Results 61 to 70 of about 1,489,579 (226)
mBio, 2018 Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics.
Melissa D. Barnes +11 more
doaj +1 more source
Antibiotics, 2023 Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy +17 more
doaj +1 more source
Optimization of β-Lactam/β-Lactamase Inhibitor Dosing
, 2020 Infections caused by extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria are associated with increased mortality and cost of care.
Abodakpi, Henrietta Dzigbordi
core
N-Nitroso-β-lactams as β-lactamase inhibitor [PDF]
, 1989 N-Nitroso-β-phenyl-β-lactam has been found to be a specific inhibitor of β-lactamase. N-Nitroso-α-phenyl-β-lactam, by contrast, was virtually ineffective although a transient inhibition of short duration was observed.
Tanizawa, Kazutaka +5 more
core +1 more source
Food Safety and Health, EarlyView.This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento +13 more
wiley +1 more source
Optimization of β-Lactam/β-Lactamase Inhibitor Dosing
, 2018 Infections caused by extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacteria are associated with increased mortality and cost of care.
Abodakpi, Henrietta Dzigbordi
core +1 more source
PLoS ONE, 2014 Bacterial resistance is a serious threat to human health. The production of β-lactamase, which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics.
Mohd Hassan Baig +7 more
doaj +1 more source
Sulbactam-containing β-lactamase inhibitor combinations [PDF]
, 2008 Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against β-lactamase-producing
Sierra Valverde, Álvaro Javier +1 more
core +1 more source
The Preparation of Novel Fluorenes Inspired by Hipposudoric Acid
Helvetica Chimica Acta, EarlyView.In this research we report on the design and synthesis of a series of fluorene‐based derivatives loosely inspired by the tricyclic framework of hipposudoric acid. Preparation of sixteen novel N‐alkylated derivatives was accomplished via a series of concise one‐step amide N‐alkylation reactions.
Munib Uddin +3 more
wiley +1 more source
四川大学学报. 自然科学版, 2017 Carbapenems, used in clinical treatment of multi-drug resistance bacterial infection, can be hydrolyzed by Klebsiella pneumoniae carbapenemases, which weaken the treatment effect of gram negative bacterial infection.
ZUO Ke +5 more
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