Results 51 to 60 of about 2,697,911 (252)

The hypercoagulation state among major β-thalassemia patients at H. Adam Malik Hospital, Medan, Indonesia

Bali Medical Journal, 2019
Background: Thalassemia is the most common hereditary blood disorder in the world and Indonesia. Major β-thalassemia is classified as Transfusion-Dependent Thalassemia (TDT). Specific changes in the composition of red cell membrane lipids and hemosiderosis may lead to hypercoagulation.
Jane Tetraulina Silitonga, Adi Koesoema Aman, Bidasari Lubis   +2 more
openaire   +1 more source

Prevalence and molecular characterization of common thalassemia among people of reproductive age in the border area of Guangxi-Yunnan-Guizhou province in Southwestern China

Hematology, 2022
Objectives: Thalassemia, the most common global monogenetic disorder, is highly prevalent in southern China. Epidemiological and molecular characterization of thalassemia is important for designing appropriate prevention strategies in high-risk areas ...
GuiDan Xu, ChunFang Wang, JunLi Wang, Min Lin, ZhengYi Chang, JuHua Liang, XiaoHao Chen, ShiMao Zhong, XueJuan Nong, WuJun Wei, YiBin Deng   +10 more
doaj   +1 more source

Significance of borderline HbA2 levels in β thalassemia carrier screening

Scientific Reports, 2022
Increased HbA2 levels are the characteristic feature of β-thalassemia carriers. A subset of carriers however do not show HbA2 levels in the typical carrier range (≥ 4.0%) but show borderline HbA2 levels.
S. Colaco, R. Colah, A. Nadkarni
semanticscholar   +1 more source

Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia

, 2022
BACKGROUND: The frequency of the beta-thalassemia (β-thalassemia) gene in Indonesia ranges from 3 to 10%. However, in the East Java province, there is still limited information on the prevalence of β-thalassemia mutations in clinically diagnosed beta ...
Lesmana, Indra, Rahmawan, Prafa Alif, Indrasari, Yulia Nadar, Abdul Rahim, Nur Arzuar, Syafitri, Yuli, Rahim, Nur Arzuar Abdul, Moses, Emmanuel Jairaj, Yusoff, Narazah Mohd, Hernaningsih, Yetti, Andarsini, Mia Ratwita   +9 more
core   +1 more source

Molecular understanding of unusual HbE-β+-thalassemia with Hb phenotype similar to HbE heterozygote: simple and rapid differentiation using HbE levels

Annals of Medicine, 2023
Background Low HbF expression in HbE-β+-thalassemia may lead to misdiagnosis of HbE heterozygosity. We aimed to characterize the β- and α-globin genes and the modifying factors related to HbF expression in patients with an Hb phenotype similar to that of
Wittaya Jomoui, Surada Satthakarn, Sitthichai Panyasai   +2 more
doaj   +1 more source

MOESM1 of A validated cellular biobank for β-thalassemia

, 2016
Additional file 1: Table S1. List of the subjects (patients and healthy subjects) present in the Thal-Biobank.
Cosenza, Lucia, Breda, Laura, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Lampronti, Ilaria, Borgatti, Monica, Chiavilli, Francesco, Gamberini, Maria, Satta, Stefania, Manunza, Laura, Martis, Franca, Moi, Paolo, Rivella, Stefano, Gambari, Roberto, Bianchi, Nicoletta   +15 more
openaire   +1 more source

Survival and causes of death in 2,033 patients with non-transfusion-dependent β-thalassemia

Haematologica, 2021
Non-transfusion-dependent β-thalassemia (NTDT) is a broad term encompassing patients who do not require lifelong transfusion therapy for survival. NTDT patients commonly, but not exclusively, present to medical care later in childhood (commonly >2 years ...
K. Musallam, A. Vitrano, A. Meloni, S. Pollina, M. Karimi, A. El-Beshlawy, Mahmoud Hajipour, V. Di Marco, S. Ansari, A. Filosa, P. Ricchi, A. Ceci, S. Daar, E. Vlachaki, S. Singer, Z. Naserullah, A. Pepe, S. Scondotto, G. Dardanoni, F. Bonifazi, V. Sankaran, E. Vichinsky, A. Taher, A. Maggio   +23 more
semanticscholar   +1 more source

MOESM2 of A validated cellular biobank for β-thalassemia

, 2016
Additional file 2: Table S2. HbF and HbA2 production in ErPC cultures from 14 β-thalassemia patients after 4 and 8 days differentiation.
Cosenza, Lucia, Breda, Laura, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Lampronti, Ilaria, Borgatti, Monica, Chiavilli, Francesco, Gamberini, Maria, Satta, Stefania, Manunza, Laura, Martis, Franca, Moi, Paolo, Rivella, Stefano, Gambari, Roberto, Bianchi, Nicoletta   +15 more
openaire   +1 more source

Study of discriminant factor M/H ratio in screening for β thalassemia trait

IP Journal of Diagnostic Pathology and Oncology, 2020
Introduction: Beta Thalassemia syndrome is a group of hereditary disorders characterized by genetic deficiency in the synthesis of beta globin chains located on chromosome 11. A major diagnostic challenge is to differentiate between mild microcytic hypochromic anaemia due to BTT from other causes such as iron deficiency (IDA), sideroblastic anaemia etc.
openaire   +2 more sources

Changing patterns in the epidemiology of β‐thalassemia

European Journal of Haematology, 2020
β‐thalassemia major is an inherited hemoglobinopathy that requires lifelong red blood cell transfusions and iron chelation therapy to prevent complications due to iron overload.
A. Kattamis, G. Forni, Y. Aydinok, V. Viprakasit   +3 more
semanticscholar   +1 more source