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β-Lactam Antibiotics Renaissance

Antibiotics, 2014
Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective.
Wenling Qin
exaly   +3 more sources

Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to β-lactam antibiotics [PDF]

Antimicrobial Agents and Chemotherapy
Resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus is mediated by the mecA-encoded, β-lactam-resistant transpeptidase, penicillin-binding protein 2a (PBP2a), which is capable of crosslinking peptidoglycan in the presence of
Claire Fingleton, Merve S. Zeden, Emilio Bueno, Felipe Cava, James P. O'Gara   +4 more
doaj   +2 more sources

Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon? [PDF]

Antibiotics
Pseudomonas aeruginosa is a significant threat to public health as an aggressive, opportunistic pathogen. The use of β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems remains a front-line treatment against P ...
Dylan W. Zhao, Christopher T. Lohans
doaj   +2 more sources

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics [PDF]

Advanced Science
Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance.
Julia Werner, Florian Umstätter, Manuel B. Böhmann, Hannah Müller, Barbro Beijer, Tobias Hertlein, Laura Kaschnitz, Veronika Bram, Christian Kleist, Karel D. Klika, Eric Mühlberg, Gabriel Braune, Sabrina Wohlfart, Martin Gärtner, Silke Peter, Stefan Zimmermann, Uwe Haberkorn, Knut Ohlsen, Heike Brötz‐Oesterhelt, Walter Mier, Philipp Uhl   +20 more
doaj   +2 more sources

Effect of β-lactam antibiotics on the gut microbiota of term neonates [PDF]

Annals of Clinical Microbiology and Antimicrobials
β-Lactam antibiotics are a class of antibiotics commonly used to treat bacterial infections. However, the effects of β-lactam antibiotics on term neonatal intestinal flora have not been fully elucidated. Hospitalized full-term newborns receiving β-lactam
Hongdan Gu, Enfu Tao, Yijia Fan, Gao Long, Xinyi Jia, Tianming Yuan, Lihua Chen, Xiaoli Shu, Wei Zheng, Mizu Jiang   +9 more
doaj   +2 more sources

A Spore-Based Biosensor-on-Pillar Platform for Detecting ß-Lactam Antibiotics in Milk [PDF]

Molecules
Antimicrobial resistance (AMR) is increasingly becoming a major global public health concern, as antibiotics are losing their effectiveness at an alarming rate due to drug resistance.
Sammer UƖ Hassan, Zhuoxin Liu, Prashant Goel, Naresh Kumar, Xunli Zhang   +4 more
doaj   +2 more sources

Machine learning models for coagulation dysfunction risk in inpatients administered β-lactam antibiotics [PDF]

Frontiers in Pharmacology
The β-Lactam antibiotics represent a widely used class of antibiotics, yet the latent and often overlooked risk of coagulation dysfunction associated with their use underscores the need for proactive assessment.
Yuqing Hua, Yuqing Hua, Na Li, Jiahui Lao, Zhaoyang Chen, Shiyu Ma, Xiao Li   +6 more
doaj   +2 more sources

β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment [PDF]

Frontiers in Microbiology
Understanding the impact of antibiotics on bacterial metabolism is crucial for elucidating their mechanisms of action and developing more effective therapeutic strategies.
Dongyang Ye, Dongyang Ye, Dongyang Ye, Jing Sun, Jing Sun, Ran Jiang, Jiashen Chang, Yiming Liu, Xiangzheng Wu, Luqi Li, Yihan Luo, Juan Wang, Juan Wang, Juan Wang, Kangkang Guo, Kangkang Guo, Kangkang Guo, Zengqi Yang, Zengqi Yang, Zengqi Yang   +19 more
doaj   +2 more sources

Mutations in ampD cause hyperproduction of AmpC and CmcB β-lactamases and high resistance to β-lactam antibiotics in Chromobacterium violaceum [PDF]

Microbiology Spectrum
Bacterial resistance to β-lactam antibiotics mediated by β-lactamase enzymes is widespread worldwide. Chromobacterium violaceum, an environmental Gram-negative bacterial pathogen, is intrinsically resistant to some β-lactam antibiotics.
Luís Gustavo Laranjeiro, Carlos Eduardo M. Neme, Maristela Previato-Mello, Bianca B. Batista, Isabel Henriques, José F. da Silva Neto   +5 more
doaj   +2 more sources

β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

Frontiers in Microbiology, 2023
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections.
Lekshmi Narendrakumar, Medha Chakraborty, Shashi Kumari, Deepjyoti Paul, Bhabatosh Das   +4 more
doaj   +1 more source