Results 21 to 30 of about 764,478 (294)

Antibiotic Resistance in Pseudomonas Aeruginosa is Associated with Decreased Fitness

Cellular Physiology and Biochemistry, 2013
The number of clinical specimens containing β-lactam-resistant Pseudomonas aeruginosa isolates is increasing. However, whether resistance is associated with reduced fitness is still uncertain in clinical Pseudomonas aeruginosa isolates. In this study, we
Zhenzhen Sun, Xiaoyang Jiao, Qing Peng, Fang Jiang, Yuanchun Huang, Juan Zhang, Fen Yao   +6 more
doaj   +1 more source

Salicylate decreases production of AmpC type β-lactamases and increases susceptibility to β-lactams in aMorganella morganiiclinical isolate [PDF]

FEMS Microbiology Letters, 2004
The effect of salicylate, a marRAB inducer, on the resistance to β-lactams was characterized in an AmpC β-lactamase hyperproducer Morganella morganii clinical isolate (the M1 strain). Results were compared with those of the effect of salicylate in a wild-type M. morganii strain.
María M. Tavío, Mariagrazia Perilli, Jordi Vila, Pino Becerro, Lucía Casañas, Gianfranco Amicosante, María Teresa Jiménez de Anta   +6 more
openaire   +1 more source

Transcending the challenge of evolving resistance mechanisms in Pseudomonas aeruginosa through β-lactam-enhancer-mechanism-based cefepime/zidebactam

mBio, 2023
Multi-drug resistant (MDR) Pseudomonas aeruginosa harbor a complex array of β-lactamases and non-enzymatic resistance mechanisms. In this study, the activity of a β-lactam/β-lactam-enhancer, cefepime/zidebactam, and novel β-lactam/β-lactamase inhibitor ...
Andrea M. Hujer, Steven H. Marshall, Andrew R. Mack, Kristine M. Hujer, Yamuna Devi Bakthavatchalam, Kushal Umarkar, Snehal R. Palwe, Swapna Takalkar, Prashant R. Joshi, Rahul Shrivastava, Hariharan Periasamy, Sachin S. Bhagwat, Mahesh V. Patel, Balaji Veeraraghavan, Robert A. Bonomo   +14 more
doaj   +1 more source

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a. [PDF]

, 2014
Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of
Taylor, Peter W, Paulin, S, Roper, David I, Garcia-Lara, J, Roper, DI, Taylor, PW, Galley, Nicola F., Paulin, Sarah, Rosado, H, Foster, SJ, Taylor, Peter W., Dafforn, TR, Dafforn, Tim, Dafforn, Timothy R, Galley, Nicola F, Jamshad, Mohammed, Rosado, Helena, Foster, Simon J, Garcia-Lara, Jorge, Jamshad, M, Galley, NF, Foster, Simon J., Roper, David I.   +22 more
core   +1 more source

Engineering and functional characterization of a proton-driven β-lactam antibiotic translocation module for bionanotechnological applications [PDF]

, 2021
Novel approaches in synthetic biology focus on the bottom-up modular assembly of natural, modified natural or artificial components into molecular systems with functionalities not found in nature.
Dimitrios Fotiadis, Harder, Daniel, Stauffer, Mirko, Fotiadis, Dimitrios, Daniel Harder, Mirko Stauffer, Zöhre Ucurum, Ucurum, Zöhre   +7 more
core   +1 more source

Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species

Antimicrobial Resistance and Infection Control, 2016
Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
doaj   +1 more source

β-Lactam induction of colanic acid gene expression inEscherichia coli [PDF]

FEMS Microbiology Letters, 2003
An unexpected observation led us to examine the relationship between beta-lactam exposure and synthesis of colonic acid capsular polysaccharide in Escherichia coli. Strains containing a cps-lacZ transcriptional fusion were challenged with antibiotics having various modes of action, and gene expression was detected by a disk-diffusion assay and in broth
Frances C, Sailer, Bernadette M, Meberg, Kevin D, Young   +2 more
openaire   +2 more sources

Synergistic Combinations of FDA-Approved Drugs with Ceftobiprole against Methicillin-Resistant Staphylococcus aureus

Microbiology Spectrum, 2023
New strategies are urgently needed to address the public health threat of antimicrobial resistance. Synergistic agent combinations provide one possible pathway toward addressing this need and are also of fundamental mechanistic interest.
Amar Deep Sharma, William G. Gutheil
doaj   +1 more source

Involvement of O8-antigen in altering β-lactam antibiotic susceptibilities inEscherichia coli [PDF]

FEMS Microbiology Letters, 2008
In spite of being dispensable, O-antigens are believed to facilitate various cellular processes and alter antibiotic sensitivities. Escherichia coli K-12 (CS109) strains are lacking in O-antigens and are reported to be sensitive to antibiotics. To our surprise, E. coli 2443 (expressing O8-antigen) manifested two- to fourfold higher sensitivities toward
Sujoy K, Sarkar, Anindya S, Ghosh
openaire   +2 more sources

FtsH Sensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics by Degrading YpfP, a Lipoteichoic Acid Synthesis Enzyme

Antibiotics, 2021
In the Gram-positive pathogen Staphylococcus aureus, FtsH, a membrane-bound metalloprotease, plays a critical role in bacterial virulence and stress resistance.
Won-Sik Yeo, Bohyun Jeong, Nimat Ullah, Majid Ali Shah, Amjad Ali, Kyeong Kyu Kim, Taeok Bae   +6 more
doaj   +1 more source