A portable system for economical nucleic acid amplification testing
Introduction: Regular and rapid large-scale screening for pathogens is crucial for controlling pandemics like Coronavirus Disease 2019 (COVID-19). In this study, we present the development of a digital point-of-care testing (POCT) system utilizing ...
Hui Dong +10 more
doaj +1 more source
CRISPR‐Enabled Point‐of‐Care Diagnostics for Early Cancer Detection
This review summarizes recent advances in CRISPR‐enabled point‐of‐care diagnostics for early cancer detection, covering Cas‐based recognition mechanisms, portable engineering platforms, and biomarker applications. It further highlights current challenges and future opportunities for translating sensitive, affordable, and accessible CRISPR diagnostics ...
Yuwei Pan +3 more
wiley +1 more source
Three-Dimensional Paper-Based Microfluidic Analytical Devices Integrated with a Plasma Separation Membrane for the Detection of Biomarkers in Whole Blood [PDF]
Paper-based microfluidic analytical devices (μPADs) have recently attracted attention as a point-of-care test kit because of their low cost and nonrequirement for external forces.
Soo-Kyung Kim (1632286) +5 more
core +1 more source
A CRISPR/Cas12a‐powered dendritic DNA nanostructure is assembled to create confined enzymatic microdomains, enabling ultrasensitive detection. Integrated into a paper‐based origami biosensor, it allows equipment‐free on‐site quantification of acidogenic pathogens for the early diagnosis of dental caries.
Yuan Zhang +4 more
wiley +1 more source
Wearable biofluids colorimetric biosensors
Wearable and flexible colorimetric sensors enable real‐time, non‐invasive detection through visible color changes. Advances in materials and device engineering have driven their development; however, challenges remain in sensitivity, selectivity, and scalable manufacturing.
Zhaoyuan Lyu +8 more
wiley +1 more source
Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang +7 more
wiley +1 more source
Flexible, Integrated‐Porous Microneedle Sensor for Biofluid Sampling and On‐Site Biomarker Detection
A paper‐integrated porous PGA microneedle array patch capable of both high strength and absorption capacity is proposed. With an image‐processing system, an optimized colorimetric sensor achieves a low limit of detection of 0.09 mm in cholesterol.
Haitao Deng +3 more
wiley +1 more source
Smart REASSURED Sensors via Machine‐Augmented Printable On‐Paper Arrays
This perspective highlights the emerging role of pattern‐recognition, printable on‐paper sensor arrays for intelligent PoC diagnostics. It discusses how paper's inherent limitations can be overcome through surface modification and scalable printing, and how machine‐learning analysis of cross‐reactive arrays enables multiplexed, low‐cost, and REASSURED ...
Naimeh Naseri, Saba Ranjbar
wiley +1 more source
Automated Immunoassay Performed on a 3D Microfluidic Paper-Based Device for Malaria Detection by Ambient Mass Spectrometry [PDF]
Microfluidic paper-based analytical devices (μPADs) are emerging as a prominent platform for disease detection, specifically in developing countries.
Sierra Jackson +5 more
core +1 more source
Nanozymes Integrated Biochips Toward Smart Detection System
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen +10 more
wiley +1 more source

