Results 51 to 60 of about 33,392 (201)

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Cephalosporin-3’-diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of non-typeable Haemophilus influenzae biofilms [PDF]

, 2016
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Objectives: PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO)-donor prodrug designed to ...
Allan, Raymond N., Coles, J., Collins, S. A., Connett, G., Faust, S. N., Feelisch, M., Hall-Stoodley, L., Halladay, G. D., Jackson, C. L., Kelso, M. J., Lucas, J. S. A., Rineh, A., Walker, W. T., Webb, J. S., Yepuri, N. R.   +14 more
core   +6 more sources

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +4 more sources

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Isolasi Dan Karakterisasi Bakteri Penghasil Antibiotik Inhibitor Β -Laktamasetipe Tem-1 Dari Ekosistem Air Hitam Kalimantan Tengah [PDF]

, 2008
Β-lactamase inhibitor antibiotic is highly required to prevent the increasing of bacterial resistance towards β lactam antibiotics. This study was aimed to isolate and characterize of bacteria producing TEM-1 β lactamase inhibitor antibiotic.
Liswara, N. (Neneng)
core  

Conformational Changes in the Metallo-β-lactamase ImiS During the Catalytic Reaction: An EPR Spectrokinetic Study of Co(II)-Spin Label Interactions [PDF]

, 2008
Metallo-β-lactamases are responsible for conferring antibiotic resistance on certain pathogenic bacteria. In consequence, the search for inhibitors that may be useful in combating antibiotic resistance has fueled much study of the active sites of these ...
Bennett, Brian, Crowder, Michael W., Hu, Zhenxin, Sharma, Narayan   +3 more
core   +2 more sources

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

EBioMedicine, 2016
Mycobacterium tuberculosis (M. tuberculosis) is considered innately resistant to β-lactam antibiotics. However, there is evidence that susceptibility to β-lactam antibiotics in combination with β–lactamase inhibitors is variable among clinical isolates ...
Keira A. Cohen, Tal El-Hay, Kelly L. Wyres, Omer Weissbrod, Vanisha Munsamy, Chen Yanover, Ranit Aharonov, Oded Shaham, Thomas C. Conway, Yaara Goldschmidt, William R. Bishai, Alexander S. Pym   +11 more
doaj   +1 more source

Repurposing of Meropenem and Nadifloxacin for Treatment of Burn Patients? [PDF]

, 2009
The escalating number of multidrug resistant pathogens has demanded the swift development of new and potent antibiotics (ref. 2). Metallo-[beta]-lactamases (MBLs) continue to evolve, rendering the latest generation of carbapenem antibiotics useless (ref.
Christie E. Costa, James Spencer, Janice D. Thomas, Jeffrey H. Toney, Joseph G. Moloughney, Karla S. Bullon   +5 more
core   +1 more source