Results 171 to 180 of about 6,683,406 (342)

The phylogenomic landscape of extended-spectrum β-lactamase producing Citrobacter species isolated from surface water [PDF]

, 2023
Lee-Hendra Chenhaka, Deidre Alima Bregene van Wyk, Charlotte Mienie, Cornelius Carlos Bezuidenhout, Kgaugelo E. Lekota   +4 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

MicroRNA-1297 suppressed the Akt/GSK3 β signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model [PDF]

, 2021
Quan Wang, Jingcong Luo, Ruiqiang Sun, Jia Liu   +3 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Comparison of Effect of β-tricalciumphosphate and Deproteinized Bovine Bone in Sinus Lift Operation Comparative Histological and Histomorphometrical Study

Česká Stomatologie a Praktické Zubní Lékařství, 2006
The aim of this prospective study is to evaluate the quality of ß-tricalciumphosphate (Cerasorb, Curasan Pharma) and deproteinized bovine bone (Bio-Oss, Geistlich) used as augmentation materials for the sinus lift operation.Histomorphometry was carried ...
A. Šimůnek, A. Kohout, D. Kopecká
doaj  

In Situ Generated Novel 1H MRI Reporter for β-Galactosidase Activity Detection and Visualization in Living Tumor Cells [PDF]

, 2021
Shuo Gao, Zhao Lei, Zhiqiang Fan, Vikram D. Kodibagkar, Li Liu, Hanqin Wang, Hong Xu, TU Ming-li, Bifu Hu, Chuanbin Cao, Zhenjian Zhang, Jianxin Yu   +11 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Resorption of Augmenting Materials Used in Sinus Lift Operation

Česká Stomatologie a Praktické Zubní Lékařství, 2006
In certain cases conditions in oral cavity for introducing dental implants should be prepared before the operation. In lateral section of upper jaw the augmenting sinus lift procedure is almost an indispensable part of implantological therapy. The aim of
T. Brázda, A. Šimůnek, D. Kopecká, R. V. Somanathan, J. Bukač   +4 more
doaj  

Human Peripheral CD4+ Vδ1+ γδT Cells Can Develop into αβT Cells [PDF]

Frontiers in Immunology, 2014
Hendrik Ziegler, Christian Welker, Marco Sterk, Jan Haarer, Hans-Georg Rammensee, Rupert Handgretinger, Karin Schilbach   +6 more
openaire   +1 more source