Results 11 to 20 of about 1,044,639 (194)

Sensitivitas dan Spesifisitas α-Globin Strip Assay dalam Mendeteksi Mutasi Thalassemia-α

Sari Pediatri, 2016
Latar belakang. Thalassemia-α merupakan kelainan genetik yang dapat menyebabkan gejala klinis berat pada pasien. Deteksi mutasi thalassemia-α di Indonesia umumnya menggunakan metode PCR sebagai baku emas.
Dian Puspita Sari, Pustika Amalia Wahidiyat   +1 more
doaj   +2 more sources

Thalassemia and Hemoglobin E in Southern Thai Blood Donors [PDF]

Advances in Hematology, 2014
Thalassemia and hemoglobin E (Hb E) are common in Thailand. Individuals with thalassemia trait usually have a normal hemoglobin concentration or mild anemia. Therefore, thalassemic individuals who have minimum acceptable Hb level may be accepted as blood
Manit Nuinoon, Kwanta Kruachan, Warachaya Sengking, Dararat Horpet, Ubol Sungyuan   +4 more
doaj   +2 more sources

β-Thalassemia Intermedia: Interaction of α-Globin Gene Triplication With β-thalassemia Heterozygous in Spain

Frontiers in Medicine, 2022
ObjectivesTo verify with hematimetric data that the diagnosis and clinical grade of β-TI can be established when a triplication of alpha genes (αααanti 3.7) and heterozygous β-thalassemia coexist.Materials and MethodsRetrospective study in which 73 ...
Paloma Ropero, Paloma Ropero, Fernando Ataúlfo González Fernández, Jorge M. Nieto, Jorge M. Nieto, Williana Melissa Torres-Jiménez, Celina Benavente   +6 more
doaj   +2 more sources

Analysis of genotypic distribution and rare variants of patients with α/β-thalassemia screened in one hospital in Beijing, China

Human Genomics
Objective Thalassemia is among the most common inherited diseases worldwide. We aimed to analyze the genotype and frequency distribution of thalassemia in a general hospital in Beijing and provide a reference for genetic counseling and prenatal diagnosis.
Han Zhang, Ziran Wang, Zhuo Yang, Xinfei Chen, Hongrui Xu, Xianhui Zeng, Qi Yu, Lingjun Kong, Rui Zhang, Jie Yi, Jie Wu, Yong Gan, Yu Chen, Ali Ye, Ziyi Wang, Dong Zhang, Xiao Han, Juan Du, Yaling Dou   +18 more
doaj   +2 more sources

Platelet-Derived Microparticle Count in β-Thalassemia Patients with Direct Labeling Monoclonal Antibody CD62P and CD41 [PDF]

Majalah Kedokteran Bandung, 2020
Thromboembolic events are potentially life-threatening clinical complications found in β-thalassemia patients. The pathogenesis of the hypercoagulable state in β-thalassemia patients results from the degradation of excess α-globin chains in red blood cells, leading to intracellular labile iron accumulation, oxidative stress, and more rigid, deformed,
Ivan Lumban Toruan, Pandji Irani Fianza, Delita Prihatni   +2 more
openaire   +2 more sources

Investigating the level of Hba1c and insulin level in β-thalassemia patients

MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan, 2023
Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.Objective: This study aimed to ...
Husnan Mujiburrahman, Qodri Santosa, Joko Setyono, Nendyah Roestijawati, Lantip Rujito   +4 more
openaire   +2 more sources

Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia
Ade Hariza Harahap, Bidasari Lubis, Herman Hariman   +2 more
openaire   +1 more source

A particular focus on the prevalence of α-thalassemia and β-thalassemia among pregnant women in Changsha County, Hunan Province. [PDF]

Front Genet
BackgroundThalassemia is a inherited monogenic blood disorder and more prevalent in southern China. In this study, Our aim was to elucidate the molecular spectrum and phenotypic features of thalassemia in pregnant women in Changsha County.MethodsNext ...
Xia Y, Huang C, Yang M, Zhang M, Lu Y.
europepmc   +2 more sources

Epidemiology of thalassemia among the hill tribe population in Thailand.

PLoS ONE, 2021
BackgroundThalassemia is a severe disease that occurs due to abnormalities in hemoglobin genes. Various genetic factors in different populations lead to different clinical manifestations of thalassemia disease, particularly among people who have a long ...
Tawatchai Apidechkul, Fartima Yeemard, Chalitar Chomchoei, Panupong Upala, Ratipark Tamornpark   +4 more
doaj   +1 more source

Molecular Epidemiology and Hematologic Characterization of Thalassemia in Guangdong Province, Southern China

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction: About 2% of the population in the world are carriers of the thalassemia gene. Thalassemia is highly prevalent in Southern China, and traditional clinical testing methods would cause missed diagnosis of partial static thalassemia.
Jiajia Xian MD, Yanchao Wang MD, Jianchun He MD, Shaoying Li MD, Wenzhi He MD, Xiaoyan Ma MD, Qing Li PhD   +6 more
doaj   +1 more source