Results 61 to 70 of about 920,848 (226)

Lymphocyte subsets in untreated thalassemia patients: differences by genotype and age

Frontiers in Immunology
BackgroundThe Lymphocyte subsets in treatment-naïve patients and their variations among different genetic subtypes and age groups remain poorly characterized.MethodsTo characterize the distribution of lymphocyte subsets in treatment-naïve thalassemia ...
Renbin Zhao, Renbin Zhao, Renbin Zhao, Xiangmei Yao, Xiangmei Yao, Xiangmei Yao, Shuai Feng, Shuai Feng, Shuai Feng, Peng Hu, Yunlian Zou, Yunlian Zou, Yunlian Zou, Zefeng Yang, Zefeng Yang, Zefeng Yang, Jinping Zhang, Jinping Zhang, Jinping Zhang, Xin Guan, Xin Guan, Xin Guan, Chaoran Zhang, Chaoran Zhang, Chaoran Zhang, Zhongyu Wang, Jie Zhang, Zengzheng Li, Zengzheng Li, Zengzheng Li, Yajie Wang, Yajie Wang, Yajie Wang   +32 more
doaj   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Relationship between Ferritin Levels with Calcium Levels in Patients Thalassemia β Major in Hospital in Jember

Journal of Agromedicine and Medical Sciences (AMS), 2023
Thalassemia β major is a hereditary disorder caused by mutations in the β-globin gene, which regulates the formation of one of the components that make up hemoglobin. This disorder results in the production of β-globin chains being reduced or not formed.
Fantya Cerebella Aslamy, Rini Riyanti, Cholis Abrori   +2 more
doaj   +1 more source

Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia

Blood Advances
Abstract Transfusion-dependent thalassemia (TDT) is a type of protein aggregation disease. Its clinical heterogeneity imposes challenges in effective management. Red blood cell (RBC) variables may be clinically relevant as mechanistic parts or tellers of TDT pathophysiology.
Konstantina Theocharaki, Alkmini T. Anastasiadi, Sophia Delicou, Vassilis L. Tzounakas, Ioanna Barla, Stella Rouvela, Evgenia Kazolia, Georgia Tzafa, George Mpekoulis, Theodore Gousdovas, Efthymia Pavlou, Ioannis V. Kostopoulos, Athanassios D. Velentzas, Nikolaos Simantiris, Aikaterini Xydaki, Niki Vassilaki, Ersi Voskaridou, Ioanna-Katerina Aggeli, Efrosyni Nomikou, Ourania Tsitsilonis, Efstathia Papageorgiou, Nikolaos Thomaidis, Evangelos Gikas, Marianna Politou, Veroniki Komninaka, Marianna H. Antonelou   +25 more
openaire   +3 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Deletional a-thalassemia 1 gene detection and hematological analysis in carrier with β-thalassemia

Journal of Associated Medical Sciences, 2012
There are high prevalence of β-thalassemia and α-thalassemia in the upper Northern Thailand. Thus, the interaction between β-thalassemia and α-thalassemia can be occurred.
Sitthichai Panyasai
doaj  

Sotatercept, a novel transforming growth factor β ligand trap, improves anemia in β-thalassemia: a phase II, open-label, dose-finding study

Haematologica, 2019
β-thalassemia, a hereditary blood disorder caused by defective synthesis of hemoglobin β globin chains, leads to ineffective erythropoiesis and chronic anemia that may require blood transfusions.
Maria Domenica Cappellini, John Porter, Raffaella Origa, Gian Luca Forni, Ersi Voskaridou, Frédéric Galactéros, Ali T. Taher, Jean-Benoît Arlet, Jean-Antoine Ribeil, Maciej Garbowski, Giovanna Graziadei, Chantal Brouzes, Michaela Semeraro, Abderrahmane Laadem, Dimana Miteva, Jun Zou, Victoria Sung, Tatiana Zinger, Kenneth M. Attie, Olivier Hermine   +19 more
doaj   +1 more source

Development and Validation of a Nomogram Based on Red Blood Cell and Reticulocyte Parameters for Differentiating Thalassemia Trait From Iron Deficiency Anemia

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia trait (TT) and iron deficiency anemia (IDA) are the primary causes of microcytic hypochromic anemia with overlapping hematological features, making their differential diagnosis challenging, so this study developed and validated a nomogram integrating red blood cell (RBC) count, mean corpuscular volume (MCV), reticulocyte percentage (RET ...
Yong Chen, Yazhen Mao, Jie Liu, Yice Lin, Dandan Chen   +4 more
wiley   +1 more source

Clinical and Laboratory Study of Sickle Cell/β-Thalassemia [PDF]

, 1986
We have studied 39 patients doubly heterozygous for sickle cell/β-thalassemia, 12 with sickle cell/βo- thalassemia and 27 with sickle cell/β+-thalassemia. Generally, sickle cell/βo-thalassemia is considered more severe than sickle cell/β+-thalassemia. In
Maeda, Koichi, Van Slyck, Ellis J., Hawley, Robert C.   +2 more
core   +1 more source

Diagnose Mutations Causes Î’-Thalassemia: Biomining Method Using an Optimal Neural Learning Algorithm

International Journal of Engineering and Technology, 2019
The problems in genome and proteome classification of mutations causing a thalassemia are synthesis, e.g. which thalassemia's database will choose? and then the technique that used in biomining to classify mutations causing thalassemia who can say is effective/optimal.
openaire   +1 more source