Results 61 to 70 of about 3,155 (130)

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Angeliki S. Foscolos, Alexandros Pappas, Christos N. Petroulias, Anna Kapella, Georgia M. Prifti, Grigoris Zoidis, Minas Papadopoulos, Anastasia Mpakali, Aristeidis Chiotellis   +8 more
wiley   +1 more source

Protecting Against Postsurgery Oral Cancer Recurrence with an Implantable Hydrogel Vaccine for In Situ Photoimmunotherapy

Advanced Science
Oral squamous cell carcinoma (OSCC) often recurs aggressively and metastasizes despite surgery and adjuvant therapy, driven by postoperative residual cancer cells near the primary tumor site. An implantable in situ vaccine hydrogel was designed to target
Lan Chen, Qiqi Yin, Handan Zhang, Jie Zhang, Guizhu Yang, Lin Weng, Tao Liu, Chenghui Xu, Pengxin Xue, Jinchao Zhao, Han Zhang, Yanli Yao, Xin Chen, Shuyang Sun   +13 more
doaj   +1 more source

Normal reference ranges for urinary δ-aminolevulinic acid and porphobilinogen levels. [PDF]

JIMD Rep, 2021
Agarwal S, Habtemarium B, Xu Y, Simon AR, Kim JB, Robbie GJ.   +5 more
europepmc   +1 more source

A Non-functional γ-Aminobutyric Acid Shunt Pathway in Cyanobacterium Synechocystis sp. PCC 6803 Enhances δ-Aminolevulinic Acid Accumulation under Modified Nutrient Conditions. [PDF]

Int J Mol Sci, 2023
Kanwal S, De-Eknamkul W.
europepmc   +1 more source

Study on production of δ-aminolevulinic acid by fermentation of complex yeast

Siliao yanjiu
The research aims to improve the production of δ-aminolevulinic acid (δ-ALA) in yeast culture by compounding strains and optimizing cultivation conditions.
LIN Ziying, REN Wenbin, XIN Xuan, YANG Xiaohui, WANG Wei   +4 more
doaj  

Comparative study of oxidative stress in cancer patients occupationally exposed to the mixture of pesticides

Discover Oncology
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. Reviews indicated a positive relationship between exposure to pesticides and the development of cancers.
Anupama Ojha, Shashank Shekhar, Poonam Gupta, Sonali Jaiswal, Sarad Kumar Mishra   +4 more
doaj   +1 more source

Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan. [PDF]

J Occup Health, 2021
Ono A, Horiguchi H.
europepmc   +1 more source

Effect of Ozone Micro-Nano-Bubbles Treatment on “Green” and the Mechanism in Soybean Sprout

Shipin gongye ke-ji
In order to explore the effect of ozone micro-nano-bubbles (Ozone MNBs) on “green” and the regulative mechanism in soybean sprout, this study took soybean sprout as the experimental material, treated with 4 mg/L Ozone MNBs and stored in white LED ...
Hongdou GAO, Junyan SHI, Haitao LIU, Jinhua ZUO, Shuzhi YUAN, Xiaozhen YUE, Qing WANG   +6 more
doaj   +1 more source

A CASE OF FAMILIAL PORFIRIA

Hematology, Transfusion and Cell Therapy
Introduction: Porphyria is a group of metabolic diseases caused by hereditary defects in the enzymatic system of heme biosynthesis. We present three cases of familial porphyria in two sisters (50 and 45-years-old) and a brother (39-years-old).
Laman Hamidova, Oktay Abdullayev, Zari Balaşova, Farid Mammadov   +3 more
doaj   +1 more source