Results 91 to 100 of about 2,697,911 (252)

In silico analysis of substitution mutations in the β-globin gene in Turkish population of β-thalassemia

, 2023
Beta-thalassemia is a genetic blood disorder represented by anomalies in hemoglobin’s beta chain production. Most hemoglobin defects are a result of mutations of the structural β-globin gene.
Sima Alkilani (14586205), Tuba Sevimoglu (14586208)   +1 more
core   +1 more source

Lymphocyte subsets in untreated thalassemia patients: differences by genotype and age

Frontiers in Immunology
BackgroundThe Lymphocyte subsets in treatment-naïve patients and their variations among different genetic subtypes and age groups remain poorly characterized.MethodsTo characterize the distribution of lymphocyte subsets in treatment-naïve thalassemia ...
Renbin Zhao, Renbin Zhao, Renbin Zhao, Xiangmei Yao, Xiangmei Yao, Xiangmei Yao, Shuai Feng, Shuai Feng, Shuai Feng, Peng Hu, Yunlian Zou, Yunlian Zou, Yunlian Zou, Zefeng Yang, Zefeng Yang, Zefeng Yang, Jinping Zhang, Jinping Zhang, Jinping Zhang, Xin Guan, Xin Guan, Xin Guan, Chaoran Zhang, Chaoran Zhang, Chaoran Zhang, Zhongyu Wang, Jie Zhang, Zengzheng Li, Zengzheng Li, Zengzheng Li, Yajie Wang, Yajie Wang, Yajie Wang   +32 more
doaj   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source

Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia

Blood Advances
Abstract Transfusion-dependent thalassemia (TDT) is a type of protein aggregation disease. Its clinical heterogeneity imposes challenges in effective management. Red blood cell (RBC) variables may be clinically relevant as mechanistic parts or tellers of TDT pathophysiology.
Konstantina Theocharaki, Alkmini T. Anastasiadi, Sophia Delicou, Vassilis L. Tzounakas, Ioanna Barla, Stella Rouvela, Evgenia Kazolia, Georgia Tzafa, George Mpekoulis, Theodore Gousdovas, Efthymia Pavlou, Ioannis V. Kostopoulos, Athanassios D. Velentzas, Nikolaos Simantiris, Aikaterini Xydaki, Niki Vassilaki, Ersi Voskaridou, Ioanna-Katerina Aggeli, Efrosyni Nomikou, Ourania Tsitsilonis, Efstathia Papageorgiou, Nikolaos Thomaidis, Evangelos Gikas, Marianna Politou, Veroniki Komninaka, Marianna H. Antonelou   +25 more
openaire   +3 more sources

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Deletional a-thalassemia 1 gene detection and hematological analysis in carrier with β-thalassemia

Journal of Associated Medical Sciences, 2012
There are high prevalence of β-thalassemia and α-thalassemia in the upper Northern Thailand. Thus, the interaction between β-thalassemia and α-thalassemia can be occurred.
Sitthichai Panyasai
doaj  

Relationship between Ferritin Levels with Calcium Levels in Patients Thalassemia β Major in Hospital in Jember

Journal of Agromedicine and Medical Sciences (AMS), 2023
Thalassemia β major is a hereditary disorder caused by mutations in the β-globin gene, which regulates the formation of one of the components that make up hemoglobin. This disorder results in the production of β-globin chains being reduced or not formed.
Fantya Cerebella Aslamy, Rini Riyanti, Cholis Abrori   +2 more
doaj   +1 more source

Improving outcomes and quality of life for patients with transfusion-dependent β-thalassemia: recommendations for best clinical practice and the use of novel treatment strategies

Expert Review of Hematology, 2021
Introduction β-thalassemia is one of the most common inherited monogenic diseases. Many patients are dependent on a lifetime of red blood cell (RBC) transfusions and iron chelation therapy. Although treatments have a significant impact on quality of life
A. Taher, R. Bou-Fakhredin, A. Kattamis, V. Viprakasit, M. Cappellini   +4 more
semanticscholar   +1 more source

Application of Machine Learning Approaches in Electrophoresis—A Comprehensive Review

ELECTROPHORESIS, EarlyView.
This review paper highlights key research on the applications of machine learning tools in electrophoresis. ABSTRACT The electrophoretic technique is widely used to analyze and purify charged molecules based on their size, shape, and charge using an electric field for various applications, including DNA fingerprinting, genetic research, disease ...
Umaeer Al Hammad, Aminul Islam Khan, Prashanta Dutta   +2 more
wiley   +1 more source

Sotatercept, a novel transforming growth factor β ligand trap, improves anemia in β-thalassemia: a phase II, open-label, dose-finding study

Haematologica, 2019
β-thalassemia, a hereditary blood disorder caused by defective synthesis of hemoglobin β globin chains, leads to ineffective erythropoiesis and chronic anemia that may require blood transfusions.
Maria Domenica Cappellini, John Porter, Raffaella Origa, Gian Luca Forni, Ersi Voskaridou, Frédéric Galactéros, Ali T. Taher, Jean-Benoît Arlet, Jean-Antoine Ribeil, Maciej Garbowski, Giovanna Graziadei, Chantal Brouzes, Michaela Semeraro, Abderrahmane Laadem, Dimana Miteva, Jun Zou, Victoria Sung, Tatiana Zinger, Kenneth M. Attie, Olivier Hermine   +19 more
doaj   +1 more source