Results 111 to 120 of about 3,518,946 (289)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Η θεατρική αγωγή στο προαιρετικό ολοήμερο σχολείο : εμπειρική διερεύνηση στα δημοτικά σχολεία της Κρήτης [PDF]
, 2011 Με την επίσημη εισαγωγή της Θεατρικής Παιδείας στο δημοτικό σχολείο εκδίδεται το πρώτο εγχειρίδιο-βοήθημα για το δάσκαλο, αρχίζει η πιλοτική εφαρμογή του προγράμματος “Μελίνα” και δημιουργείται η αρχή, πάνω στην οποία θα στηριχτεί ο εκπαιδευτικός για να ...
Ιωακειμίδης, Παντελής Β
core
Annals of MedicineFrom tumorigenesis to the establishment of local or metastatic high-grade tumours, an integral part of the cellular lifespan relies on various signalling pathways.
Aviv Philip Goncharov +5 more
doaj +1 more source
Revista ArchaiIn this paper, I aim to reject the thesis that ancient democracy, according to Aristotle, is defined by majority rule for its own benefit. I advocate for an alternative thesis, (which easily incorporates what is true in the rejected view), namely, that it is the concept of eleutheria, particularly as understood in Politics VI.2 and VI.9, that holds ...
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2012 The recent financial crisis and its effect on the deepening global economic recession have focused world attention on the protection of investors and more specifically on the “liability side” nature investors vis - a - vis investment firms when providing
Γρετσίτσα, Γεώργια Β.
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source