An Achilles' heel for methicillin-resistant Staphylococcus aureus? Re-evaluating β-lactam susceptibility of MRSA [PDF]
Antimicrobial Agents and ChemotherapyMethicillin-resistant Staphylococcus aureus (MRSA) infections (i.e., carrying the mec gene) are challenging to treat due to their inherent resistance to most antistaphylococcal β-lactams.
Neta Petersiel +3 more
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Evaluation of drug-drug interaction between nacubactam and β-lactam antibiotic (cefepime, aztreonam, meropenem, or piperacillin) in Japanese healthy participants [PDF]
Antimicrobial Agents and ChemotherapyWe conducted an open-label study to assess the pharmacokinetics, safety, and tolerability of nacubactam—a β-lactamase inhibitor—administered alone or in combination with β-lactam antibiotic.
Jun Morita +7 more
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Regulation of PBP2x Surface Localization by aliD and clpL Alters β-Lactam Resistance in Pneumococcus [PDF]
PathogensStreptococcus pneumoniae is a leading cause of respiratory infections and is often treated with β-lactam antibiotics despite frequent resistance. The β-lactam resistance is through mutations in penicillin-binding proteins (PBPs), but the impact of PBP ...
Lucas R. G. Crosby +3 more
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Sulbactam: A β–Lactam Compound with Neuroprotective Effects in Epilepsy [PDF]
Neurology InternationalBackground: The pathophysiology of epilepsy is characterized by increased neuronal activity due to an excess of the excitatory neurotransmitter glutamate and a deficiency in the inhibitory neurotransmitter gamma–aminobutyric acid (GABA).
Fang-Chia Chang +8 more
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β-Lactam Antibiotics Renaissance
Antibiotics, 2014 Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective.
Wenling Qin
exaly +3 more sources
Frontiers in Microbiology, 2023 β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar +4 more
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Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]
FEMS Microbiology Letters, 1995 A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky +3 more
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Critical Care Explorations, 2022 OBJECTIVE:. β-lactams are the cornerstone of empiric and targeted antibiotic therapy for critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug monitoring (TDM) within 24–48 hours after the initiation of therapy in ...
Thomas J. Dilworth, PharmD +4 more
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A method to transform the β-lactam antibiotic producerStreptomyces wadayamensis [PDF]
FEMS Microbiology Letters, 1986 We have developed a transformation system for Streptomyces wadayamensis, a cephamycin C producer. 1−5 × 109 protoplasts can be obtained when late logarithmic phase cultures of this microorganisms are incubated with 10 mg/ml of lysozyme. Polyethylene glycol-Ca2+-mediated transformation of these protoplasts yielded 106 transformants per μg of pIJ702 or ...
C. Acebal, V. Rubio, G. Márquez
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Stereoselective cyanation of 4-formyl and 4-imino-?-lactams: application to the synthesis of polyfunctionalized ?-lactams [PDF]
Tetrahedron, 2012 Peer ...
Alcaide, Benito +3 more
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