Results 61 to 70 of about 33,392 (201)

Biotechnological applications of functional metagenomics in the food and pharmaceutical industries [PDF]

, 2015
peer-reviewedMicroorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods.
Alvarez-Ordonez, Avelino, Cotter, Paul D., Coughlan, Laura M., Hill, Colin   +3 more
core   +1 more source

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, EarlyView.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Genetic Analysis of Virulence and β-Lactamase Determinants Related to β-Lactamase Inhibitors in Pseudomonas aeruginosa Strains from Nosocomial Infections

Antibiotics
Background/Objectives: The emergence of hypervirulent Pseudomonas aeruginosa strains resistant to β-lactamase inhibitor antibiotics is a critical health problem as they impede the treatment of infections.
Gloria Luz Paniagua-Contreras, Elizabeth Olvera-Navarro, Jennefer Paloma Herrera-Gabriel, Laura Verónica González-Vega, Luis Rey García-Cortés, Moisés Moreno-Noguez, Héctor Martínez-Gregorio, Felipe Vaca-Paniagua, Ana María Fernández-Presas, Eric Monroy-Pérez   +9 more
doaj   +1 more source

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa

mBio, 2018
Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics.
Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo   +11 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

A Novel β-lactam/β-lactamase Inhibitor: Ceftolozane/tazobactam

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2019
Ceftolozane/tazobactam is a novel generation cephalosporin and β-lactamase inhibitor combination antibiotic. It was approved for the treatment of adults (18 years and older) with complicated intraabdominal infections used in combination with ...
Kıvanç ŞEREFHANOĞLU
doaj   +1 more source

Determination of MIC and Disk Diffusion Quality Control Guidelines for Meropenem–Vaborbactam, a Novel Carbapenem/Boronic Acid β-Lactamase Inhibitor Combination [PDF]

, 2018
Meropenem–vaborbactam is a carbapenem/cyclic boronic acid β-lactamase inhibitor combination primarily active against Gram-negative bacilli, including those harboring class A serine carbapenemases such as Klebsiella pneumoniae carbapenemase (KPC).
Castanheira, Mariana, Fedler, Kelley A., Flamm, Robert K., Huband, Michael D., Munson, Erik   +4 more
core   +1 more source

Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri [PDF]

, 2015
Metallo-β-lactamases (MBLs) hydrolyze almost all classes of β-lactam antibiotic, including carbapenems—currently first choice drugs for opportunistic infections by Gram-negative bacterial pathogens.
Booth, Michael P. S., Kosmopoulou, Magda, Nordmann, Patrice, Poirel, Laurent, Spencer, James   +4 more
core   +2 more sources

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Insight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics study.

PLoS ONE, 2014
Bacterial resistance is a serious threat to human health. The production of β-lactamase, which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics.
Mohd Hassan Baig, D Raja Sudhakar, Ponnusamy Kalaiarasan, Naidu Subbarao, Gulshan Wadhawa, Mohtashim Lohani, M Kalim A Khan, Asad U Khan   +7 more
doaj   +1 more source