Results 21 to 30 of about 2,697,911 (252)

Investigating the level of Hba1c and insulin level in β-thalassemia patients

MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan, 2023
Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.Objective: This study aimed to ...
Husnan Mujiburrahman, Qodri Santosa, Joko Setyono, Nendyah Roestijawati, Lantip Rujito   +4 more
openaire   +2 more sources

Economic and clinical burden of managing transfusion-dependent β-thalassemia in the United States

Journal of Medical Economics, 2023
Aims To describe clinical complications, treatment use, healthcare resource utilization (HCRU), and costs among patients with transfusion-dependent β-thalassemia (TDT) in the United States. Materials and methods Merative MarketScan Databases were used to
C. Udeze, K. Evans, Yoojung Yang, T. Lillehaugen, Janna Manjelievskaia, U. Mujumdar, Nan-Xin Li, B. Andemariam   +7 more
semanticscholar   +1 more source

Understanding the Intricacies of Iron Overload Associated with β-Thalassemia: A Comprehensive Review

Thalassemia Reports, 2023
β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to a decrease in levels of Hemoglobin A.
Subhangi Basu, Motiur Rahaman, T. Dolai, P. Shukla, Nishant Chakravorty   +4 more
semanticscholar   +1 more source

Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia
Ade Hariza Harahap, Bidasari Lubis, Herman Hariman   +2 more
openaire   +1 more source

GENE THERAPY AND GENE EDITING FOR β THALASSEMIA

Hematology/Oncology Clinics of North America, 2023
After many years of intensive research, emerging data from clinical trials indicate that gene therapy for transfusion-dependent β-thalassemia is now possible.
Georgios E Christakopoulos, Raul Telange, Jonathan S. Yen, Mitchell J. Weiss   +3 more
semanticscholar   +1 more source

Molecular Characterization of α- and β-Thalassaemia Among Children From 1 to 10 Years of Age in Guangxi, A Multi-Ethnic Region in Southern China

Frontiers in Pediatrics, 2021
Background: Thalassemia is one of the most common genetic diseases in southern China. Howerver, population in different regions or different population has their own spectrums of thalassemia.
Sheng He, Dongming Li, Shang Yi, Xiuning Huang, Chaofan Zhou, Biyan Chen, Yangjin Zuo, Li Lin, Faqin Chen, Hongwei Wei   +9 more
doaj   +1 more source

Global burden and unmet needs in the treatment of transfusion-dependent β-thalassemia

Frontiers in Hematology, 2023
Beta thalassemia (β-thalassemia) is part of a group of inherited hemoglobinopathies caused by a mutation in the beta globin gene, leading to minimal functional hemoglobin and resulting in damaged red blood cells and anemia.
G. Forni, G. Grazzini, J. Boudreaux, V. Agostini, L. Omert   +4 more
semanticscholar   +1 more source

β-thalassemia mutations identified among 2,555 at-risk couples for β-thalassemia diseases including β⁰- thalassemia (2,479 alleles) and β⁺-thalassemia (224 alleles) and unknown (24 alleles).

, 2023
β-thalassemia mutations identified among 2,555 at-risk couples for β-thalassemia diseases including β0- thalassemia (2,479 alleles) and β+-thalassemia (224 alleles) and unknown (24 alleles).
Supawadee Yamsri (15295465), Attawut Chaibunruang (15295468), Kanokwan Sanchaisuriya (632577), Supan Fucharoen (632578), Hataichanok Srivorakun (632574), Kritsada Singha (632575), Goonnapa Fucharoen (632576)   +6 more
core   +1 more source

Betibeglogene Autotemcel Gene Therapy for Non-β0/β0 Genotype β-Thalassemia.

New England Journal of Medicine, 2021
BACKGROUND Betibeglogene autotemcel (beti-cel) gene therapy for transfusion-dependent β-thalassemia contains autologous CD34+ hematopoietic stem cells and progenitor cells transduced with the BB305 lentiviral vector encoding the β-globin (βA-T87Q) gene.
F. Locatelli, A. Thompson, J. Kwiatkowski, J. Porter, A. Thrasher, S. Hongeng, M. Sauer, I. Thuret, A. Lal, M. Algeri, J. Schneiderman, T. Olson, B. Carpenter, P. Amrolia, U. Anurathapan, A. Schambach, C. Chabannon, M. Schmidt, Ivan Labik, H. Elliot, Rui-Ting Guo, M. Asmal, R. Colvin, M. Walters   +23 more
semanticscholar   +1 more source

Prevalence of iron-deficiency anemia in pregnant women with various thalassemia genotypes: Thoughts on iron supplementation in pregnant women with thalassemia genes

Frontiers in Nutrition, 2022
BackgroundThere are limited studies on iron-deficiency anemia (IDA) in carriers of various thalassemia genotypes. However, for pregnant women (PW) with high iron demand, ignoring the phenomenon of carrying the thalassemia genes combined with IDA may lead
Min Wang, Xiaozhuang Zhang, Yanhong Zhao, Yubin Zhang, Yan Lin, Meifang Xiao, Ling Li   +6 more
doaj   +1 more source