Results 41 to 50 of about 61,534 (259)

Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species

Antimicrobial Resistance and Infection Control, 2016
Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
doaj   +1 more source

Intrinsic Class D β-Lactamases of Clostridium difficile

mBio, 2018
Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth, Nichole K. Stewart, Clyde Smith, Sergei B. Vakulenko   +3 more
doaj   +1 more source

Profiles of phenotype resistance to antibiotic other than β-lactams in Klebsiella pneumoniae ESBLs-producers, carrying blaSHV genes.

Folia Histochemica et Cytobiologica, 2011
Extended spectrum β-lactamases production is one of the most common mechanism of resistance to extended spectrum β-lactam antibiotics is increasing worldwide. Twenty five strains of Klebsiella pneumoniae isolated from clinical specimens were tested. Based on the phenotypic confirmatory test all these strains were defined as ESBL producers named ESBL(+).
Małgorzata Krawczyk, Robert Milewski, Tomasz Hauschild, Andrzej Szpak, Piotr Wieczorek, Dominika Ojdana, Paweł Sacha, Katarzyna Kaczyńska, Elżbieta Tryniszewska   +8 more
openaire   +5 more sources

Molecular targets of β-Lactam-based antimicrobials : Beyond the usual suspects : Beyond the usual suspects [PDF]

, 2018
The common practice in antibacterial drug development has been to rapidly make an attempt to find ever-more stable and broad-spectrum variants for a particular antibiotic, once a drug resistance for that antibiotic is detected.
Monika Konaklieva (16750224)
core   +1 more source

Structures of β-lactam antibiotics with positions numbered. [PDF]

, 2015
Structures of β-lactam antibiotics with positions numbered.
Timothy Palzkill (47788), Shrenik C. Mehta (747991), Kacie Rice (747992)   +2 more
core   +1 more source

Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

Scientific Reports, 2020
New antigens deriving from -lloyl and -llanyl, major and minor determinants, respectively, were produced for β-lactam antibiotics cefuroxime, cefotaxime, ceftriaxone, meropenem and aztreonam.
Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira   +2 more
doaj   +1 more source

Additional file 2: of Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens

, 2019
Table S2.. Multivariate analysis of 90-day all-cause mortality due to neutropenic pneumonia. (DOCX 15 kb)
Seok, Hyeri, Ko, Jae-Hoon, Peck, Kyong, Kim, Ji-Yeon, Lee, Ji, Park, Ga, Cho, Sun, Kang, Cheol-In, Lee, Nam, Chung, Doo   +9 more
openaire   +1 more source

Bifunctional Beta-Lactam Antibiotics [PDF]

, 2021
The molecular structure of β-lactam antibiotics can be modified either to introduce another β-lactam ring (the pharmacophore conferring bactericidal activities to these molecules), or to add other pharmacophores that modify their pharmacological ...
Marabotti, A.
core  

Comparison of initial empirical antibiotic regimens in severe community-acquired pneumonia: a network meta-analysis

BMC Pulmonary Medicine
Background Severe community-acquired pneumonia (SCAP) remains a leading cause of morbidity and mortality worldwide. Identifying the optimal antibiotic regimen for treating SCAP is crucial for improving patient outcomes.
Min Wang, Jing Zhang, Xiaoming Wang, Qian Wang, Lian Wang, Han Zhuang, Ao Liu   +6 more
doaj   +1 more source

Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria

Antibiotics
Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and
Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn   +3 more
doaj   +1 more source