Results 131 to 140 of about 1,305,371 (201)

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies

European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.
COPD is a heterogeneous disease driven by overlapping neutrophilic and eosinophilic inflammatory pathways. This review highlights the shift from symptom‐based treatment toward phenotype‐ and biomarker‐directed care. Blood eosinophils, FeNO, and IgE predict corticosteroid responsiveness and identify candidates for biologic therapy.
Sasha Raman, Sreya Rahman, Francesca Polverino, Muhammad Adrish   +3 more
wiley   +1 more source

Topical administration of adrenergic receptor pharmaceutics and nerve growth factor

, 2010
Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor ...
Jena J Steinle
core  

Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β‐Adrenoceptor Stimulation

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Annexin A4 (A4) inhibits adenylyl cyclase 5 and may protect the heart during chronic β‐adrenergic stress. After 7 days of isoprenaline, A4‐deficient mice showed greater cardiomyocyte hypertrophy, prolonged action potentials, reduced Ito, preserved ICaL with altered activation, increased NCX1, and enhanced acute cAMP responsiveness compared with wild ...
Florentina Pluteanu, Alexander Heinick, Manuel Domnik‐Lehnert, Frank U. Müller, Christina Hermes   +4 more
wiley   +1 more source

CRISPR-CasRx-mediated disruption of Aqp1/Adrb2/Rock1/Rock2 genes reduces intraocular pressure and retinal ganglion cell damage in mice

Nature Communications
Glaucoma affects approximately 80 million individuals worldwide, a condition for which current treatment options are inadequate. The primary risk factor for glaucoma is elevated intraocular pressure.
Mingyu Yao, Zhenhai Zeng, Siheng Li, Zhilin Zou, Zhongxing Chen, Xinyi Chen, Qingyi Gao, Guoli Zhao, Aodong Chen, Zheng Li, Yiran Wang, Rui Ning, Colm McAlinden, Xingtao Zhou, Jinhai Huang   +14 more
doaj   +1 more source

Orthodontic Root Resorption in Spontaneously Hypertensive Rats: Modulation by β2-Adrenergic Receptor Blockade. [PDF]

J Clin Med
Yoshida T, Sato T, Takahashi M, Ichikawa S, Tabuchi M, Miyazawa K.   +5 more
europepmc   +1 more source

Beta-adrenergic receptor regulation and airway inflammation

, 2005
There is ongoing concern that regular use of β2-agonists without additional use of inhaled steroids may contribute to an adverse outcome of asthma, which may in part be due to desensitization of the β2-adrenergic receptor (Chapter7 ). Therefore, there is
Oostendorp, Jaap
core   +1 more source

Biased signaling of β2-adrenergic receptor in physiological and pathological states. [PDF]

Cell Mol Biol Lett
Xu Y, Kawuribi V, Adu-Amankwaah J, Gong Z, Li X, Lei Y, Wang Z, Sakava PB, Zhao F, Pan X, Li C, Sun H, Fu L.   +12 more
europepmc   +1 more source

β2-adrenergic receptor stimulation drives differentiation of human adipose-derived mesenchymal stem cells into beige adipocytes. [PDF]

Adipocyte
Maekawa K, Yokoyama F, Tsutsumi R, Tateishi A, Maeda A, Tateishi N.   +5 more
europepmc   +1 more source

Stress‑induced catecholamines attenuate sorafenib efficacy by inhibiting ferroptosis in β2‑adrenergic receptor positive renal cell carcinoma. [PDF]

Int J Oncol
Ushijima M, Naito S, Ito H, Narisawa T, Ichiyanagi O, Kanno H, Fukuhara H, Takai Y, Yagi M, Yamagishi A, Nishida H, Obara Y, Tsuchiya N.   +12 more
europepmc   +1 more source

Salbutamol and Formoterol Attenuate Okadaic Acid-Induced Cytotoxicity in Undifferentiated PC-12 Cells: Evidence for a β2-Adrenergic Receptor-Independent Protective Component. [PDF]

Curr Issues Mol Biol
Kotsoni A, Ioannou E, Barmparousi E, Zacharia LC.   +3 more
europepmc   +1 more source