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Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon? [PDF]

Antibiotics
Pseudomonas aeruginosa is a significant threat to public health as an aggressive, opportunistic pathogen. The use of β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems remains a front-line treatment against P ...
Dylan W. Zhao, Christopher T. Lohans
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Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics [PDF]

Advanced Science
Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance.
Julia Werner, Florian Umstätter, Manuel B. Böhmann, Hannah Müller, Barbro Beijer, Tobias Hertlein, Laura Kaschnitz, Veronika Bram, Christian Kleist, Karel D. Klika, Eric Mühlberg, Gabriel Braune, Sabrina Wohlfart, Martin Gärtner, Silke Peter, Stefan Zimmermann, Uwe Haberkorn, Knut Ohlsen, Heike Brötz‐Oesterhelt, Walter Mier, Philipp Uhl   +20 more
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Effect of β-lactam antibiotics on the gut microbiota of term neonates [PDF]

Annals of Clinical Microbiology and Antimicrobials
β-Lactam antibiotics are a class of antibiotics commonly used to treat bacterial infections. However, the effects of β-lactam antibiotics on term neonatal intestinal flora have not been fully elucidated. Hospitalized full-term newborns receiving β-lactam
Hongdan Gu, Enfu Tao, Yijia Fan, Gao Long, Xinyi Jia, Tianming Yuan, Lihua Chen, Xiaoli Shu, Wei Zheng, Mizu Jiang   +9 more
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Novel β-lactam antibiotics versus other antibiotics for treatment of complicated urinary tract infections: a systematic review and meta-analysis [PDF]

Frontiers in Pharmacology
BackgroundNovel β-lactam antibiotics as well as other kinds of antibiotics have been used to treat complicated urinary tract infections (cUTIs); however, their efficacy and safety remain controversial.ObjectiveWe conducted a systematic review with meta ...
Xiang hua Quan, Xin yi Wang, Chun hua Han, Xiao min Xing, Bin Zhang, Huai qin Cang   +5 more
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The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics [PDF]

Antibiotics
Background: Therapeutic strategies for methicillin-resistant Staphylococcus aureus (MRSA) are increasingly limited due to the ability of the pathogen to evade conventional treatments such as vancomycin and daptomycin. This challenge has shifted the focus
Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti   +5 more
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Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics [PDF]

Frontiers in Pharmacology
The β-Lactam antibiotics represent a widely used class of antibiotics, yet the latent and often overlooked risk of coagulation dysfunction associated with their use underscores the need for proactive assessment.
Yuqing Hua, Yuqing Hua, Na Li, Jiahui Lao, Zhaoyang Chen, Shiyu Ma, Xiao Li   +6 more
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β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment [PDF]

Frontiers in Microbiology
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating their mechanisms of action and developing more effective therapeutic strategies.
Dongyang Ye, Dongyang Ye, Dongyang Ye, Jing Sun, Jing Sun, Ran Jiang, Jiashen Chang, Yiming Liu, Xiangzheng Wu, Luqi Li, Yihan Luo, Juan Wang, Juan Wang, Juan Wang, Kangkang Guo, Kangkang Guo, Kangkang Guo, Zengqi Yang, Zengqi Yang, Zengqi Yang   +19 more
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Mutations in ampD cause hyperproduction of AmpC and CmcB β-lactamases and high resistance to β-lactam antibiotics in Chromobacterium violaceum [PDF]

Microbiology Spectrum
Bacterial resistance to β-lactam antibiotics mediated by β-lactamase enzymes is widespread worldwide. Chromobacterium violaceum, an environmental Gram-negative bacterial pathogen, is intrinsically resistant to some β-lactam antibiotics.
Luís Gustavo Laranjeiro, Carlos Eduardo M. Neme, Maristela Previato-Mello, Bianca B. Batista, Isabel Henriques, José F. da Silva Neto   +5 more
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β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

Frontiers in Microbiology, 2023
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar, Medha Chakraborty, Shashi Kumari, Deepjyoti Paul, Bhabatosh Das   +4 more
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The state and consideration for skin test of β-lactam antibiotics in pediatrics

Frontiers in Cellular and Infection Microbiology, 2023
β-lactam antibiotics are the most frequently used drugs and the most common drugs that cause allergic reactions in pediatrics. The occurrence of some allergic reactions can be predicted by skin testing, especially severe adverse reactions such as ...
Chunhui Gao, Bowen Ma, Wei Liu, Liqin Zhu   +3 more
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