Results 1 to 10 of about 2,697,911 (252)

Membranoproliferative glomerulonephritis in β-thalassemia intermedia; a case report [PDF]

Journal of Nephropathology, 2022
Introduction: β-thalassemia intermedia reduces the body’s ability to produce adult hemoglobin and causes anemia. In contrast to β-thalassemia major, β-thalassemia intermedia patients do not require lifelong transfusion and are often independent of blood ...
Maryam Shafiee, Seyed Alireza Zomorodian, Seyed Mohammad Owji, Jamshid Roozbeh Shahroodi, Mahsa Torabi Jahromi   +4 more
doaj   +3 more sources

Long-term safety and erythroid response with luspatercept treatment in patients with β-thalassemia

Therapeutic Advances in Hematology, 2022
Background: β-thalassemia is a hereditary blood disorder resulting in ineffective erythropoiesis and anemia. Management of anemia with regular blood transfusions is associated with complications including iron overload.
Antonio Piga, Filomena Longo, Maria Rita Gamberini, Ersi Voskaridou, Paolo Ricchi, Vincenzo Caruso, Antonello Pietrangelo, Xiaosha Zhang, Jeevan K. Shetty, Kenneth M. Attie, Immacolata Tartaglione   +10 more
doaj   +2 more sources

The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia [PDF]

Annals of Hematology
β-thalassemia is an inherited blood disorder with long-term associated complications. The purpose of this study was to evaluate the clinical significance of the lncRNA-HBBP1 and lncRNA-XIST expression profiles in the diagnosis of β-thalassemia patients ...
Abdallah M. Gameel, Shimaa Abdelsattar, Zeinab A. Kasemy, Mai El-Sayad Abd El-Hamid, Eman Masoud Abd ElGayed, Basma M. Abdelgawed, Amira Fathy El-Fiky, Mariam E. Labib, Sabry M. Abdelmageed, Mahmoud Ahmed El Hawy, Yasmin Mohsen, Hanan M. Bedair   +11 more
doaj   +2 more sources

Changes in coagulation status in patients with β-thalassemia in Iraq: A case-control study

Medical Journal of Babylon, 2022
Background: The pathogenesis β-thalassemia is characterized by anemia resulting from reduced β-globin synthesis with low hemoglobin A (HbA) production and higher production of hemoglobin A2 (HbA2) and fetal hemoglobin (HbF).
Hussein Abdalzehra Wadaha, Hassan Dede Meshay, Mohammed Haseeb Khamees   +2 more
doaj   +1 more source

Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia

Blood, 2023
Background: Exagamglogene autotemcel (exa-cel) is a non-viral cell therapy designed to reactivate fetal hemoglobin (HbF) via ex vivo CRISPR-Cas9 gene-editing of autologous CD34+ hematopoietic stem and progenitor cells (HSPCs) at the erythroid-specific ...
F. Locatelli, Peter Lang, S. Corbacioglu, Donna Wall, R. Meisel, Amanda M. Li, J. de la Fuente, Ami J. Shah, Ben Carpenter, J. Kwiatkowski, M. Mapara, R. Liem, M. Cappellini, M. Algeri, A. Kattamis, Sujit Sheth, S. Grupp, Puja Kohli, D. Shi, Leorah Ross, Y. Bobruff, C. Simard, Lanju Zhang, Phuong K Morrow, W. Hobbs, H. Frangoul   +25 more
semanticscholar   +1 more source

Compound Heterozygous Sickle Cell-β-Thalassemia: A Case Report from Upper Assam, India [PDF]

National Journal of Laboratory Medicine, 2016
Sickle cell-β-thalassemia [Hb S/β- thalassemia] is a rare type of hemoglobinopathy. The clinical characteristics of Hb S/β- thalassemia are highly variable from a completely asymptomatic state to a severe disorder like homozygous sickle cell disease.
Anju Barhai Teli , Rumi Deori , Sidhartha Protim Saikia , Bipul Ch. Kalita   +3 more
doaj   +1 more source

Management of transfusion-dependent β-thalassemia (TDT): Expert insights and practical overview from the Middle East.

Blood reviews, 2023
β-Thalassemia is one of the most common monogenetic diseases worldwide, with a particularly high prevalence in the Middle East region. As such, we have developed long-standing experience with disease management and devising solutions to address ...
A. El-Beshlawy, Hany Dewedar, S. Hindawi, S. Alkindi, A. Tantawy, Mohamed A. Yassin, A. Taher   +6 more
semanticscholar   +1 more source

Cardiovascular Complications in β-Thalassemia: Getting to the Heart of It

Thalassemia Reports, 2023
Beta thalassemia is an inherited disorder resulting in abnormal or decreased production of hemoglobin, leading to hemolysis and chronic anemia. The long-term complications can affect multiple organ systems, namely the liver, heart, and endocrine ...
N. Akiki, M. H. Hodroj, R. Bou-Fakhredin, Kamal Matli, A. Taher   +4 more
semanticscholar   +1 more source

A Prospective Study for the Outcomes of Thalassemia in Kirkuk 2016 [PDF]

Kirkuk Journal of Science, 2017
Background: Thalassemia is one of the most globally common chronic hematological disorder. This inherited disorder is characterized by an abnormal production of hemoglobin protein resulting in a life-threatening disease of two main types α and β.In ...
Asal Aziz Tawfeeq
doaj   +1 more source

Assessment of Molecular Changes of Transfusion Dependent Beta Thalassemia Children in El Minia Governorate and Their Correlations with Patients Clinical Outcomes [PDF]

Minia Journal of Medical Research, 2020
Beta Thalassemia represents a major public health problem in Egypt. The carrier rate varies between 5.5% to > 9%. It is estimated that there are 1000/1.5 million per year live births born with beta thalassemia.(1) β thalassemia occurs when there is a ...
, Aliaa Hegazi, Mohamed Mahgoub, Lina Mahmoud, Gehan Abdel Hakeem   +3 more
doaj   +1 more source