Results 41 to 50 of about 2,697,911 (252)
Protein C and Protein S Levels in β-Thalassemia Major Patients in Erbil, Kurdistan Region
Cellular and Molecular Biology, 2020 Oxygen is transported in the blood through red blood cells and a protein called hemoglobin. The protein consists of two alpha and two beta chains. The lack of any of these chains is caused by the malfunction of the genes that produce them, and can lead to a genetic disease called thalassemia.
Tareefa Kakakhan, Hadi +2 more
openaire +3 more sources
Pharmaceuticals, 2022 A significant amount of attention has recently been devoted to the mechanisms involved in hemoglobin (Hb) switching, as it has previously been established that the induction of fetal hemoglobin (HbF) production in significant amounts can reduce the ...
R. Bou-Fakhredin +4 more
semanticscholar +1 more source
Blood, 2022 Key Points • Adenine base editors efficiently correct the IVS1-110 (G>A) β-thalassemia–causing mutation.• Base editing efficiently corrects the β-thalassemic phenotype in vitro and in vivo.
G. Hardouin +10 more
semanticscholar +1 more source
, 2023 Introduction Splenomegaly and hypersplenism are common complications of thalassemia patients due to the excessive clearance of defective red blood cells from the spleen.
Shang H. (16810938) +9 more
core +1 more source
A Comparison of Intelligence Quotient in Children with and without β-Thalassemia Major
Galen Medical Journal, 2015 Background: Thalassemia is the most common hemoglobinopathy worldwide. Children with β-thalassemia major have several risk factors for cognitive problems. The aim of this study is to evaluate intelligence quotient in children with β-thalassemia major and healthy counterparts using Wechsler Intelligence Scale.
Samaneh Homayouni Meymandi +2 more
openaire +2 more sources
Blood, 2022 Transferrin receptor 1 (TFR1) performs a critical role in cellular iron uptake. Hepatocyte TFR1 is also proposed to influence systemic iron homeostasis by interacting with the hemochromatosis protein HFE to regulate hepcidin production.
Xia Xiao +7 more
semanticscholar +1 more source
Alpha-Hemoglobin Stabilizing Protein Gene Polymorphism (rs4499252 A/G) and its Association with Beta-Thalassemia Major in Iraqi Patients [PDF]
Archives of Razi Institute, 2022 Beta thalassemia (β-thalassemia) major is a genetic disorder of hemoglobin production that results in a diminished rate of synthesis of one or more of the globin chains causing variable degrees of anemia.
M Adnan Khalaf +3 more
doaj +1 more source
β-THALASSEMIA TRAIT MENGGUNAKAN ELEKTROFORESIS MIKROKAPILER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY, 2018 Thalassemia is a genetic disorder disease which spread in the different parts of the world, including Indonesia. The incidence of β-thalassemia trait in Indonesia is between 3−8%. The objective of this study is to know the incidence of β-thalassemia trait in studentswho performed medical check-up, which obtain by using capilary electrophoresis, to ...
Nuryanti Nuryanti +2 more
openaire +2 more sources
Journal of Clinical Investigation, 2021 Anemia in β-thalassemia is related to ineffective erythropoiesis and reduced red cell survival. Excess free heme and accumulation of unpaired α-globin chains impose substantial oxidative stress on β-thalassemic erythroblasts and erythrocytes, impacting ...
A. Matte +23 more
semanticscholar +1 more source
Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia
Anemia, 2022 Background. β-Thalassemia has a very wide clinical variation, depending on the severity of the patient’s condition. Individuals with β-thalassemia traits are usually asymptomatic; however, laboratory examination will show mild anemia with microcytic ...
Dian Puspita Sari +5 more
doaj +1 more source