Results 41 to 50 of about 920,848 (226)

Highlights on the Luspatercept Treatment in Thalassemia

, 2023
Luspatercept has been shown to act as a ligand trap, selectively suppressing the deleterious effects of GDF11 that blocks terminal erythroid maturation, restoring normal erythroid differentiation and improving anemia in animal models of &beta ...
Yesim Aydinok
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The Associations between HLA DQB1 different Alleles and β-thalassemia Major [PDF]

Minia Journal of Medical Research, 2020
Thalassemias are the commonest inherited hemoglobinopathies in the world. Approximately 68,000 children are born with various thalassemia syndromes each year. β-Thalassemia represents a major public health problem in Egypt. beta thalassemia. It is caused
Amel Kamal Eldin, ,Emad Abd El Naem, Mostafa Elsayed, Nada Zaki Mahmoud   +3 more
doaj   +1 more source

Prevalence of B-Thalassemia Carriers Among a Cohort of University Students in Hawler Province of Iraqi Kurdistan

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512), 2017
         A representative sample of a thousand volunteer university students was screened for evidence of thalassemia minor.Complete blood counts using automated blood cell analysers and blood smears were examined. Patients having anemia, abnormal red cell indices or morphological features of thalassemia minor like hypochromia, microcytosis, target ...
Abdulkadir A. Alnakshabandi, Huda A. Muhammad   +1 more
openaire   +3 more sources

‘Phenoconversion’ in adult patients with β-thalassemia [PDF]

, 2023
To the Editor: Patients with clinically significant forms of β-thalassemia have been historically classified as having a β-thalassemia major or β-thalassemia intermedia phenotype, with the first primarily referring to patients who present with severe ...
Roberto Lisi, Lucia De Franceschi, Annamaria Pasanisi, Khaled M. Musallam, Giovanni Battista Ferrero, Barbara Gianesin, Susanna Barella, Filomena Longo, Raffaella Origa, Gian Luca Forni   +9 more
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Clinical and hematological characteristics of beta-plus thalassemia and uncommon beta-chain hemoglobin variants in Northern Thailand

Annals of Medicine
Background Thalassemia is the most common hereditary anemia worldwide. Beta-thalassemia results from mutations in HBB gene, causing either absent (β0) or decreased (β+) production of β-globin.
Punwadee Rukwong, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Chane Choed-Amphai, Adisak Tantiworawit, Kanda Fanhchaksai, Supawadee Maneekesorn, Pimlak Charoenkwan   +7 more
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The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

Frontiers in Genetics, 2022
Background: Thalassemia is a common inherited hematological disease with genetic disorders characterized by imbalanced synthesis of the globin chains.
Jingxian Ding, Zhaohui Huang, Xiaoliu Jiang, Qingge Li, Yali Cao, Yonghong Guo   +5 more
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Genotypic distribution of thalassemia in pregnant women in Nanning, Guangxi, and its impact on pregnancy outcomes

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the genotypic distribution of thalassemia in pregnant women in Nanning, Guangxi, and its impact on pregnancy outcomes.Methods·A retrospective cohort study was conducted among 3 649 pregnant women enrolled from January 2021 to ...
Li Jing, Liang Xuxia, Wu Hua, Zhang Chun, Lu Yanqun, Zhang Jihong   +5 more
doaj   +1 more source

Thalassemia and erythroid transcription factor KLF1 mutations associated with borderline hemoglobin A2 in the Thai population

Archives of Medical Science, 2020
Introduction Elevated hemoglobin (Hb) A 2 is an important diagnostic marker for β-thalassemia carriers. However, diagnosis of cases with borderline Hb A 2 may be problematic.
Hataichanok Srivorakun, Wachiraporn Thawinan, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Supan Fucharoen   +4 more
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Epigenetic Insights and Potential Modifiers as Therapeutic Targets in β–Thalassemia

Biomolecules, 2021
Thalassemia, an inherited quantitative globin disorder, consists of two types, α– and β–thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or even severe.
Nur Atikah Zakaria, Md Asiful Islam, Wan Zaidah Abdullah, Rosnah Bahar, Abdul Aziz Mohamed Yusoff, Ridhwan Abdul Wahab, Shaharum Shamsuddin, Muhammad Farid Johan   +7 more
doaj   +1 more source

Effect of Assorted Globin Haplotypes and α-Thalassemia on the Clinical Heterogeneity of Hb S-β-Thalassemia

, 2019
Hemoglobinopathies and thalassemias are the most commonly encountered monogenic disorders of blood in humans, posing a major genetic and public health problem round the globe.
Kiran R. Kharat (686460), Praveen K. Sahu (1846699), Preetinanda M. Dash (6021755), Ranjeet S. Mashon (6021761), Malay B. Mukherjee (6021764), Siris Patel (6021758)   +5 more
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