Results 141 to 150 of about 554,293 (337)

Enhancing antitumour response to proteasome inhibitors with inhibitors of insulin‐degrading enzyme, a new molecular vulnerability in multiple myeloma

open access: yesBritish Journal of Pharmacology, EarlyView.
Inhibitors of insulin‐degrading enzyme boost PI cytotoxicity through an increased sensitivity of proteasome to PI inhibitors, induction of ISR, DNA damage and Myc down‐regulation. They overcome PI resistance in vitro and induce tumour regression in vivo.
Laetitia Lesire   +28 more
wiley   +1 more source

Using miniaturized laboratory equipment and DNA barcoding to improve conservation genetics training and identify illegally traded species

open access: yesConservation Biology, EarlyView.
Abstract Illegal wildlife trade (IWT) is one of the largest global illegal activities, and it negatively affects biodiversity and sustainable development worldwide. DNA barcoding coupled with high‐throughput sequencing (i.e., metabarcoding) is useful in identifying taxa affected by IWT and has been used routinely for decades.
Maria Joana Ferreira da Silva   +9 more
wiley   +1 more source

A Comprehensive Approach to Post-Conflict Reconstruction: German Experience in Afghanistan

open access: yesVestnik RUDN. International Relations, 2016
As a part of a larger research project on complex linkages between security and development implemented by the Center for Security and Development Studies at the Lomonosov Moscow State University, this paper examines the complex dilemmas of pursuing ...
Philip Olegovich Trunov
doaj  

An Angler‐Friendly AI Pipeline for Self‐Reporting and Automatic Catch Analysis in Recreational Fisheries

open access: yesFish and Fisheries, EarlyView.
ABSTRACT Monitoring recreational fisheries is difficult: anglers are widely dispersed, gear and practices vary, and many species are involved, which leads to fragmented and scarce data. To address these issues, we developed an Artificial Intelligence (AI) pipeline that turns angler‐reported photos into standardised records of catch composition and ...
Marco Signaroli   +9 more
wiley   +1 more source

Main Forms of Inter-State Cooperation in the Field of Migration

open access: yesRUDN Journal of Law, 2016
Unity of all movements of the population covered by the concept of migration as a subject of international legal regulation, in terms of risks and the potential for States, societies and individuals objectively pushes States to a comprehensive approach ...
Ekaterina V Kiseleva
doaj  

СТАНОВЛЕНИЕ И РАЗВИТИЕ ПСИХОНЕЙРОЭНДОКРИНОЛОГИИ В МОСКОВСКОМ НАУЧНО-ИССЛЕДОВАТЕЛЬСКОМ ИНСТИТУТЕ ПСИХИАТРИИ

open access: green, 2020
Людмила Николаевна Горобец   +3 more
openalex   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

open access: yesThe FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo   +16 more
wiley   +1 more source

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