Results 41 to 50 of about 45,681 (215)

Distribution of β-lactamase genes of Klebsiella pneumoniae isolates in Zhejiang province, China, and regulation of gene expression [PDF]

Archives of Biological Sciences, 2017
Klebsiella pneumoniae is a common causative agent of nosocomial infections with a high level of resistance toward β-lactam antibiotics. Our previous study showed that TEM-1 and SHV-11 are the predominant β-lactamase-encoding genes of K ...
Zhao Jin-Fang, Wang Qiang, Ge Yu-Mei, Tan Pan-Li, Chen Yi-Min, Yan Jie   +5 more
doaj   +1 more source

Escherichia coli of sequence type 3835 carrying blaNDM-1, blaCTX-M-15, blaCMY-42 and blaSHV-12

, 2015
New Delhi metallo-β-lactamase (NDM) represents a serious challenge for treatment and public health. A carbapenem-resistant Escherichia coli clinical strain WCHEC13-8 was subjected to antimicrobial susceptibility tests, whole genome sequencing and ...
Wang, X, Zong, Z, Yang, Ping, Xie, Y, Zong, Zhiyong, Feng, Yu, Yang, P, Feng, Y, McNally, A, Wang, Xiaohui, McNally, Alan; id_orcid, Xie, Yi   +11 more
core   +1 more source

In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations

Microbiology Spectrum
Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats and have few approved therapeutic options. Non-‍fermenting Gram-negative isolates were collected from hospitalized inpatients from 49 sites in 6 European countries
Anne Santerre Henriksen, Katy Jeannot, Antonio Oliver, John D. Perry, Mathias W. Pletz, Stefania Stefani, Ian Morrissey, Christopher Longshaw   +7 more
doaj   +1 more source

Label-Free Photonic Crystal-Based β‑Lactamase Biosensor for β‑Lactam Antibiotic and β‑Lactamase Inhibitor

, 2016
A simple, label-free, and visual photonic crystal-based β-lactamase biosensor was developed for β-lactam antibiotic and β-lactamase inhibitor in which the penicillinase (a β-lactamase) was immobilized on the pH-sensitive colloidal crystal hydrogel (CCH ...
Qianshan Chen (3090420), Ruqin Yu (1336647), Guoguo Li (3090426), Yan Wu (70890), Zhaoyang Wu (334049), Fubing Xiao (3090423)   +5 more
core   +1 more source

Expression of ESBL, MBL and AmpC β lactamases by extra intestinal Escherichia coli isolates: correlation with treatment and clinical outcome [PDF]

Journal of Microbiology and Infectious Diseases, 2013
Objective:We investigated the expression of Extended Spectrum β-Lactamases (ESBLs), AmpC β lactamases and Carbapenemases in extraintestinal pathogenic Escherichia coli (ExPEC) isolates and correlated with treatment and outcome of the patients. Methods:
Arindam Chakraborty , Prabha Adhikari , Shalini Shenoy , Shrikala Baliga , Satish Rao , Dhanashree Biranthabail , Vishwas Saralaya   +6 more
doaj   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Clinical role of β-lactam/β-lactamase inhibitor combinations

, 2003
The use of β-lactamase inhibitors in combination with β-lactam antibiotics is currently the most successful strategy to combat a specific resistance mechanism.
Lee, N, Kumana, CR, Yuen, KY
core   +1 more source

The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Antimicrobial Resistance and Infection Control, 2018
Treating M. abscessus infection is challenging due to the potent β-lactamase BlaMab (Beta-lactamase of M. abscessus ). Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit BlaMab.
Michal Meir, Pablo Bifani, Daniel Barkan
doaj   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

β-lactam/β-lactamase inhibitor combinations: an update

, 2018
Antibiotic resistance caused by β-lactamase production continues to present a growing challenge to the efficacy of β-lactams and their role as the most important class of clinically used antibiotics.
Martin, N.I., Tehrani, K.H.M.E.
core   +1 more source