Results 111 to 120 of about 22,609,963 (202)

Avidity of anti-β2-glycoprotein i antibodies in patients with antiphospholipid syndrome

, 2012
Antibodies against β2-glycoprotein I (anti-β2GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present
Swadzba, J., Gallova, Z. Ulcova, S. Cucnik, T. Kveder, Tervaert, J. W. Cohen, B. Bozic, Z. Ulcova Gallova, L. Stojanovich, J. Musial, Bozic, B., B. Rozman, ALESSANDRI, cristiano, Alessandri, C., VALESINI, Guido, J. Swadzba, Musial, J., A. Artenjak, Avcin, T., Iwaniec, T., Artenjak, A., J. w. Cohen Tervaert, Valesini, G., Cucnik, S., T. Iwaniec, T. Avcin, Kveder, T., Rozman, B., Stojanovich, L.   +27 more
core   +1 more source

Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis. [PDF]

, 2014
IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with the pathogenesis of APS, an autoimmune disease defined by thrombosis and pregnancy morbidity. To date, however, no study has demonstrated direct pathogenicity of IgG
Romay-Penabad, Z, Driscoll, Paul C, Marín, AC, Isenberg, DA, Isenberg, David A, Giles, I, Ioannou, Yiannis, Pericleous, Charis, Ruiz-Limon, Patricia, Garza-Garcia, A, Ruiz-Limón, P, Rahman, Anisur, Giles, Ian, Marin, Ana Carrera, Murfitt, Lucy, Latchman, David S, Rahman, A, Garza-Garcia, Acely, Ioannou, Y, Pericleous, C, Pierangeli, SS, Murfitt, L, Latchman, DS, Driscoll, PC, Pierangeli, Silvia S, Romay-Penabad, Zurina   +25 more
core   +1 more source

Male genital lichen sclerosus

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas, Rory Barry, Richard E. Watchorn, Christopher B. Bunker   +3 more
wiley   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Thrombembolic events in patients with non-hodgkin's lymphoma And anticardiolipin antibodies

Hematology Reports, 2020
Patients with non-Hodgkin's lymphoma (NHL) have an increased risk of thromboembolic events. It is important to identify NHL patients at increased risk of developing thromboembolic complications in order to apply prophylactic treatment.
S. Buruiana, M. Robu, V. Tomacinschii, M. Mazur   +3 more
doaj  

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Inter-laboratory Variability of Anti-β2-glycoprotein I Measurement

, 2002
SummaryInter-laboratory variability of anti-β2-glycoprotein I antibody measurements (IgG and IgM) was investigated in the frame of the European Forum on Antiphospholipid Antibodies and its Standardization Group.
Guido Reber, Tanja Kveder, Philippe de Moerloose, Angela Tincani, Josiane Arvieux, Inger Schousboe, Marielle Sanmarco, Marie-Claire Boffa   +7 more
core   +1 more source

The ABCs of antiphospholipid syndrome

The Turkish Journal of Gastroenterology, 2023
Antiphospholipid syndrome (APS) is a thromboinflammatory syndrome characterized by thrombotic, microvascular, obstetric, or non-thrombotic events in the setting of persistent antiphospholipid antibodies (aPL), namely anticardiolipin antibody (aCL), anti-
Ayşe Bahar Keleşoğlu Dinçer, Doruk Erkan   +1 more
doaj  

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source