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β-Lactam Antibiotics Renaissance
Antibiotics, 2014 Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective.
Wenling Qin +2 more
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Frontiers in Microbiology, 2023 β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar +4 more
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Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]
FEMS Microbiology Letters, 1995 A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky +3 more
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A method to transform the β-lactam antibiotic producerStreptomyces wadayamensis [PDF]
FEMS Microbiology Letters, 1986 We have developed a transformation system for Streptomyces wadayamensis, a cephamycin C producer. 1−5 × 109 protoplasts can be obtained when late logarithmic phase cultures of this microorganisms are incubated with 10 mg/ml of lysozyme. Polyethylene glycol-Ca2+-mediated transformation of these protoplasts yielded 106 transformants per μg of pIJ702 or ...
C. Acebal, V. Rubio, G. Márquez
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Spherical and rod shaped protoplasts from β-lactam antibiotic treated cultures of Bacillus subtilis [PDF]
FEMS Microbiology Letters, 1988 Addition of β-lactams to exponentially growing cultures of an autolytically deficient Bacillus subtilis metc3 lyt-2 strain FJ6 caused increase in optical density to stop after 1 h when it had about doubled, and thereafter to remain constant for at least 6 h.
G. Wright, H.J. Rogers
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Initiation of murein biosynthesis inEscherichia colicells treated with β-lactam antibiotics [PDF]
FEMS Microbiology Letters, 1987 The study of the synthesis and accumulation of murein in cells initiating growth in the presence of β-lactam antibiotics indicated: (i) Murein rearrangement contributes substantially to cell enlargement during the first doubling in cell mass; (ii) Penicillin-binding protein 2 has the potential capability to synthesize most, if not all, the new murein ...
Antonio G. Pisabarro +3 more
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NMR spectrometric assay for determining enzymatic hydrolysis of β-lactam antibiotics with bacteria in aqueous solution [PDF]
FEMS Microbiology Letters, 1984 An application of a nuclear magnetic resonance (NMR) spectrometer for the measurement of β-lactamase activity in clinical material containing bacteria is presented. By means of proton (1H)-NMR, it was easy to measure quantitatively β-lactamase activity in human bacteriuria, without performing any such pretreatment as isolation of bacteria or extraction
Koji O'hara, Yoko Shiomi, Megumi Kono
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The state and consideration for skin test of β-lactam antibiotics in pediatrics
Frontiers in Cellular and Infection Microbiology, 2023 β-lactam antibiotics are the most frequently used drugs and the most common drugs that cause allergic reactions in pediatrics. The occurrence of some allergic reactions can be predicted by skin testing, especially severe adverse reactions such as ...
Chunhui Gao +3 more
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BMC Complementary Medicine and Therapies, 2021 Background β-lactam antibiotics are a class of broad-spectrum antibiotics consisting of all antibiotic agents that contain a β-lactam ring in their molecular structures. β-lactam antibiotics are only known to be isolated from fungi (e.g.
Tiffany Turner +3 more
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Involvement of O8-antigen in altering β-lactam antibiotic susceptibilities inEscherichia coli [PDF]
FEMS Microbiology Letters, 2008 In spite of being dispensable, O-antigens are believed to facilitate various cellular processes and alter antibiotic sensitivities. Escherichia coli K-12 (CS109) strains are lacking in O-antigens and are reported to be sensitive to antibiotics. To our surprise, E. coli 2443 (expressing O8-antigen) manifested two- to fourfold higher sensitivities toward
Sujoy K, Sarkar, Anindya S, Ghosh
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