Results 71 to 80 of about 1,574,238 (214)

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn

Molecular Pain, 2010
Background There is anatomical and behavioural evidence that μ- and δ-opioid receptors modulate distinct nociceptive modalities within the superficial dorsal horn.
Vaughan Christopher W, Jeong Hyo-Jin, Wrigley Paul J   +2 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

[C]Carfentanil Binds Preferentially to μ-Opioid Receptor Subtype 1 Compared to Subtype 2

Molecular Imaging, 2015
The positron emission tomography (PET) ligand [ 11 C]carfentanil is a selective agonist for μ-opioid receptors and has been used for studying μ-opioid receptors in the human brain.
Olof Eriksson, Gunnar Antoni
doaj   +1 more source

Sodium Translocation through the μ-Opioid Receptor

, 2018
This public project contains data used in the analysis for the "Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis" PLOS Comp. Biol.
Xiaohu Hu, Yibo Wang, Marta Filizola, Davide Provasi   +3 more
core   +1 more source

Opioid Prescribing Changes in Advanced Cancer Before and After Withdrawal of Hydromorphone Slow‐Release Tablets

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Hydromorphone slow‐release tablet withdrawal from the Australian market altered opioid prescribing patterns in advanced cancer pain. Methadone use increased by nearly 50% and median doses doubled. There may be a need to tailor clinician training on safe and effective use of methadone and other opioids as appropriate. ABSTRACT Aim Ongoing disruptions to
Aaron K. Wong, Helen McManus, Sara Vogrin, Youseph Dib, Monnette Samo, Jonathan La, Brian Le, Jennifer Philip   +7 more
wiley   +1 more source

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Frontiers in Immunology, 2020
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang, Meirong Yang, Chunhua Chen, Liu Liu, Xinchuan Wei, Si Zeng   +5 more
doaj   +1 more source

Agonists at the delta-opioid receptor modify the binding of mu-receptor agonists to the mu-delta receptor hetero-oligomer

, 2010
BACKGROUND AND PURPOSE: μ- and δ-opioid receptors form heteromeric complexes with unique ligand binding and G protein-coupling profiles linked to G protein α z-subunit (Gα(z) ) activation. However, the mechanism of action of agonists and their regulation
GEORGE S. R., SR George, T Fan, NGUYEN T, BALBONI, GIANFRANCO, KABLI N, T Nguyen, O'DOWD B. F, A Hasbi, MARTIN N, N Kabli, N Martin, G Balboni, FAN T, HASBI A, BF O'Dowd   +15 more
core   +1 more source

Canine desexing attitudes and practices of Australian veterinarians: A cross‐sectional survey

Australian Veterinary Journal, EarlyView.
Canine desexing is one of the most common small animal surgical procedures in Australia, yet little is known about current practices. This study characterised attitudes, practitioner recommendations and surgical practices for routine canine desexing among Australian veterinarians using an online cross‐sectional survey (n = 107). Respondent demographics
S. Impey, M. Blevins, G. Chung, A. Goh, P. Rak   +4 more
wiley   +1 more source

Pharmacokinetics of tramadol and O‐desmethyltramadol in healthy dogs after a single oral dose of 2 mg/kg

Australian Veterinary Journal, EarlyView.
Tramadol exposure after low oral doses is variable in dogs, and the estimation of the terminal phase can be difficult when late concentrations plateau or rebound. This study characterized tramadol and O‐desmethyltramadol (M1) after a single oral dose of 2 mg/kg in 10 healthy female mixed‐breed dogs.
YDB Passos, NS Fernandes, KN Arcoverde, AN Mouta, R dos Anjos Honorato, G Araujo‐Silva, VV de Paula   +6 more
wiley   +1 more source