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Clinical Pharmacology in Health Care, Teaching and Research

Качественная клиническая практика, 2020
Published jointly by CIOMS, IUPHAR and WHO in 2012 under the title "Clinical Pharmacology in Health Care, Teaching and Research".Russian Association of Clinical Pharmacologists is gratefully acknowledged for its generous support to make this publication ...
Article Editorial
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Biosimilar of biphasic human insulin: results of a double-blind, randomized, comparative, cross-sectional clinical study of pharmacokinetics

Фармакокинетика и Фармакодинамика, 2019
Justification. The prevalence of type 2 diabetes is extremely high, and the number of such patients is constantly increasing. In 30-40% of patients, only insulin therapy can achieve compensation for the disease.
Tatyana Karonova, Alexander Mayorov, Igor Makarenko, Ekaterina Koksharova, Olga Ilyinichna Avdeeva, Alena Andreeva, Roman Dray   +6 more
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On the question of the antiproliferative coating of coronary stents

Патология кровообращения и кардиохирургия, 2018
The article looks at the issue of antiproliferative coatings of drug eluting coronary stents from a perspective of their pharmacological properties. Antiproliferative drugs from the “limus” group used in coronary stents do not have decisive advantages ...
Alexander M. Digay
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Results of a double-blind, randomized, comparative, cross-sectional study of the pharmacokinetics and pharmacodynamics of genetically engineered human insulin preparations

Фармакокинетика и Фармакодинамика, 2019
Justification. On average, about 12 % of all global healthcare spending on diabetes. One of the first domestic human insulin preparations was Rinsulin® R, the biosimilar (bioanalog) of Humulin® Regular.
Alexander Mayorov, Olga Avdeeva, Ekaterina Koksharova, Tatyana Belikova, Ekaterina Mishina, Roman Dray   +5 more
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Antarite - synergistic combination of «magaldrat + simethicone» with gastroprotective properties

Фармакокинетика и Фармакодинамика, 2018
Resume. TThe preparation "Antarite” is a combination of magaldrate (antacid of a new generation) with simethicone (antifoam component to reduce flatulence).
I. Yu. Torshin, O. A. Gromova, N. A. Kuricina   +2 more
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Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice

Фармакокинетика и Фармакодинамика, 2023
Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose
L. P. Kovalenko, R. V. Zhurikov, P. Yu. Povarnina, A. V. Tarasiuk   +3 more
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Study of the antiarrhythmic activity of linear alkoxyphenylazalkanes in the model of reperfusion arrythmias in rats

Фармакокинетика и Фармакодинамика, 2023
The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model of reperfusion arrhythmia in rats.
V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. А. Kryzhanovskii, T. Yu. Vorobieva, V. E. Biryukova, G. V. Mokrov   +7 more
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COMPARISON OF PHARMACOKINETICS AND PHARMACODYNAMICS OF THE ORIGINAL AND GENERIC ENALAPRIL IN THE ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the pharmacokinetic, pharmacodynamic and pharmacoeconomic parameters of the original and generic enalaprils in the treatment of the elderly patients with hypertension (HT). Material and Methods.
O. P. Bobrova, M. M. Petrova
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The pilot study of the basic pharmacokinetic properties of pyrrolylcarnosine — the new pyrrolic derivative of dipeptide carnosine

Фармакокинетика и Фармакодинамика, 2023
The experimental study of the pharmacokinetic characteristics of a new pyrrole derivative of carnosine, pyrrolylcarnosine, was carried out. Based on the results of the experiment, the basic pharmacokinetic parameters of the drug are expected. The tissues
D. A. Abaimov, Anastasiya V. Khutorova, A. K. Sariev, O. I. Kulikova, M. A. Belousova, S. L. Stvolinsky, V. A. Migulin, T. N. Fedorova   +7 more
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Study of the effect of food on the bioavailability, safety and tolerability of Aterixen^® 100 mg tablet in healthy volunteers

Фармакокинетика и Фармакодинамика, 2023
The aim. The primary objective of the study was to evaluate the effect of food on the bioavailability of Aterixen® 100 mg tablet after single oral dose under fasting or fed conditions.
V. B. Vasilyuk, Yu. A. Dzhurko, A. A. Globenko, L. N. Schitov, V. N. Shabrov, M. A. Pasko, O. V. Kovchan, A. V. Kapashin, A. I. Bashkatova   +8 more
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