Results 1 to 10 of about 779,152 (196)

The prevalence of thalassemia in mainland China: evidence from epidemiological surveys

Scientific Reports, 2017
Comprehensive data regarding the epidemiology and prevalence of thalassemia in mainland China are lacking. To assess the prevalence of thalassemia, we performed a meta-analysis including 16 articles published from 1981 to 2015.
Ketong Lai, Guifeng Huang, Li Su, Yunyan He   +3 more
doaj   +1 more source

Gene Mutation Spectrum of Thalassemia Among Children in Yunnan Province

Frontiers in Pediatrics, 2020
Background: Thalassemia is an autosomal genetic disorder, found throughout the world. It is still not treatable and create socio economic problems. In this study, we investigated the prevalence and spectrum features of thalassemia in Yunnan Province, the
Ti-Long Huang, Tian-Yao Zhang, Chun-Yan Song, Yun-Bi Lin, Bao-Hua Sang, Qing-Ling Lei, Yu Lv, Chun-Hui Yang, Na Li, Xin Tian, Yue-Huang Yang, Xian-Wen Zhang   +11 more
doaj   +1 more source

Evaluation of efficiencies of MCV, HbH inclusion body test and Gap-PCR in the screening of α-thalassemia: A case study of Lampang Hospital

Journal of Associated Medical Sciences, 2009
α-thalassemia is characterized by quantitive abnormality of α-globin chain commonly occur in Thailand. Heterozygote of α-thalassemia is clinically asymtomatic, but with modest alteration of hematologic parameters.
Tiemjan Kewkarnkha, Surasit Suwannasin, Thanusak Tatu   +2 more
doaj  

Predicting factors of survival rates among alpha- and beta-thalassemia patients: a retrospective 10-year data analysis

Frontiers in Hematology
BackgroundThalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications.
Kunapa Iam-arunthai, Tawatchai Suwanban, Pravinwan Thungthong, Supat Chamnanchanunt, Supat Chamnanchanunt, Suthat Fucharoen   +5 more
doaj   +1 more source

PBI22 Rethinking the Health-Economic Evaluation Framework for GENE Therapies: The Betibeglogene Autotemcel (BETI-CEL) Case in Î’-Thalassemia [PDF]

Value in Health, 2020
L. Undreiner, M. Caillon, C. Paramore, S. Roze   +3 more
openaire   +1 more source

Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort

Hematology
Background: Hemoglobin (Hb) Hekinan is a prevalent α-globin variant frequently missed in thalassemia screening centers using high-performance liquid chromatography (HPLC) or capillary electrophoresis.
Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert   +5 more
doaj   +1 more source

Molecular and Hematological Characterization of α-Thalassemia in Denizli Province

Acta Haematologica Oncologica Turcica
Aim: Alpha thalassemia, a common monogenic disorder, occurs with defective synthesis of the α-globin chain and has a very wide clinical spectrum depending on the disorders in the globin genes.
Derya Karaer, Tuba Uğurlu Er, Nevin Alayvaz Aslan, Taner Durak   +3 more
doaj   +1 more source

The prevalence and molecular spectrum of α- and β-globin gene mutations in 14,332 families of Guangdong Province, China.

PLoS ONE, 2014
ObjectiveTo reveal the familial prevalence and molecular variation of α- and β-globin gene mutations in Guangdong Province.MethodsA total of 40,808 blood samples from 14,332 families were obtained and analyzed for both hematological and molecular ...
Aihua Yin, Bing Li, Mingyong Luo, Longchang Xu, Li Wu, Liang Zhang, Yuanzhu Ma, Tingting Chen, Shuang Gao, Juqing Liang, Hao Guo, Danqing Qin, Jicheng Wang, Tenglong Yuan, Yixia Wang, Wei-wei Huang, Wen-Fei He, Yanxia Zhang, Chang Liu, Sujian Xia, Qingshan Chen, Qingguo Zhao, Xiaozhuang Zhang   +22 more
doaj   +1 more source

Analysis of genotypic distribution and rare variants of patients with α/β-thalassemia screened in one hospital in Beijing, China

Human Genomics
Objective Thalassemia is among the most common inherited diseases worldwide. We aimed to analyze the genotype and frequency distribution of thalassemia in a general hospital in Beijing and provide a reference for genetic counseling and prenatal diagnosis.
Han Zhang, Ziran Wang, Zhuo Yang, Xinfei Chen, Hongrui Xu, Xianhui Zeng, Qi Yu, Lingjun Kong, Rui Zhang, Jie Yi, Jie Wu, Yong Gan, Yu Chen, Ali Ye, Ziyi Wang, Dong Zhang, Xiao Han, Juan Du, Yaling Dou   +18 more
doaj   +1 more source

Application of electrospray triple quadrupole mass spectrometry in assessing thalassemia in a population

Indian Journal of Pathology and Microbiology
Introduction: Thalassemia is widely prevalent in Asian countries and the Middle East region of the world. While the prevalence of α thal is around 5-20% in the population, the incidence of β thal is around 3-4%.
Deepalakshmi D. Putchen, Athira Nambiar, Ashwini Bijur, Nelson Amirtharaj, Sujay Ramaprasad   +4 more
doaj   +1 more source