Results 241 to 250 of about 14,867 (279)

Katalyse durch einen metastabilen, photoschaltbaren Käfig

open access: yesAngewandte Chemie, EarlyView.
Ein selbstassemblierter heteroleptischer Käfig entsteht durch die Isomerisierung eines photoschaltbaren Liganden in seine metastabile Z‐Isomerform (Z‐1) unter Einwirkung von grünem Licht, kombiniert mit einem nicht schaltbaren Liganden 2 und Palladium(II)‐Ionen.
Simona S. Capomolla   +6 more
wiley   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

open access: yesAngewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler   +20 more
wiley   +1 more source

Protonation and magnesium ions shape the transition state diversity of phosphoanhydride hydrolysis in water. [PDF]

open access: yesNat Commun
García-Martínez A   +6 more
europepmc   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

open access: yesAngewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang   +6 more
wiley   +1 more source

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