Results 21 to 30 of about 1,489,579 (226)

β-lactam/β-lactamase inhibitor combinations: an update [PDF]

, 2018
Antibiotic resistance caused by β-lactamase production continues to present a growing challenge to the efficacy of β-lactams and their role as the most important class of clinically used antibiotics.
Afd Chemical Biology and Drug Discovery, Martin, Nathaniel I, Chemical Biology and Drug Discovery, Tehrani, Kamaleddin H M E   +3 more
core   +2 more sources

High colonization rates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli [PDF]

, 2014
BACKGROUND International travel contributes to the worldwide spread of multidrug resistant Gram-negative bacteria. Rates of travel-related faecal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae vary for different ...
Battegay, Manuel, Widmer, Andreas F., Andreas Neumayr, Frei, Reno, Neumayr, Andreas, Hatz, Christoph, Jaeger, Veronika K., Veronika K Jaeger, Johannes Blum, Sabine Haller, Andreas F Widmer, Susan DeCrom, Blum, Johannes, Reno Frei, Furrer, Hansjakob, Endimiani, Andrea, Hansjakob Furrer, DeCrom, Susan, Jaeger, Veronika K, Haller, Sabine, Manuel Battegay, Andrea Endimiani, Esther Kuenzli, Widmer, Andreas F, Christoph Hatz, Kuenzli, Esther   +25 more
core   +3 more sources

Broad antibiotic resistance profile of the subclass B3 metallo-β-lactamase GOB-1, a di-zinc enzyme. [PDF]

, 2011
peer reviewedThe metallo-β-lactamase (MBL) GOB-1 was expressed via a T7 expression system in Escherichia coli BL21(DE3). The MBL was purified to homogeneity and shown to exhibit a broad substrate profile, hydrolyzing all the tested β-lactam compounds ...
Nathalie Selevsek, Carine Bebrone, Louise E. Horsfall, Lassaux, Patricia, Benoit M. R. Liénard, Kurt M. Hoffmann, Hoffmann, Kurt, Poirel, Laurent, Michael B. Kupper, Horsfall, Louise E., Horsfall, Louise E.; id_orcid, Bebrone, Carine, Izougarhane, Youssef, Jean-Marie Frère, Lienard, Benoit M. R., Youssef Izougarhane, Selevsek, Nathalie, Kupper, Michael B., Patricia Lassaux, Kupper, Michaël, Horsfall, Louise, Laurent Poirel, Liénard, Benoit, Galleni, Moreno, Frère, Jean-Marie, Hoffmann, Kurt M., Moreno Galleni   +26 more
core   +1 more source

Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species

Antimicrobial Resistance and Infection Control, 2016
Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
doaj   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Production of β-Lactamase Inhibitors by Streptomyces Species

Antibiotics, 2018
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials and β-lactamase ...
Daniela de Araújo Viana Marques, Suellen Emilliany Feitosa Machado, Valéria Carvalho Santos Ebinuma, Carolina de Albuquerque Lima Duarte, Attilio Converti, Ana Lúcia Figueiredo Porto   +5 more
doaj   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Third-generation cephalosporin resistance in clinical isolates of Enterobacterales collected between 2016–2018 from USA and Europe: genotypic analysis of β-lactamases and comparative in vitro activity of cefepime/enmetazobactam

Journal of Global Antimicrobial Resistance, 2021
: Objectives: This study aimed to investigate third-generation cephalosporin (3GC) resistance determinants [extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases and OXA-type β-lactamases] in contemporary clinical Enterobacterales isolates and to ...
Adam Belley, Ian Morrissey, Stephen Hawser, Nimmi Kothari, Philipp Knechtle   +4 more
doaj   +1 more source

Functional insights into Streptomyces isolates containing both clavulanic acid-like and carbapenem biosynthetic gene clusters

mSphere
β-Lactam antibiotics and β-lactamase inhibitor combinations are essential for combating antimicrobial resistance, with many β-lactams, including clavulanic acid (CA), themselves being products of specialized metabolic pathways in bacteria. CA is a potent
Kapil Tahlan, Arshad Ali Shaikh, Jingyu Liu, Kajal Gupta, Nader AbuSara, Santosh Kumar Srivastava, Adau Deng, Ayla Rouah, Madelyn Joan Swackhamer   +8 more
doaj   +1 more source

Isothermal Titration Calorimetric Studies of Complexation Reactions [PDF]

The objective of this work has been to study the binding of metal ions to complex ligands expressing two or more metal binding sites, in terms of the thermodynamics of the binding events, and to use this information to contribute to the understanding of ...
Motara, Hasina
core   +3 more sources