Results 101 to 110 of about 2,690,978 (249)

Crystal structure of (1R,2S,3R,5S)-2-(dimethylphenylsilyl)- 6-oxobicyclo[3.2.0]hept-3-yl acetate, C17H22O3Si

Zeitschrift für Kristallographie - New Crystal Structures, 1999
Tinant B., Declercq J.-P., Demaret C., Adam J.-M., Ghosez L.   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Crystal structure of (1S,2R,5R,6R)-2-methoxy-6-(16-nitrophenylethynyl)-1-azabicyclo[3.2.2]nonane, C17H20N2O3

Zeitschrift für Kristallographie - New Crystal Structures, 2000
Frackenpohl J., Roper S., Hoffmann Η. M. R., Wartchow R.   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Crystal structure of (3R*,3aR*,4S*,7S*,7aR*)-4-(tert-butyldimethylsilyloxy)-4,7-epoxy-3-methoxy-7-methyloctahydro-1H-inden-1-one, C17H30O4Si

Zeitschrift für Kristallographie - New Crystal Structures, 2000
Tinant B., Trembleau L., Ghosez L.
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ΝΟΥΣ, ΝΟΗΣΒΣ, ΝΟΕΒΝ and derivatives, in Plato's Philosophy

Revista Archai
The article shows that several studies on the meaning of νοῦς, νόησις, νοεῖν, and derivatives in pre-Platonic literature, especially in Homer, but also in some pre-Socratic thinkers, have concluded that these terms are never used in strictly abstract situations, but, on the contrary, always appear linked to emotions connected to concrete events.
openaire   +1 more source

ὥσπερ ἴχνεσι τοῖς ὀνόμασι. Plutarch’s Cratylus

Ploutarchos, 2023
The article traces the presence of Plato’s Cratylus" in the works of Plutarch, with a particular focus on its refunctionalization within the Plutarchian discursive context. Building on several scholarly contributions on this subject, the article highlights Plutarch’s exegetical sophistication, demonstrating his ability to selectively appropriate and ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Triumph of the ΠΑΝΤΟΠΟΡΟΣ? The image of the self‘invented and self inventing Δεινον in antigone’s first stasimon

Revista Filosófica de Coimbra, 2019
This paper focuses on Antigone’s first stasimon and tries to work out its meaning. The key question to be answered is: what image of man underlies the famous choral ode? This key question can be divided into several sub-questions:1) In what sense is man said to be δεινόν and indeed the most δεινόν thing of all?2) What is the connection ...
openaire   +1 more source