Results 31 to 40 of about 14,918 (141)

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Anti-atherosclerosis potential activity from Alphitobius diaperinus: a molecular docking study on NLRP3 receptor

Jurnal Ilmu Peternakan Terapan
This study aimed to analyze the potential activity anti-atherosclerosis of Alphitobius diaperinus larvae using molecular docking. The target receptor used was NLRP3, with β-sitosterol and campesterol as the test ligands, and simvastatin as the control ...
Firdaus Hasibuan, Erfan Andrianto Aritonang   +1 more
doaj   +1 more source

Increased Yield of Biotransformation of Androsta-1, 4-Dien-3, 17-Dione from Β-Sitosterol by Using Sulfobutyl Ether-Β-Cyclodextrin Complexation Technique

MATEC Web of Conferences, 2016
Substrate solubility in steroid biotransformation is critical for enhancing the biotransformation of hydrophobic compounds. In this study, the sulfobutyl ether-β-cyclodextrin (SBE-β-CD) complexation technique was used for the biotransformation of β ...
Wang Jingwen, Guan Shimin, Cai Baoguo, Zhang Shuo, Yang Shulin, Zhou Yue, Rong Shaofeng, Li Qianqian   +7 more
doaj   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, EarlyView.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

β-sitosterol in different parts of Saraca asoca and herbal drug ashokarista: Quali-quantitative analysis by liquid chromatography-mass spectrometry

Journal of Advanced Pharmaceutical Technology & Research, 2013
β-sitosterol is an important component in food and herbal products and beneficial in hyperlipidemia. Its higher concentrations in serum may lead to coronary artery disease in case of sitosterolemia. Therefore, it is essential to determine the quantity of
Anjum Gahlaut, Amey Shirolkar, Vikas Hooda, Rajesh Dabur   +3 more
doaj   +1 more source

Dietary β-sitosterol regulates serum lipid level and improves immune function, antioxidant status, and intestinal morphology in broilers

Poultry Science, 2020
This research investigated effects of dietary β-sitosterol addition at different levels on serum lipid levels, immune function, oxidative status, and intestinal morphology in broilers. One-day-old broiler chicks were allocated to 5 groups of 6 replicates.
Yefei Cheng, Yueping Chen, Jun Li, Hengman Qu, Yurui Zhao, Chao Wen, Yanmin Zhou   +6 more
doaj   +1 more source

EFFECT OF Β-SITOSTEROL AND GIBBERELLIC ACID ON LEAF ANGLE ,GROWTH, FLOWERING AS WELL AS BIOCHEMICAL CONSTITUENTS OF MARIGOLD (Calendula officinalis) PLANT [PDF]

Journal of Plant Production, 2008
 Marigold plant growth and orientation were improved by adding gibberellic acid (25, 50 and 100 mgL-1) and β-sitosterol (20, 40 and 80 mgL-1) as well as their interaction treatments.
A. Amin, M. Abd El-Wahed, E. Rashad
doaj   +1 more source

Optimization of Saponification Process for Quantification of Individual and Total Tocopherols and Phytosterols in Canola Oil Refining By‐Products

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT In this study, saponification variables were optimized using a face‐centred central composite design‐response surface methodology. The variables included reaction temperature (50°C–120°C), reaction time (30–180 min), KOH concentration (0.5–3 M) and pyrogallol concentration (0–1% w/v).
Milad Kazemi, Paul Prenzler, Lachlan Schwarz, Michael Loughlin, Randy Adjonu   +4 more
wiley   +1 more source

Beta-Sitosterol Facilitates GLUT4 Vesicle Fusion on the Plasma Membrane via the Activation of Rab/IRAP/Munc 18 Signaling Pathways in Diabetic Gastrocnemius Muscle of Adult Male Rats

Bioinorganic Chemistry and Applications, 2022
Nutritional overload in the form of high-fat and nonglycolysis sugar intake contributes towards the accelerated creation of reactive oxygen species (ROS), hyperglycemia, and dyslipidemia.
JinJin Pei, Monisha Prasad, Ghada Mohamed Helal, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Ponnulakshmi Rajagopal, Chella Perumal Palanisamy, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman, Krishna Mohan Surapaneni   +9 more
doaj   +1 more source