Results 11 to 20 of about 2,697,911 (252)
Majalah Kedokteran Bandung, 2015 Iron overload is the common cause of morbidity and mortality in severe β-thalassemia patients. Many factors influence the iron status in severe β-thalassemia.
Susi Susanah, Ponpon Idjradinata
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Frontiers in Medicine, 2022 Objectives To verify with hematimetric data that the diagnosis and clinical grade of β-TI can be established when a triplication of alpha genes (αααanti 3.7) and heterozygous β-thalassemia coexist.
P. Ropero +4 more
semanticscholar +2 more sources
Pathomechanisms of Immunological Disturbances in β-Thalassemia
International Journal of Molecular Sciences, 2021 Thalassemia, a chronic disease with chronic anemia, is caused by mutations in the β-globin gene, leading to reduced levels or complete deficiency of β-globin chain synthesis.
Anna Gluba-Brzózka +5 more
semanticscholar +2 more sources
A novel HBD gene mutation associated with normal-range hb A2 in β-thalassemia carriers
Annals of Hematologyβ-thalassemia is one of the most common single-gene inherited conditions in the world, prevalence of β-thalassaemia in south China is 3–4%,increased Hb A2 level is one of the most important markers of β-thalassemia heterozygous carriers.Interaction of ...
Lei Zhang +8 more
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Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β–Thalassemia [PDF]
Biomolecules, 2021 Thalassemia, an inherited quantitative globin disorder, consists of two types, α– and β–thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or even severe.
Nur Atikah Zakaria +7 more
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Annals of MedicineBackground Thalassemia is the most common hereditary anemia worldwide. Beta-thalassemia results from mutations in HBB gene, causing either absent (β0) or decreased (β+) production of β-globin.
Punwadee Rukwong +7 more
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Genotypic-Phenotypic Correlations in Non-HbE β-Thalassemia Intermedia: A Geographic Systematic Review. [PDF]
Mol Genet Genomic Medβ‐Thalassemia intermedia exhibits distinct region‐specific molecular patterns shaped by three interacting genetic axes: β‐globin mutation severity, HbF‐inducing modifiers, and α‐globin gene dosage. Mediterranean populations are predominantly mutation‐driven, Middle Eastern populations rely on HbF compensation, and Asian populations are governed by ...
Fernando K, Perera S, Premawardhena A.
europepmc +2 more sources
Platelet-Derived Microparticle Count in β-Thalassemia Patients with Direct Labeling Monoclonal Antibody CD62P and CD41 [PDF]
Majalah Kedokteran Bandung, 2020 Thromboembolic events are potentially life-threatening clinical complications found in β-thalassemia patients. The pathogenesis of the hypercoagulable state in β-thalassemia patients results from the degradation of excess α-globin chains in red blood cells, leading to intracellular labile iron accumulation, oxidative stress, and more rigid, deformed,
Ivan Lumban Toruan +2 more
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CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia.
New England Journal of Medicine, 2020 Transfusion-dependent β-thalassemia (TDT) and sickle cell disease (SCD) are severe monogenic diseases with severe and potentially life-threatening manifestations. BCL11A is a transcription factor that represses γ-globin expression and fetal hemoglobin in
H. Frangoul +25 more
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Frontiers in Pediatrics, 2022 BackgroundThalassemia is one of the most common genetic diseases in southern China. Accurate population frequency data regarding the occurrence and distribution of thalassemia are important for designing appropriate prevention strategies for thalassemia.
Ying Yu +11 more
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