mBio, 2023 The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility ...
Aaron C. Nolan +7 more
doaj +1 more source
Restoration of effectiveness of β-lactams on methicillin-resistantStaphylococcus aureusby tellimagrandin I from rose red [PDF]
FEMS Microbiology Letters, 2000 We found that extract from petals of Rosa canina L. (rose red) strikingly reduced the minimum inhibitory concentration of beta-lactams in methicillin-resistant Staphylococcus aureus. We isolated two compounds that reduced the minimum inhibitory concentrations of beta-lactams from the extract, tellimagrandin I and rugosin B.
S, Shiota +6 more
openaire +2 more sources
Thefiblocus inStreptococcus pneumoniaeis required for peptidoglycan crosslinking and PBP-mediated β-lactam resistance [PDF]
FEMS Microbiology Letters, 2000 Penicillin resistance in pneumococci is mediated by modified penicillin-binding proteins (PBPs) that have decreased affinity to beta-lactams. In high-level penicillin-resistant transformants of the laboratory strain Streptococcus pneumoniae R6 containing various combinations of low-affinity PBPs, disruption of the fib locus results in a collapse of PBP-
B, Weber +5 more
openaire +2 more sources
Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones [PDF]
, 2018 Because of the beneficial effect of a trifluoromethyl group on the biological properties of bioactive compounds on the one hand and the versatile synthetic potential of beta-lactams on the other hand, 4-CF3-beta-lactams comprises interesting entities for
D'hooghe, Matthias +2 more
core +1 more source
Decreased membrane permeability in a polymyxin B-resistantEscherichia colimutant exhibiting multiple resistance to β-lactams as well as aminoglycosides [PDF]
FEMS Microbiology Letters, 1998 A laboratory mutant of Escherichia coli stably resistant to more than 36,000 U ml-1 of polymyxin B was isolated. The mutant exhibited moderate increases in minimum inhibitory concentration to fluoroquinolones and bacitracin but high levels of cross-resistance to beta-lactams and aminoglycosides.
S O, Rahaman +3 more
openaire +2 more sources
Journal of Immunology Research, 2022 Introduction. The risk of extended spectrum β-lactamase (ESBL) bacterial acquisition in patients with β-lactam allergy has been poorly investigated. In a previous study conducted over a 6-year long period (2007-2012), we found that patients with declared
Alessio Strazzulla +9 more
doaj +1 more source
Antibiotic residues and antibiotic-resistant bacteria in pig slurry used to fertilize agricultural fields [PDF]
, 2020 Pig manure may contain antibiotic residues, antibiotic-resistant bacteria or pathogens, which may reach the environment upon fertilization. During this study, 69 antibiotic residues belonging to 12 classes were quantified in 89 pig slurry samples.
Colson, Lander +9 more
core +2 more sources
Gold-catalyzed bis-cyclization of 1,2-diol- or acetonide-tethered alkynes. Synthesis of ?-lactam-bridged acetals: a combined experimental and theoretical study [PDF]
Tetrahedron, 2012 Peer ...
Alcaide, Benito +4 more
openaire +2 more sources
Transcriptome analysis of the two unrelated fungal β-lactam producers Acremonium chrysogenum and Penicillium chrysogenum: Velvet-regulated genes are major targets during conventional strain improvement programs [PDF]
, 2017 Background Cephalosporins and penicillins are the most frequently used β-lactam antibiotics for the treatment of human infections worldwide. The main industrial producers of these antibiotics are Acremonium chrysogenum and Penicillium chrysogenum, two ...
Dominik Terfehr +2 more
core +1 more source
β-Lactam induction of ISEcp1B-mediated mobilization of the naturally occurringblaCTX-Mβ-lactamase gene ofKluyvera ascorbata [PDF]
FEMS Microbiology Letters, 2008 ISEcp1B is an insertion element associated with the emerging expanded-spectrum beta-lactamase bla(CTX-M) genes in Enterobacteriaceae. Because ISEcp1B-bla(CTX-M)positive strains may be identified from humans and animals, the ability of this insertion sequence to mobilize the bla(CTX-M-2) gene was tested from its progenitor Kluyvera ascorbata to study ...
Nordmann, Patrice +2 more
openaire +3 more sources