Results 221 to 230 of about 2,697,911 (252)

Acute hemolytic transfusion reaction mediated by anti-Jk^b antibody in a pediatric patient with β-thalassemia major: a case report illustrating an anamnestic alloimmune response. [PDF]

Front Immunol
Xu J, Chen J.
europepmc   +1 more source

Persistent thrombocytosis in β-thalassemia post-splenectomy: A STROBE-compliant retrospective cohort study at a Jordanian referral center. [PDF]

Medicine (Baltimore)
Alesufi A, Abu Lehyah NAA, Abu Nasrieh D, Banihani HA, Aburumman S, Zibara Z, Fakih N, Al-Karmi L, Al Nawaiseh MA, Shersheer Q, Shersheer Q.   +10 more
europepmc   +1 more source

Low- to moderate-dose thalidomide combination rescue after luspatercept failure in transfusion-dependent β-thalassemia: a real-world cohort study. [PDF]

Ann Hematol
Nanthachak S, Wen C, Gan Z, Pan L, Liu R, Huang Y.   +5 more
europepmc   +1 more source

β-Thalassemia

Genetics in Medicine, 2017
β-Thalassemia is caused by reduced (β +) or absent (β 0) synthesis of the β-globin chains of hemoglobin. Three clinical and hematological conditions of increasing severity are recognized: the β-thalassemia carrier state, thalassemia intermedia, and ...
Raffaella Origa
exaly   +2 more sources

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Global distribution of β-thalassemia mutations: An Update.

Gene, 2023
One excellent illustration of how a single gene abnormality may result in a spectrum of disease incidence is the incredible phenotypic variety of β-thalassemia, which spans from severe anemia and transfusion needs to an utterly asymptomatic sickness ...
E. Rao, Sandip Kumar Chandraker, Mable Misha Singh, Ravindra Kumar   +3 more
semanticscholar   +1 more source

Pretransfusion hemoglobin level and mortality in adults with transfusion-dependent β-thalassemia.

Blood, 2023
In a large cohort of patients with transfusion-dependent β-thalassemia, we demonstrate an association between ascending pretransfusion hemoglobin levels starting at 9.5 g/dL and reduced mortality risk.
K. Musallam, Susanna Barella, R. Origa, G. B. Ferrero, Roberto Lisi, A. Pasanisi, Filomena Longo, Barbara Gianesin, G. Forni   +8 more
semanticscholar   +1 more source

Prevalence and Management of β-Thalassemia in India

Hemoglobin, 2022
India bears a huge burden of hemoglobinopathies, and the most prevalent is thalassemia. The different types of thalassemia include minor, major and intermedia, based on the α/β-globin chain inequality.
S. Yadav, P. Panchal, Kavitha Menon
semanticscholar   +1 more source

Rapid and simultaneous detection of β- thalassemia point mutations by reverse hybridization strip assay among Egyptian patients

Journal of Biochemistry, Microbiology and Biotechnology, 2016
Thalassemia is a wide range hereditary disease with high incidence in Egypt along with the high frequency of consanguineous marriages. Investigation the heterogeneity, molecular basis, and natural history are the most effective methods to deal with the thalassemia to develop effective method for management and prevention including the prenatal ...
Osama Shalaan, Moustafa Sakr, Ahmed Daif, Khalil Elhalfawy   +3 more
openaire   +1 more source

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia.

New England Journal of Medicine, 2020
BACKGROUND Patients with transfusion-dependent β-thalassemia need regular red-cell transfusions. Luspatercept, a recombinant fusion protein that binds to select transforming growth factor β superfamily ligands, may enhance erythroid maturation and reduce
M. Cappellini, V. Viprakasit, A. Taher, P. Georgiev, K. Kuo, T. Coates, E. Voskaridou, H. Liew, Idit Pazgal-Kobrowski, G. Forni, S. Perrotta, A. Khelif, A. Lal, A. Kattamis, E. Vlachaki, R. Origa, Y. Aydinok, M. Bejaoui, P. Ho, Ping-Chew Lee, P. Bee, Soo-Min Lim, Meng-Yao Lu, A. Tantiworawit, P. Ganeva, L. Gercheva, F. Shah, E. Neufeld, A. Thompson, A. Laadem, J. Shetty, J. Zou, Jen-Nie Zhang, D. Miteva, T. Zinger, P. Linde, M. Sherman, O. Hermine, J. Porter, A. Piga   +39 more
semanticscholar   +1 more source

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia.

New England Journal of Medicine
BACKGROUND Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis through ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing of the erythroid-specific ...
F. Locatelli, Peter Lang, Donna Wall, Roland Meisel, S. Corbacioglu, Amanda M. Li, J. de la Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, M. Mapara, R. Liem, M. Cappellini, M. Algeri, A. Kattamis, Sujit Sheth, Stephan A. Grupp, R. Handgretinger, Puja Kohli, D. Shi, Leorah Ross, Y. Bobruff, C. Simard, Lanju Zhang, Phuong K Morrow, W. Hobbs, H. Frangoul   +26 more
semanticscholar   +1 more source