Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species [PDF]
Antimicrobial Resistance and Infection Control, 2016 Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
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Sulbactam: A β–Lactam Compound with Neuroprotective Effects in Epilepsy [PDF]
Neurology InternationalBackground: The pathophysiology of epilepsy is characterized by increased neuronal activity due to an excess of the excitatory neurotransmitter glutamate and a deficiency in the inhibitory neurotransmitter gamma–aminobutyric acid (GABA).
Fang-Chia Chang +8 more
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Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus [PDF]
Acta Pharmaceutica Sinica B, 2019 Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus (MRSA). Thus, there is an urgent need to develop novel approaches to successfully treat this infection.
Genzhu Wang +8 more
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Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon? [PDF]
AntibioticsPseudomonas aeruginosa is a significant threat to public health as an aggressive, opportunistic pathogen. The use of β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems remains a front-line treatment against P ...
Dylan W. Zhao, Christopher T. Lohans
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Unraveling the mechanisms behind the enhanced efficacy of β-lactam-based sideromycins [PDF]
Communications BiologyPrevious studies have explored combining β-lactams with siderophores to create Trojan horse molecules that can penetrate the outer membrane of Gram-negative bacteria via TonB-dependent transporter (TBDT).
Evelyne Lacasse +8 more
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Frontiers in Microbiology, 2023 β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar +4 more
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Critical Care Explorations, 2022 OBJECTIVE:. β-lactams are the cornerstone of empiric and targeted antibiotic therapy for critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug monitoring (TDM) within 24–48 hours after the initiation of therapy in ...
Thomas J. Dilworth, PharmD +4 more
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1,4-diacetoxy-β-lactams. Reactions with nucleophiles [PDF]
, 1985 β-Lactam reacts with hetero nucleophiles under ring cleavage to give 2,2-dimethyl-3-oximinobutanoic esters 6 and 7 .
Elburg, P.A. van +3 more
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The state and consideration for skin test of β-lactam antibiotics in pediatrics
Frontiers in Cellular and Infection Microbiology, 2023 β-lactam antibiotics are the most frequently used drugs and the most common drugs that cause allergic reactions in pediatrics. The occurrence of some allergic reactions can be predicted by skin testing, especially severe adverse reactions such as ...
Chunhui Gao +3 more
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Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]
, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael +8 more
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