Results 31 to 40 of about 22,283 (171)

Beta 2-adrenergic pathway combats Alzheimer’s disease: Restoring cognition and synaptic integrity

Neural Regeneration Research
Alzheimer’s disease is typified by amyloid-beta oligomer-mediated synaptic disruption, neuroinflammation, and mitochondrial loss of function, culminating in cognitive decline.
Shaomin Li, Shan-Xue Jin
doaj   +1 more source

Additional file 5: of β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study

, 2015
BSS distribution stratified by copy number of combined haplotype TTGAC and separated by race. The scatter plots and the box-and-whisker plots of BSS across 0, 1, and 2 copies of combined haplotype TTGAC for both Caucasian and African American infants.
Pingsheng Wu, Larkin, Emma, Reiss, Sara, Carroll, Kecia, Summar, Marshall, Minton, Patricia, Woodward, Kimberly, Zhouwen Liu, Islam, Jessica, Hartert, Tina, Moore, Paul   +10 more
openaire   +1 more source

PO-17 ROLE OF NITRIC OXIDE IN β2-ADRENERGIC MEDIATED VASODILATION IN POSTMENOPAUSAL WOMEN

Artery Research, 2016
Objectives: Postmenopausal (PM) women have a blunted β2-adrenergic receptor-mediated responsiveness when compared to young premenopausal women in part due to a reduction in the relative contribution of nitric oxide (NO) to β2-adrenergic mediated ...
Sushant M. Ranadive, Roneé E. Harvey, Jacqueline K. Limberg, Timothy B. Curry, Wayne T. Nicholson, Michael J. Joyner   +5 more
doaj   +1 more source

Synthesis, Docking Study and β-Adrenoceptor Activity of Some New Oxime Ether Derivatives

Molecules, 2014
A new series of oxime ethers 4a–z was designed and synthesized to test the blocking activity against β1 and β2-adrenergic receptors. Docking of these ether derivatives into the active site of the identified 3D structures of β1 and β2-adrenergic receptors
Hazem A. Ghabbour, Eman R. El-Bendary, Mahmoud B. El-Ashmawy, Mohamed M. El-Kerdawy   +3 more
doaj   +1 more source

Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro.

PLoS ONE, 2014
Vagal nerve efferent activation has been shown to ameliorate the course of many inflammatory disease states. This neuro-modulatory effect has been suggested to rest on acetylcholine receptor (AChR) activation on tissue macrophages or dendritic cells (DCs)
Laurens E Nijhuis, Brenda J Olivier, Shobit Dhawan, Francisca W Hilbers, Louis Boon, Monika C Wolkers, Janneke N Samsom, Wouter J de Jonge   +7 more
doaj   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

Advanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà, Giulia Cazzador, Roberta Fabbri, Matteo Calosi, Alessandro Silvestri, Andrea Candini, Fabiola Liscio, Franco Corticelli, Aikaterini Konstantoulaki, Andrea D'Iorio, Marco Caprini, Vincenzo Palermo, Monica Bertoldo, Valentina Benfenati, Chiara Zanardi, Emanuele Treossi   +15 more
wiley   +1 more source

β2-adrenergic receptor regulates ER-mitochondria contacts

Scientific Reports, 2021
Interactions between the endoplasmic reticulum (ER) and mitochondria (Mito) are crucial for many cellular functions, and their interaction levels change dynamically depending on the cellular environment. Little is known about how the interactions between
Youngshin Lim, Il-Taeg Cho, Helmut G. Rennke, Ginam Cho   +3 more
doaj   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells

Nature Communications, 2022
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
Jaroslawna Meister, Derek B. J. Bone, Jonas R. Knudsen, Luiz F. Barella, Thomas J. Velenosi, Dmitry Akhmedov, Regina J. Lee, Amanda H. Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E. Jensen, Erik A. Richter, Jürgen Wess   +17 more
doaj   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source