysis, Iva D. Tzvetanova, Matthew E. Falagas   +4 more
doaj   +2 more sources

β-Lactam/β-Lactamase Inhibitor Combination Antibiotics Under Development [PDF]

Pathogens
Antimicrobial resistance remains a public health problem of global concern with a great health and financial burden. Its recognition as a threat by political leadership has boosted the research and development of new antibiotics and particularly novel ...
Angeliki Katsarou, Panagiotis Stathopoulos, Iva D. Tzvetanova, Christina-Maria Asimotou, Matthew E. Falagas   +4 more
doaj   +2 more sources

Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors

Communications Chemistry
Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics ...
Kinga Virág Gulyás, Liping Zhou, Daniel Salamonsen, Andreas Prester, Kim Bartels, Robert Bosman, Paul Haffke, Jintian Li, Viola Tamási, Fritz Deufel, Johannes Thoma, Anna Andersson Rasmussen, Miklós Csala, Hanna-Kirsti Schroder Leiros, Zhijian Xu, Mikael Widersten, Holger Rohde, Eike C. Schulz, Weiliang Zhu, Máté Erdélyi   +19 more
doaj   +6 more sources

Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes [PDF]

Microbial Cell Factories
β-lactam resistance is a significant global public health issue. Outbreaks of bacteria resistant to extended-spectrum β-lactams and carbapenems are serious health concerns that not only complicate medical care but also impact patient outcomes.
Lamiaa A. Al-Madboly, Mohamed A. Abd El-Salam, Jairo K. Bastos, Shaimaa Aboukhatwa, Rasha M. El-Morsi   +4 more
doaj   +2 more sources

Molecular Docking Approach of Viscosin as Antibacterial for Methicillin-resistant Staphylococcus Aureus Via β-Lactamase Inhibitor Mechanism

Clinical and Research Journal in Internal Medicine, 2021
Background: β-lactamase is an enzyme that plays a role in the occurrence of antibiotic resistance against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Viscosin is a lipopeptide biosurfactant produced by the Pseudomonas group bacteria.
Mokhamad Fahmi Rizki Syaban, Nabila Erina Erwan, Muhammad Rafif Raihan Syamsuddin, Fatimah Az Zahra, Faradilah Lukmana Sabila   +4 more
openaire   +1 more source

Efficacy and safety of novel carbapenem–β-lactamase inhibitor combinations: Results from phase II and III trials

Frontiers in Cellular and Infection Microbiology, 2022
ObjectivesThe addition of novel β-lactamase inhibitors to carbapenems restores the activity against multidrug-resistant Gram-negative bacteria. The aim of this study was to summarize the evidence on the efficacy and safety of novel carbapenem–β-lactamase
Wei Yu, Ping Shen, Qixia Luo, Luying Xiong, Yonghong Xiao   +4 more
doaj   +1 more source

Penetration of β-lactamase inhibitors into the periplasm of Gram-negative bacteria [PDF]

FEMS Microbiology Letters, 1999
The effectiveness of a beta-lactamase inhibitor/beta-lactam combination against Gram-negative pathogens depends on many interplaying factors, one of which is the penetration of the inhibitor across the outer membrane. In this work we have measured the relative penetrations of clavulanic acid, sulbactam, tazobactam and BRL 42715 into two strains of ...
Farmer TH, Degnan BA, Payne DJ
openaire   +3 more sources

Outer membrane permeability of β-lactamase inhibitors inPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1995
Evaluation of four beta-lactamase inhibitors in terms of their outer membrane permeability in Pseudomonas aeruginosa revealed that sulbactam and tazobactam diffused most efficiently and equally well. That of BRL42715 appeared to be a factor of ten lower than that of the above two, but it showed the strongest beta-lactamase inhibitory activity.
S, Satake, T, Nakae
openaire   +2 more sources