Results 31 to 40 of about 74,405 (237)

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, Ross, R Paul, STANTON, CATHERINE   +4 more
core   +1 more source

Comparison between a direct-flow SPR immunosensor for ampicillin and a competitive conventional amperometric device: analytical features and possible applications to real samples [PDF]

, 2017
In this research, we developed a direct-flow surface plasmon resonance (SPR) immunosensor for ampicillin to perform direct, simple, and fast measurements of this important antibiotic.
Campanella, Luigi, Favero, Gabriele, Martini, Elisabetta, Mazzei, Franco, Merola, Giovanni, Sanzo', Gabriella, Tomassetti, Mauro   +6 more
core   +2 more sources

Intrinsic Class D β-Lactamases of Clostridium difficile

mBio, 2018
Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth, Nichole K. Stewart, Clyde Smith, Sergei B. Vakulenko   +3 more
doaj   +1 more source

Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases [PDF]

, 2015
The breakdown of antibiotics by β-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors
A Bloor, A Brooun, A Ross-Gillespie, A Ross-Gillespie, AS Hackman, B Raymond, B Raymond, Ben Raymond, BR Levin, C Dahlberg, D Clark, DA Mitchison, DM Livermore, E Tuomanen, EA Yurtsev, Frances Medaney, G Rolinson, GL Hobby, HC Neu, I Brook, I Brook, JJ Harrison, JL Cottell, JW Bigger, K Datsenko, K Lewis, K Lewis, K Lewis, K Sandoz, L Dugatkin, L Zhou, M Doebeli, M Ghoul, MH Perlin, NQ Balaban, O Ciofu, PS Stewart, R Ellis, R Lenski, R Lenski, R Tacking, Richard J Ellis, RJ Worthington, RM Cozens, RN Jones, S Brown, SA West, SA West, SP Brown, SP Diggle, Tatiana Dimitriu, X-X Zhang, XX Zhang   +52 more
core   +1 more source

Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

Scientific Reports, 2020
New antigens deriving from -lloyl and -llanyl, major and minor determinants, respectively, were produced for β-lactam antibiotics cefuroxime, cefotaxime, ceftriaxone, meropenem and aztreonam.
Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira   +2 more
doaj   +1 more source

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Nature Communications, 2021
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins.
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan   +7 more
doaj   +1 more source

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Pathogens, 2021
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute and chronic infections. β-lactam antibiotics including penicillins, carbapenems, monobactams, and cephalosporins play a key role in the treatment of P.
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

Community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections in a pediatric hospital in Argentina [PDF]

, 2014
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) emerged at the Pediatric Hospital of Misiones Province, north Argentina, in 2003 as a cause of community-acquired (CA) infections, mostly associated with skin and soft tissue infections ...
Gardella, Noella Mariel, Grenon, Sandra Liliana, Gutkind, Gabriel Osvaldo, Mollerach, Marta Eugenia, Ubeda, Clotilde, Von Specht, Martha Helena   +5 more
core   +1 more source

Comparison of initial empirical antibiotic regimens in severe community-acquired pneumonia: a network meta-analysis

BMC Pulmonary Medicine
Background Severe community-acquired pneumonia (SCAP) remains a leading cause of morbidity and mortality worldwide. Identifying the optimal antibiotic regimen for treating SCAP is crucial for improving patient outcomes.
Min Wang, Jing Zhang, Xiaoming Wang, Qian Wang, Lian Wang, Han Zhuang, Ao Liu   +6 more
doaj   +1 more source

Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria

Antibiotics
Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and
Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn   +3 more
doaj   +1 more source