Results 41 to 50 of about 1,489,579 (226)

Smart Antibacterial Coatings: Harnessing Bacterial Redox Activity for Infection Control

Advanced Materials Interfaces, EarlyView.
In this study, we have shown that ceftazidime‐loaded poly(3,4‐ethylenedioxythiophene) (PEDOT@CAZ) functions as a smart, redox‐responsive antibacterial coating that couples bacterial electrical activity with localized antibiotic delivery. Shewanella oneidensis and Pseudomonas aeruginosa induced distinct redox responses in PEDOT, reflecting their ...
Abdullah, Szymon Smołka, Kamran Ayaz, Sara Shakibania, Sajida Maryam, Taral Patel, Roman Turczyn, Ewa Zabłocka‐Godlewska, Katarzyna Krukiewicz   +8 more
wiley   +1 more source

Characterization of BAS-1, a novel class A β-lactamase encoded in Bacteroides thetaiotaomicron

Antimicrobial Agents and Chemotherapy
We characterized a novel class A β-lactamase (BAS-1) in a pan-β-lactam-resistant Bacteroides thetaiotaomicron clinical isolate. Whole-genome sequencing identified blaBAS-1 within a mobile genetic element associated with IS4351.
María Aznar Fernández, María José Gómez Gómez, José Miguel Cisneros, José Antonio Lepe, José Manuel Ortiz de la Rosa   +4 more
doaj   +1 more source

DeepBLI: A Transferable Multichannel Model for Detecting β‑Lactamase-Inhibitor Interaction

, 2022
Pathogens producing β-lactamase pose a great challenge to antibiotic-resistant infection treatment; thus, it is urgent to discover novel β-lactamase inhibitors for drug development.
Ruihan Dong (13967434), Chengwei Ai (13967437), Fei Guo (181055), Hongpeng Yang (13550298), Jianxin Wang (35827), Guihua Duan (2029471)   +5 more
core   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

A Novel β-lactam/β-lactamase Inhibitor: Ceftolozane/tazobactam

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2019
Ceftolozane/tazobactam is a novel generation cephalosporin and β-lactamase inhibitor combination antibiotic. It was approved for the treatment of adults (18 years and older) with complicated intraabdominal infections used in combination with ...
Kıvanç ŞEREFHANOĞLU
doaj   +1 more source

Expression of ESBL, MBL and AmpC β lactamases by extra intestinal Escherichia coli isolates: correlation with treatment and clinical outcome [PDF]

Journal of Microbiology and Infectious Diseases, 2013
Objective:We investigated the expression of Extended Spectrum β-Lactamases (ESBLs), AmpC β lactamases and Carbapenemases in extraintestinal pathogenic Escherichia coli (ExPEC) isolates and correlated with treatment and outcome of the patients. Methods:
Arindam Chakraborty , Prabha Adhikari , Shalini Shenoy , Shrikala Baliga , Satish Rao , Dhanashree Biranthabail , Vishwas Saralaya   +6 more
doaj   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Sequential Molecular Docking Analysis of Amoxicillin–Clavulanic Acid Interaction with TEM-1 β-Lactamase

Trends in Pharmacy
Background: β-lactamase-mediated degradation of β-lactam antibiotics is a major contributor to antimicrobial resistance. Amoxicillin, a widely used β-lactam antibiotic, is particularly susceptible to hydrolysis by Temoniera-1 (TEM-1) β-lactamase ...
Nepolean R, Ramesh K
doaj   +3 more sources

Biochemical characterization of CTX-M-15 from Enterobacter cloacae and designing a novel non-β-lactam-β-lactamase inhibitor. [PDF]

PLoS ONE, 2013
The worldwide dissemination of CTX-M type β-lactamases is a threat to human health. Previously, we have reported the spread of bla(CTX-M-15) gene in different clinical strains of Enterobacteriaceae from the hospital settings of Aligarh in north India. In
Mohammad Faheem, Md Tabish Rehman, Mohd Danishuddin, Asad U Khan   +3 more
doaj   +1 more source