Results 71 to 80 of about 2,697,911 (252)

Thalassemia and erythroid transcription factor KLF1 mutations associated with borderline hemoglobin A2 in the Thai population

Archives of Medical Science, 2020
Introduction Elevated hemoglobin (Hb) A 2 is an important diagnostic marker for β-thalassemia carriers. However, diagnosis of cases with borderline Hb A 2 may be problematic.
Hataichanok Srivorakun, Wachiraporn Thawinan, Goonnapa Fucharoen, Kanokwan Sanchaisuriya, Supan Fucharoen   +4 more
doaj   +1 more source

Real-life experience with luspatercept in transfusion-dependent β-thalassemia

, 2023
β-Thalassemia is an autosomal recessive hemoglobinopathy characterized by the absence or reduction of β-globin chains synthesis [1]. Advancements in β-thalassemia therapy [2, 3] include emerging treatments like gene therapy [4, 5] and erythroid ...
Grande D., Longo M. C., Albano F., Roccotelli D., Vitucci A., Cicco G., Palma A., Musto P.   +7 more
core   +1 more source

Genotypic distribution of thalassemia in pregnant women in Nanning, Guangxi, and its impact on pregnancy outcomes

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To investigate the genotypic distribution of thalassemia in pregnant women in Nanning, Guangxi, and its impact on pregnancy outcomes.Methods·A retrospective cohort study was conducted among 3 649 pregnant women enrolled from January 2021 to ...
Li Jing, Liang Xuxia, Wu Hua, Zhang Chun, Lu Yanqun, Zhang Jihong   +5 more
doaj   +1 more source

The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

Frontiers in Genetics, 2022
Background: Thalassemia is a common inherited hematological disease with genetic disorders characterized by imbalanced synthesis of the globin chains.
Jingxian Ding, Zhaohui Huang, Xiaoliu Jiang, Qingge Li, Yali Cao, Yonghong Guo   +5 more
doaj   +1 more source

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Medical Science Monitor
In 2020, Emmanuelle Charpentier and Jennifer Doudna were awarded the Nobel Prize in Chemistry for their research on the endonuclease, clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated protein 9 (CRISPR-Cas9 ...
D. Parums
semanticscholar   +1 more source

Conditioning Regimens in Patients with β-Thalassemia Who Underwent Hematopoietic Stem Cell Transplantation: A Scoping Review

Journal of Clinical Medicine, 2022
The success of transplant procedures in patients with beta-thalassemia major (β-thalassemia) goes hand-in-hand with improvements in disease knowledge, better supportive care, discoveries in immunogenetics, increase in stem cell sources, and enhancement ...
O. Mulas, Brunella Mola, G. Caocci, G. La Nasa   +3 more
semanticscholar   +1 more source

Modified lentiviral globin gene therapy for pediatric β0/β0 transfusion-dependent β-thalassemia: A single-center, single-arm pilot trial.

Cell Stem Cell
β0/β0 thalassemia is the most severe type of transfusion-dependent β-thalassemia (TDT) and is still a challenge facing lentiviral gene therapy. Here, we report the interim analysis of a single-center, single-arm pilot trial (NCT05015920) evaluating the ...
Shi-Qi Li, Sikai Ling, Dawei Wang, Xiaoyuan Wang, Fangyuan Hao, Liufan Yin, Zhong-Tao Yuan, Lin Liu, Lin Zhang, Yu Li, Ying-Nian Chen, Le Luo, Ying Dai, Li-Hua Zhang, Lvzhe Chen, Dongjie Deng, Wei Tang, Su-Jiang Zhang, Sanbin Wang, Yu-Jia Cai   +19 more
semanticscholar   +1 more source

Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management

Biology, 2022
Simple Summary Atrial fibrillation in patients with β-thalassemia has a higher incidence compared to the general population. Its pathophysiology is peculiar and strictly related to anemia, iron overload, hemolysis, inflammation, atrial dilatation ...
M. Malagù, F. Marchini, Alessio Fiorio, P. Sirugo, Stefano Cló, E. Mari, M. Gamberini, C. Rapezzi, M. Bertini   +8 more
semanticscholar   +1 more source

The interactions between ineffective erythropoiesis and ferroptosis in β-thalassemia

Frontiers in Physiology
In Guangxi, Hainan, and Fujian Province in southern China, β-thalassemia is a frequent monogenic hereditary disorder that is primarily defined by hemolytic anemia brought on by inefficient erythropoiesis. It has been found that ineffective erythropoiesis
Siyang Lin, Yanping Zheng, Mei-Huan Chen, Liang-Pu Xu, Hai-Long Huang   +4 more
semanticscholar   +1 more source

Activation of STAT and SMAD Signaling Induces Hepcidin Re-Expression as a Therapeutic Target for β-Thalassemia Patients

Biomedicines, 2022
Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration. Hepcidin binds to the only known iron export protein, ferroportin (FPN), which regulates its expression.
H. Saad, A. A. Abd Rahman, Azly Sumanty Ab Ghani, W. Taib, Imilia Ismail, M. Johan, A. Al-Wajeeh, H. A. Al-Jamal   +7 more
semanticscholar   +1 more source