Results 11 to 20 of about 920,848 (226)

Hubungan Tipe Thalassemia β serta Polimorfisme c.-582 A>G Promotor Gen HAMP dan Status Besi thalassemia β Berat Baru

Majalah Kedokteran Bandung, 2015
Iron overload is the common cause of morbidity and mortality in severe β-thalassemia patients. Many factors influence the iron status in severe β-thalassemia.
Susi Susanah, Ponpon Idjradinata
doaj   +2 more sources

Identification of β-globin gene mutations among transfusion-dependent β-thalassemia patients

Iraqi Journal of Hematology
BACKGROUND: β-thalassemias are widely distributed in Mediterranean and Middle Eastern countries, including Iraq. There are more than 400 transfusion-dependent β-thalassemia patients registered in the thalassemia center.
Haidar Hussein Al-Fatlawi, Bassam Mahammad Hameed   +1 more
doaj   +2 more sources

Vitamin D, Calcium and Phosphor in Patients with β-Thalassemia Major [PDF]

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2019
There has been many reports that patients with β-thalassemia major have bone problems such as thinning of the bone, bone fragility and pathological fractures. For so many years it was believed that the bone problems is mainly caused by marrow expansion due to compenstation of the bone marrow to handle the chronic anaemia and hiypoxia in β-thalassemia
Ade Hariza Harahap, Bidasari Lubis, Herman Hariman   +2 more
openaire   +1 more source

Molecular Characterization of α- and β-Thalassaemia Among Children From 1 to 10 Years of Age in Guangxi, A Multi-Ethnic Region in Southern China

Frontiers in Pediatrics, 2021
Background: Thalassemia is one of the most common genetic diseases in southern China. Howerver, population in different regions or different population has their own spectrums of thalassemia.
Sheng He, Dongming Li, Shang Yi, Xiuning Huang, Chaofan Zhou, Biyan Chen, Yangjin Zuo, Li Lin, Faqin Chen, Hongwei Wei   +9 more
doaj   +1 more source

Development of the Quality of Life Questionnaire (SF-36) for Patients with β-Thalassemia Major and β-Thalassemia Intermedia Based on Extended Rasch Analysis

, 2021
The quality of life (QoL) questionnaire (SF-36) contains 36 questions in eight subscales. It requires much time to fill in by the respondent. The objective of this study was to use Rasch models to develop a questionnaire that brings the desired outcome ...
Safizadeh, H, Sharifi, F, Bahrampour, A
core   +1 more source

Transcriptional Repressors of Fetal Globin Genes as Novel Therapeutic Targets in Beta-Thalassemia [PDF]

, 2020
During development the human β-globin gene cluster undergoes two switching processes at the embryo-fetal and fetal-adult stages, respectively, involving changes in chromatin remodeling and in transcriptional regulatory networks. In particular, during the
Raffaele Sessa, Marianna De Martino, Michela Grosso, Mariarosaria Giuliano, Paola Izzo, Alessandra Lo Bianco, Silvia Trombetti, Rosa Catapano, Maria Rosaria Storino   +8 more
core   +1 more source

Supplementary Material for: Analysis of hematological indices and splenectomy rates in 2,130 patients with Hemoglobin H diseases or β-thalassemia

, 2023
Introduction Splenomegaly and hypersplenism are common complications of thalassemia patients due to the excessive clearance of defective red blood cells from the spleen.
Shang H. (16810938), Ye Y. (3230418), Li P. (4157617), Xu X. (2878946), Qin L. (4762131), Zhang X. (3333504), Wang L. (3116751), Xiao B. (16810941), Li Y. (3218205), Zhang Y. (2828780)   +9 more
core   +1 more source

Prevalence of iron-deficiency anemia in pregnant women with various thalassemia genotypes: Thoughts on iron supplementation in pregnant women with thalassemia genes

Frontiers in Nutrition, 2022
BackgroundThere are limited studies on iron-deficiency anemia (IDA) in carriers of various thalassemia genotypes. However, for pregnant women (PW) with high iron demand, ignoring the phenomenon of carrying the thalassemia genes combined with IDA may lead
Min Wang, Xiaozhuang Zhang, Yanhong Zhao, Yubin Zhang, Yan Lin, Meifang Xiao, Ling Li   +6 more
doaj   +1 more source

Two novel deletion mutations in β-globin gene cause β-thalassemia trait in two Chinese families

Human Genomics, 2023
Background β-Thalassemia is mainly caused by point mutations in the β-globin gene cluster. With the rapid development of sequencing technic, more and more variants are being discovered.
Xiuqin Bao, Danqing Qin, Jicheng Wang, Jing Chen, Cuize Yao, Jie Liang, Kailing Liang, Yixia Wang, Yousheng Wang, Li Du, Aihua Yin   +10 more
doaj   +1 more source

THE CORRELATION OF β/α MRNA RATIO WITH CLINICAL AND HEMATOLOGICAL PARAMETERS IN PATIENTS WITH β-THALASSEMIA SYNDROME

The Iraqi Journal of Medical Sciences, 2022
Background: Thalassemias are a group of genetically transmitted blood diseases characterized by defects in the production of α- or β-chains of hemoglobin called α-thalassemia and β-thalassemia, respectively.
May H. Yousif, Hind S. Al-Mamoori
doaj   +1 more source