Results 131 to 140 of about 3,518,946 (289)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Koiran suoliston β-glukuronidaasiaktiivisuus : määrittäminen ja siihen vaikuttavat tekijät

, 2002
Suoliston normaaliflooran merkitystä ihmisten ja koirien terveyteen ja erilaisten sairaustilojen etiologiaan on tutkittu vähän. Hankaluutena on, että bakteerifloora on runsas ja sisältää niin paljon erilaisia mikrobeja, että yksittäisten mikrobien ...
Määttänen, Unna, Nyyssönen, Niina
core  

Crystal structure of (3R*,3aR*,4S*,7S*,7aR*)-4-(tert-butyldimethylsilyloxy)-4,7-epoxy-3-methoxy-7-methyloctahydro-1H-inden-1-one, C17H30O4Si

Zeitschrift für Kristallographie - New Crystal Structures, 2000
Tinant B., Trembleau L., Ghosez L.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An examination of VEGF, its receptors and the adherens junction component, β-catenin in the development of primary varicose veins [PDF]

, 2010
Vascular endothelial growth factor (VEGF-A) plays a central role in the maintenance of vascular reactivity and its aberrant control/function is implicated in the development of varicose veins (VVs).
Powell, G.L.
core  

ΝΟΥΣ, ΝΟΗΣΒΣ, ΝΟΕΒΝ and derivatives, in Plato's Philosophy

Revista Archai
The article shows that several studies on the meaning of νοῦς, νόησις, νοεῖν, and derivatives in pre-Platonic literature, especially in Homer, but also in some pre-Socratic thinkers, have concluded that these terms are never used in strictly abstract situations, but, on the contrary, always appear linked to emotions connected to concrete events.
openaire   +1 more source

ὥσπερ ἴχνεσι τοῖς ὀνόμασι. Plutarch’s Cratylus

Ploutarchos, 2023
The article traces the presence of Plato’s Cratylus" in the works of Plutarch, with a particular focus on its refunctionalization within the Plutarchian discursive context. Building on several scholarly contributions on this subject, the article highlights Plutarch’s exegetical sophistication, demonstrating his ability to selectively appropriate and ...
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Triumph of the ΠΑΝΤΟΠΟΡΟΣ? The image of the self‘invented and self inventing Δεινον in antigone’s first stasimon

Revista Filosófica de Coimbra, 2019
This paper focuses on Antigone’s first stasimon and tries to work out its meaning. The key question to be answered is: what image of man underlies the famous choral ode? This key question can be divided into several sub-questions:1) In what sense is man said to be δεινόν and indeed the most δεινόν thing of all?2) What is the connection ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source